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The functional role of p38 MAPK pathway in malignant brain tumors
Gliomas are extremely debilitating malignant brain tumors with very limited response to therapies. The initiation and progression of gliomas can be attributed to several molecular abnormalities, such as mutations in important regulatory networks. In this regard, the mitogen-activated protein kinases...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589890/ https://www.ncbi.nlm.nih.gov/pubmed/36299892 http://dx.doi.org/10.3389/fphar.2022.975197 |
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author | Grave, Nathália Scheffel, Thamiris Becker Cruz, Fernanda Fernandes Rockenbach, Liliana Goettert, Márcia Inês Laufer, Stefan Morrone, Fernanda Bueno |
author_facet | Grave, Nathália Scheffel, Thamiris Becker Cruz, Fernanda Fernandes Rockenbach, Liliana Goettert, Márcia Inês Laufer, Stefan Morrone, Fernanda Bueno |
author_sort | Grave, Nathália |
collection | PubMed |
description | Gliomas are extremely debilitating malignant brain tumors with very limited response to therapies. The initiation and progression of gliomas can be attributed to several molecular abnormalities, such as mutations in important regulatory networks. In this regard, the mitogen-activated protein kinases (MAPKs) arise as key signaling pathways involved in cell proliferation, survival, and differentiation. MAPK pathway has been altered in most glial tumors. In glioma cells, the activation of p38 MAPK contributes to tumor invasion and metastasis and is positively correlated with tumor grade, being considered a potential oncogenic factor contributing to brain tumorigenesis and chemotherapy resistance. Hence, a better understanding of glioma pathogenesis is essential to the advancement of therapies that provide extended life expectancy for glioma patients. This review aims to explore the role of the p38 MAPK pathway in the genesis and progression of malignant brain tumors. |
format | Online Article Text |
id | pubmed-9589890 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95898902022-10-25 The functional role of p38 MAPK pathway in malignant brain tumors Grave, Nathália Scheffel, Thamiris Becker Cruz, Fernanda Fernandes Rockenbach, Liliana Goettert, Márcia Inês Laufer, Stefan Morrone, Fernanda Bueno Front Pharmacol Pharmacology Gliomas are extremely debilitating malignant brain tumors with very limited response to therapies. The initiation and progression of gliomas can be attributed to several molecular abnormalities, such as mutations in important regulatory networks. In this regard, the mitogen-activated protein kinases (MAPKs) arise as key signaling pathways involved in cell proliferation, survival, and differentiation. MAPK pathway has been altered in most glial tumors. In glioma cells, the activation of p38 MAPK contributes to tumor invasion and metastasis and is positively correlated with tumor grade, being considered a potential oncogenic factor contributing to brain tumorigenesis and chemotherapy resistance. Hence, a better understanding of glioma pathogenesis is essential to the advancement of therapies that provide extended life expectancy for glioma patients. This review aims to explore the role of the p38 MAPK pathway in the genesis and progression of malignant brain tumors. Frontiers Media S.A. 2022-10-03 /pmc/articles/PMC9589890/ /pubmed/36299892 http://dx.doi.org/10.3389/fphar.2022.975197 Text en Copyright © 2022 Grave, Scheffel, Cruz, Rockenbach, Goettert, Laufer and Morrone. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Grave, Nathália Scheffel, Thamiris Becker Cruz, Fernanda Fernandes Rockenbach, Liliana Goettert, Márcia Inês Laufer, Stefan Morrone, Fernanda Bueno The functional role of p38 MAPK pathway in malignant brain tumors |
title | The functional role of p38 MAPK pathway in malignant brain tumors |
title_full | The functional role of p38 MAPK pathway in malignant brain tumors |
title_fullStr | The functional role of p38 MAPK pathway in malignant brain tumors |
title_full_unstemmed | The functional role of p38 MAPK pathway in malignant brain tumors |
title_short | The functional role of p38 MAPK pathway in malignant brain tumors |
title_sort | functional role of p38 mapk pathway in malignant brain tumors |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589890/ https://www.ncbi.nlm.nih.gov/pubmed/36299892 http://dx.doi.org/10.3389/fphar.2022.975197 |
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