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Characterization of fatty acid metabolism-related lncRNAs in lung adenocarcinoma identifying potential novel prognostic targets
Lung adenocarcinoma (LUAD), a malignant respiratory tumor with an extremely poor prognosis, has troubled the medical community all over the world. According to recent studies, fatty acid metabolism (FAM) and long non-coding RNAs (lncRNAs) regulation have shown exciting results in tumor therapy. In t...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589892/ https://www.ncbi.nlm.nih.gov/pubmed/36299578 http://dx.doi.org/10.3389/fgene.2022.990153 |
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author | Liu, Yang Zhang, Xingshu Cheng, Xuechao Luo, Qian Yu, Mingyang Long, Kaijun Qu, Wendong Tang, Yang Gong, Ming Liang, Lubiao Ke, Xixian Song, Yongxiang |
author_facet | Liu, Yang Zhang, Xingshu Cheng, Xuechao Luo, Qian Yu, Mingyang Long, Kaijun Qu, Wendong Tang, Yang Gong, Ming Liang, Lubiao Ke, Xixian Song, Yongxiang |
author_sort | Liu, Yang |
collection | PubMed |
description | Lung adenocarcinoma (LUAD), a malignant respiratory tumor with an extremely poor prognosis, has troubled the medical community all over the world. According to recent studies, fatty acid metabolism (FAM) and long non-coding RNAs (lncRNAs) regulation have shown exciting results in tumor therapy. In this study, the original LUAD patient data was obtained from the TCGA database, and 12 FAM-related lncRNAs (AL390755.1, AC105020.6, TMPO-AS1, AC016737.2, AC127070.2, LINC01281, AL589986.2, GAS6-DT, AC078993.1, LINC02198, AC007032.1, and AL021026.1) that were highly related to the progression of LUAD were finally identified through bioinformatics analysis, and a risk score model for clinical reference was constructed. The window explores the immunology and molecular mechanism of LUAD, aiming to shed the hoping light on LUAD treatment. |
format | Online Article Text |
id | pubmed-9589892 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95898922022-10-25 Characterization of fatty acid metabolism-related lncRNAs in lung adenocarcinoma identifying potential novel prognostic targets Liu, Yang Zhang, Xingshu Cheng, Xuechao Luo, Qian Yu, Mingyang Long, Kaijun Qu, Wendong Tang, Yang Gong, Ming Liang, Lubiao Ke, Xixian Song, Yongxiang Front Genet Genetics Lung adenocarcinoma (LUAD), a malignant respiratory tumor with an extremely poor prognosis, has troubled the medical community all over the world. According to recent studies, fatty acid metabolism (FAM) and long non-coding RNAs (lncRNAs) regulation have shown exciting results in tumor therapy. In this study, the original LUAD patient data was obtained from the TCGA database, and 12 FAM-related lncRNAs (AL390755.1, AC105020.6, TMPO-AS1, AC016737.2, AC127070.2, LINC01281, AL589986.2, GAS6-DT, AC078993.1, LINC02198, AC007032.1, and AL021026.1) that were highly related to the progression of LUAD were finally identified through bioinformatics analysis, and a risk score model for clinical reference was constructed. The window explores the immunology and molecular mechanism of LUAD, aiming to shed the hoping light on LUAD treatment. Frontiers Media S.A. 2022-09-27 /pmc/articles/PMC9589892/ /pubmed/36299578 http://dx.doi.org/10.3389/fgene.2022.990153 Text en Copyright © 2022 Liu, Zhang, Cheng, Luo, Yu, Long, Qu, Tang, Gong, Liang, Ke and Song. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Liu, Yang Zhang, Xingshu Cheng, Xuechao Luo, Qian Yu, Mingyang Long, Kaijun Qu, Wendong Tang, Yang Gong, Ming Liang, Lubiao Ke, Xixian Song, Yongxiang Characterization of fatty acid metabolism-related lncRNAs in lung adenocarcinoma identifying potential novel prognostic targets |
title | Characterization of fatty acid metabolism-related lncRNAs in lung adenocarcinoma identifying potential novel prognostic targets |
title_full | Characterization of fatty acid metabolism-related lncRNAs in lung adenocarcinoma identifying potential novel prognostic targets |
title_fullStr | Characterization of fatty acid metabolism-related lncRNAs in lung adenocarcinoma identifying potential novel prognostic targets |
title_full_unstemmed | Characterization of fatty acid metabolism-related lncRNAs in lung adenocarcinoma identifying potential novel prognostic targets |
title_short | Characterization of fatty acid metabolism-related lncRNAs in lung adenocarcinoma identifying potential novel prognostic targets |
title_sort | characterization of fatty acid metabolism-related lncrnas in lung adenocarcinoma identifying potential novel prognostic targets |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589892/ https://www.ncbi.nlm.nih.gov/pubmed/36299578 http://dx.doi.org/10.3389/fgene.2022.990153 |
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