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Pre-frail older adults show improved cognition with StayFitLonger computerized home–based training: a randomized controlled trial
Multidomain interventions have shown tremendous potential for improving cognition in older adults. It is unclear if multidomain interventions can be delivered remotely and whether remote intervention is beneficial for older adults who are vulnerable or at risk of cognitive decline. In a 26-week mult...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589849/ https://www.ncbi.nlm.nih.gov/pubmed/36266559 http://dx.doi.org/10.1007/s11357-022-00674-5 |
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author | Belleville, Sylvie Cuesta, M. Bieler-Aeschlimann, M. Giacomino, K. Widmer, A. Mittaz Hager, A. G. Perez-Marcos, D. Cardin, S. Boller, B. Bier, N. Aubertin-Leheudre, M. Bherer, L. Berryman, N. Agrigoroaei, S. Demonet, J. F. |
author_facet | Belleville, Sylvie Cuesta, M. Bieler-Aeschlimann, M. Giacomino, K. Widmer, A. Mittaz Hager, A. G. Perez-Marcos, D. Cardin, S. Boller, B. Bier, N. Aubertin-Leheudre, M. Bherer, L. Berryman, N. Agrigoroaei, S. Demonet, J. F. |
author_sort | Belleville, Sylvie |
collection | PubMed |
description | Multidomain interventions have shown tremendous potential for improving cognition in older adults. It is unclear if multidomain interventions can be delivered remotely and whether remote intervention is beneficial for older adults who are vulnerable or at risk of cognitive decline. In a 26-week multi-site, home-based, double-blind, randomized controlled trial, 120 cognitively healthy older adults (75 robust, 45 pre-frail; age range = 60–94) recruited from Switzerland, Canada, and Belgium were randomized to receive either the StayFitLonger (SFL) computerized multidomain training program or an active control intervention. Delivered on tablets, the SFL intervention combined adapted physical exercises (strength, balance, and mobility), cognitive training (divided attention, problem solving, and memory), opportunities for social and contributive interactions, and psychoeducation. The active control intervention provided basic mobilization exercises and access to video games. Cognitive outcomes were global cognition (Z-scores of attention, verbal fluency, and episodic memory for nondemented older adults; ZAVEN), memory, executive function, and processing speed. Linear mixed model analyses indicated improved performance on the ZAVEN global cognition score in the SFL group but not in the active control group. Stratified analyses by frailty status revealed improved ZAVEN global cognition and processing speed scores following SFL in the pre-frail group but not in the robust group. Overall, the study indicates that a computerized program providing a multidomain intervention at home can improve cognition in older adults. Importantly, pre-frail individuals, who are at higher risk of cognitive decline, seem to benefit more from the intervention. Trial registration: ClinicalTrials.gov, NCT037519 Registered on January 22, 2020—Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT04237519. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11357-022-00674-5. |
format | Online Article Text |
id | pubmed-9589849 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-95898492022-10-24 Pre-frail older adults show improved cognition with StayFitLonger computerized home–based training: a randomized controlled trial Belleville, Sylvie Cuesta, M. Bieler-Aeschlimann, M. Giacomino, K. Widmer, A. Mittaz Hager, A. G. Perez-Marcos, D. Cardin, S. Boller, B. Bier, N. Aubertin-Leheudre, M. Bherer, L. Berryman, N. Agrigoroaei, S. Demonet, J. F. GeroScience Original Article Multidomain interventions have shown tremendous potential for improving cognition in older adults. It is unclear if multidomain interventions can be delivered remotely and whether remote intervention is beneficial for older adults who are vulnerable or at risk of cognitive decline. In a 26-week multi-site, home-based, double-blind, randomized controlled trial, 120 cognitively healthy older adults (75 robust, 45 pre-frail; age range = 60–94) recruited from Switzerland, Canada, and Belgium were randomized to receive either the StayFitLonger (SFL) computerized multidomain training program or an active control intervention. Delivered on tablets, the SFL intervention combined adapted physical exercises (strength, balance, and mobility), cognitive training (divided attention, problem solving, and memory), opportunities for social and contributive interactions, and psychoeducation. The active control intervention provided basic mobilization exercises and access to video games. Cognitive outcomes were global cognition (Z-scores of attention, verbal fluency, and episodic memory for nondemented older adults; ZAVEN), memory, executive function, and processing speed. Linear mixed model analyses indicated improved performance on the ZAVEN global cognition score in the SFL group but not in the active control group. Stratified analyses by frailty status revealed improved ZAVEN global cognition and processing speed scores following SFL in the pre-frail group but not in the robust group. Overall, the study indicates that a computerized program providing a multidomain intervention at home can improve cognition in older adults. Importantly, pre-frail individuals, who are at higher risk of cognitive decline, seem to benefit more from the intervention. Trial registration: ClinicalTrials.gov, NCT037519 Registered on January 22, 2020—Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT04237519. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11357-022-00674-5. Springer International Publishing 2022-10-21 /pmc/articles/PMC9589849/ /pubmed/36266559 http://dx.doi.org/10.1007/s11357-022-00674-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Belleville, Sylvie Cuesta, M. Bieler-Aeschlimann, M. Giacomino, K. Widmer, A. Mittaz Hager, A. G. Perez-Marcos, D. Cardin, S. Boller, B. Bier, N. Aubertin-Leheudre, M. Bherer, L. Berryman, N. Agrigoroaei, S. Demonet, J. F. Pre-frail older adults show improved cognition with StayFitLonger computerized home–based training: a randomized controlled trial |
title | Pre-frail older adults show improved cognition with StayFitLonger computerized home–based training: a randomized controlled trial |
title_full | Pre-frail older adults show improved cognition with StayFitLonger computerized home–based training: a randomized controlled trial |
title_fullStr | Pre-frail older adults show improved cognition with StayFitLonger computerized home–based training: a randomized controlled trial |
title_full_unstemmed | Pre-frail older adults show improved cognition with StayFitLonger computerized home–based training: a randomized controlled trial |
title_short | Pre-frail older adults show improved cognition with StayFitLonger computerized home–based training: a randomized controlled trial |
title_sort | pre-frail older adults show improved cognition with stayfitlonger computerized home–based training: a randomized controlled trial |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589849/ https://www.ncbi.nlm.nih.gov/pubmed/36266559 http://dx.doi.org/10.1007/s11357-022-00674-5 |
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