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Nuclear size rectification: A potential new therapeutic approach to reduce metastasis in cancer

Research on metastasis has recently regained considerable interest with the hope that single cell technologies might reveal the most critical changes that support tumor spread. However, it is possible that part of the answer has been visible through the microscope for close to 200 years. Changes in...

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Autores principales: Schirmer, Eric C., Latonen, Leena, Tollis, Sylvain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589484/
https://www.ncbi.nlm.nih.gov/pubmed/36299481
http://dx.doi.org/10.3389/fcell.2022.1022723
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author Schirmer, Eric C.
Latonen, Leena
Tollis, Sylvain
author_facet Schirmer, Eric C.
Latonen, Leena
Tollis, Sylvain
author_sort Schirmer, Eric C.
collection PubMed
description Research on metastasis has recently regained considerable interest with the hope that single cell technologies might reveal the most critical changes that support tumor spread. However, it is possible that part of the answer has been visible through the microscope for close to 200 years. Changes in nuclear size characteristically occur in many cancer types when the cells metastasize. This was initially discarded as contributing to the metastatic spread because, depending on tumor types, both increases and decreases in nuclear size could correlate with increased metastasis. However, recent work on nuclear mechanics and the connectivity between chromatin, the nucleoskeleton, and the cytoskeleton indicate that changes in this connectivity can have profound impacts on cell mobility and invasiveness. Critically, a recent study found that reversing tumor type-dependent nuclear size changes correlated with reduced cell migration and invasion. Accordingly, it seems appropriate to now revisit possible contributory roles of nuclear size changes to metastasis.
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spelling pubmed-95894842022-10-25 Nuclear size rectification: A potential new therapeutic approach to reduce metastasis in cancer Schirmer, Eric C. Latonen, Leena Tollis, Sylvain Front Cell Dev Biol Cell and Developmental Biology Research on metastasis has recently regained considerable interest with the hope that single cell technologies might reveal the most critical changes that support tumor spread. However, it is possible that part of the answer has been visible through the microscope for close to 200 years. Changes in nuclear size characteristically occur in many cancer types when the cells metastasize. This was initially discarded as contributing to the metastatic spread because, depending on tumor types, both increases and decreases in nuclear size could correlate with increased metastasis. However, recent work on nuclear mechanics and the connectivity between chromatin, the nucleoskeleton, and the cytoskeleton indicate that changes in this connectivity can have profound impacts on cell mobility and invasiveness. Critically, a recent study found that reversing tumor type-dependent nuclear size changes correlated with reduced cell migration and invasion. Accordingly, it seems appropriate to now revisit possible contributory roles of nuclear size changes to metastasis. Frontiers Media S.A. 2022-10-10 /pmc/articles/PMC9589484/ /pubmed/36299481 http://dx.doi.org/10.3389/fcell.2022.1022723 Text en Copyright © 2022 Schirmer, Latonen and Tollis. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Schirmer, Eric C.
Latonen, Leena
Tollis, Sylvain
Nuclear size rectification: A potential new therapeutic approach to reduce metastasis in cancer
title Nuclear size rectification: A potential new therapeutic approach to reduce metastasis in cancer
title_full Nuclear size rectification: A potential new therapeutic approach to reduce metastasis in cancer
title_fullStr Nuclear size rectification: A potential new therapeutic approach to reduce metastasis in cancer
title_full_unstemmed Nuclear size rectification: A potential new therapeutic approach to reduce metastasis in cancer
title_short Nuclear size rectification: A potential new therapeutic approach to reduce metastasis in cancer
title_sort nuclear size rectification: a potential new therapeutic approach to reduce metastasis in cancer
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589484/
https://www.ncbi.nlm.nih.gov/pubmed/36299481
http://dx.doi.org/10.3389/fcell.2022.1022723
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