Time is of the essence for vaccine success

Effective vaccines elicit neutralizing antibodies and long-lasting memory, but this can be challenging with some pathogens, such as HIV. A new study shows how a slow-delivery protein immunization strategy administered in dose-escalation format over 12 days increased the durability of germinal center...

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Detalles Bibliográficos
Autores principales: Quast, Isaak, Tarlinton, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
News & Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589732/
https://www.ncbi.nlm.nih.gov/pubmed/36271149
http://dx.doi.org/10.1038/s41590-022-01347-3
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author Quast, Isaak
Tarlinton, David
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Tarlinton, David
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description Effective vaccines elicit neutralizing antibodies and long-lasting memory, but this can be challenging with some pathogens, such as HIV. A new study shows how a slow-delivery protein immunization strategy administered in dose-escalation format over 12 days increased the durability of germinal centers and improved immunological outcomes.
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spelling pubmed-95897322022-10-24 Time is of the essence for vaccine success Quast, Isaak Tarlinton, David Nat Immunol News & Views Effective vaccines elicit neutralizing antibodies and long-lasting memory, but this can be challenging with some pathogens, such as HIV. A new study shows how a slow-delivery protein immunization strategy administered in dose-escalation format over 12 days increased the durability of germinal centers and improved immunological outcomes. Nature Publishing Group US 2022-10-21 2022 /pmc/articles/PMC9589732/ /pubmed/36271149 http://dx.doi.org/10.1038/s41590-022-01347-3 Text en © Springer Nature America, Inc. 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle News & Views
Quast, Isaak
Tarlinton, David
Time is of the essence for vaccine success
title Time is of the essence for vaccine success
title_full Time is of the essence for vaccine success
title_fullStr Time is of the essence for vaccine success
title_full_unstemmed Time is of the essence for vaccine success
title_short Time is of the essence for vaccine success
title_sort time is of the essence for vaccine success
topic News & Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589732/
https://www.ncbi.nlm.nih.gov/pubmed/36271149
http://dx.doi.org/10.1038/s41590-022-01347-3
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