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Neighbourhood disadvantage impacts on pulmonary function in patients with sarcoidosis
BACKGROUND: This multicentre, international, prospective cohort study evaluated whether patients with pulmonary sarcoidosis living in neighbourhoods with greater material and social disadvantage experience worse clinical outcomes. METHODS: The area deprivation index and the Canadian Index of Multipl...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Respiratory Society
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589334/ https://www.ncbi.nlm.nih.gov/pubmed/36299359 http://dx.doi.org/10.1183/23120541.00357-2022 |
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author | Goobie, Gillian C. Ryerson, Christopher J. Johannson, Kerri A. Keil, Spencer Schikowski, Erin Khalil, Nasreen Marcoux, Veronica Assayag, Deborah Manganas, Hélène Fisher, Jolene H. Kolb, Martin R.J. Chen, Xiaoping Gibson, Kevin F. Kass, Daniel J. Zhang, Yingze Lindell, Kathleen O. Nouraie, S. Mehdi |
author_facet | Goobie, Gillian C. Ryerson, Christopher J. Johannson, Kerri A. Keil, Spencer Schikowski, Erin Khalil, Nasreen Marcoux, Veronica Assayag, Deborah Manganas, Hélène Fisher, Jolene H. Kolb, Martin R.J. Chen, Xiaoping Gibson, Kevin F. Kass, Daniel J. Zhang, Yingze Lindell, Kathleen O. Nouraie, S. Mehdi |
author_sort | Goobie, Gillian C. |
collection | PubMed |
description | BACKGROUND: This multicentre, international, prospective cohort study evaluated whether patients with pulmonary sarcoidosis living in neighbourhoods with greater material and social disadvantage experience worse clinical outcomes. METHODS: The area deprivation index and the Canadian Index of Multiple Deprivation evaluate neighbourhood-level disadvantage in the US and Canada, with higher scores reflecting greater disadvantage. Multivariable linear regression evaluated associations of disadvantage with baseline forced vital capacity (FVC) or diffusing capacity of the lung for carbon monoxide (D(LCO)) and linear mixed effects models for associations with rate of FVC or D(LCO) decline, and competing hazards models were used for survival analyses in the US cohort, evaluating competing outcomes of death or lung transplantation. Adjustments were made for age at diagnosis, sex, race and smoking history. RESULTS: We included 477 US and 122 Canadian patients with sarcoidosis. Higher disadvantage was not associated with survival or baseline FVC. The highest disadvantage quartile was associated with lower baseline D(LCO) in the US cohort (β = −6.80, 95% CI −13.16 to −0.44, p=0.04), with similar findings in the Canadian cohort (β = −7.47, 95% CI −20.28 to 5.33, p=0.25); with more rapid decline in FVC and D(LCO) in the US cohort (FVC β = −0.40, 95% CI −0.70 to −0.11, p=0.007; D(LCO) β = −0.59, 95% CI −0.95 to −0.23, p=0.001); and with more rapid FVC decline in the Canadian cohort (FVC β = −0.80, 95% CI −1.37 to −0.24, p=0.003). CONCLUSION: Patients with sarcoidosis living in high disadvantage neighbourhoods experience worse baseline lung function and more rapid lung function decline, highlighting the need for better understanding of how neighbourhood-level factors impact individual patient outcomes. |
format | Online Article Text |
id | pubmed-9589334 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | European Respiratory Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-95893342022-10-25 Neighbourhood disadvantage impacts on pulmonary function in patients with sarcoidosis Goobie, Gillian C. Ryerson, Christopher J. Johannson, Kerri A. Keil, Spencer Schikowski, Erin Khalil, Nasreen Marcoux, Veronica Assayag, Deborah Manganas, Hélène Fisher, Jolene H. Kolb, Martin R.J. Chen, Xiaoping Gibson, Kevin F. Kass, Daniel J. Zhang, Yingze Lindell, Kathleen O. Nouraie, S. Mehdi ERJ Open Res Original Research Articles BACKGROUND: This multicentre, international, prospective cohort study evaluated whether patients with pulmonary sarcoidosis living in neighbourhoods with greater material and social disadvantage experience worse clinical outcomes. METHODS: The area deprivation index and the Canadian Index of Multiple Deprivation evaluate neighbourhood-level disadvantage in the US and Canada, with higher scores reflecting greater disadvantage. Multivariable linear regression evaluated associations of disadvantage with baseline forced vital capacity (FVC) or diffusing capacity of the lung for carbon monoxide (D(LCO)) and linear mixed effects models for associations with rate of FVC or D(LCO) decline, and competing hazards models were used for survival analyses in the US cohort, evaluating competing outcomes of death or lung transplantation. Adjustments were made for age at diagnosis, sex, race and smoking history. RESULTS: We included 477 US and 122 Canadian patients with sarcoidosis. Higher disadvantage was not associated with survival or baseline FVC. The highest disadvantage quartile was associated with lower baseline D(LCO) in the US cohort (β = −6.80, 95% CI −13.16 to −0.44, p=0.04), with similar findings in the Canadian cohort (β = −7.47, 95% CI −20.28 to 5.33, p=0.25); with more rapid decline in FVC and D(LCO) in the US cohort (FVC β = −0.40, 95% CI −0.70 to −0.11, p=0.007; D(LCO) β = −0.59, 95% CI −0.95 to −0.23, p=0.001); and with more rapid FVC decline in the Canadian cohort (FVC β = −0.80, 95% CI −1.37 to −0.24, p=0.003). CONCLUSION: Patients with sarcoidosis living in high disadvantage neighbourhoods experience worse baseline lung function and more rapid lung function decline, highlighting the need for better understanding of how neighbourhood-level factors impact individual patient outcomes. European Respiratory Society 2022-10-24 /pmc/articles/PMC9589334/ /pubmed/36299359 http://dx.doi.org/10.1183/23120541.00357-2022 Text en Copyright ©The authors 2022 https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org (mailto:permissions@ersnet.org) |
spellingShingle | Original Research Articles Goobie, Gillian C. Ryerson, Christopher J. Johannson, Kerri A. Keil, Spencer Schikowski, Erin Khalil, Nasreen Marcoux, Veronica Assayag, Deborah Manganas, Hélène Fisher, Jolene H. Kolb, Martin R.J. Chen, Xiaoping Gibson, Kevin F. Kass, Daniel J. Zhang, Yingze Lindell, Kathleen O. Nouraie, S. Mehdi Neighbourhood disadvantage impacts on pulmonary function in patients with sarcoidosis |
title | Neighbourhood disadvantage impacts on pulmonary function in patients with sarcoidosis |
title_full | Neighbourhood disadvantage impacts on pulmonary function in patients with sarcoidosis |
title_fullStr | Neighbourhood disadvantage impacts on pulmonary function in patients with sarcoidosis |
title_full_unstemmed | Neighbourhood disadvantage impacts on pulmonary function in patients with sarcoidosis |
title_short | Neighbourhood disadvantage impacts on pulmonary function in patients with sarcoidosis |
title_sort | neighbourhood disadvantage impacts on pulmonary function in patients with sarcoidosis |
topic | Original Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589334/ https://www.ncbi.nlm.nih.gov/pubmed/36299359 http://dx.doi.org/10.1183/23120541.00357-2022 |
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