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Characterization of fatty acid metabolism-related lncRNAs in lung adenocarcinoma identifying potential novel prognostic targets

Lung adenocarcinoma (LUAD), a malignant respiratory tumor with an extremely poor prognosis, has troubled the medical community all over the world. According to recent studies, fatty acid metabolism (FAM) and long non-coding RNAs (lncRNAs) regulation have shown exciting results in tumor therapy. In t...

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Autores principales: Liu, Yang, Zhang, Xingshu, Cheng, Xuechao, Luo, Qian, Yu, Mingyang, Long, Kaijun, Qu, Wendong, Tang, Yang, Gong, Ming, Liang, Lubiao, Ke, Xixian, Song, Yongxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589892/
https://www.ncbi.nlm.nih.gov/pubmed/36299578
http://dx.doi.org/10.3389/fgene.2022.990153
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author Liu, Yang
Zhang, Xingshu
Cheng, Xuechao
Luo, Qian
Yu, Mingyang
Long, Kaijun
Qu, Wendong
Tang, Yang
Gong, Ming
Liang, Lubiao
Ke, Xixian
Song, Yongxiang
author_facet Liu, Yang
Zhang, Xingshu
Cheng, Xuechao
Luo, Qian
Yu, Mingyang
Long, Kaijun
Qu, Wendong
Tang, Yang
Gong, Ming
Liang, Lubiao
Ke, Xixian
Song, Yongxiang
author_sort Liu, Yang
collection PubMed
description Lung adenocarcinoma (LUAD), a malignant respiratory tumor with an extremely poor prognosis, has troubled the medical community all over the world. According to recent studies, fatty acid metabolism (FAM) and long non-coding RNAs (lncRNAs) regulation have shown exciting results in tumor therapy. In this study, the original LUAD patient data was obtained from the TCGA database, and 12 FAM-related lncRNAs (AL390755.1, AC105020.6, TMPO-AS1, AC016737.2, AC127070.2, LINC01281, AL589986.2, GAS6-DT, AC078993.1, LINC02198, AC007032.1, and AL021026.1) that were highly related to the progression of LUAD were finally identified through bioinformatics analysis, and a risk score model for clinical reference was constructed. The window explores the immunology and molecular mechanism of LUAD, aiming to shed the hoping light on LUAD treatment.
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spelling pubmed-95898922022-10-25 Characterization of fatty acid metabolism-related lncRNAs in lung adenocarcinoma identifying potential novel prognostic targets Liu, Yang Zhang, Xingshu Cheng, Xuechao Luo, Qian Yu, Mingyang Long, Kaijun Qu, Wendong Tang, Yang Gong, Ming Liang, Lubiao Ke, Xixian Song, Yongxiang Front Genet Genetics Lung adenocarcinoma (LUAD), a malignant respiratory tumor with an extremely poor prognosis, has troubled the medical community all over the world. According to recent studies, fatty acid metabolism (FAM) and long non-coding RNAs (lncRNAs) regulation have shown exciting results in tumor therapy. In this study, the original LUAD patient data was obtained from the TCGA database, and 12 FAM-related lncRNAs (AL390755.1, AC105020.6, TMPO-AS1, AC016737.2, AC127070.2, LINC01281, AL589986.2, GAS6-DT, AC078993.1, LINC02198, AC007032.1, and AL021026.1) that were highly related to the progression of LUAD were finally identified through bioinformatics analysis, and a risk score model for clinical reference was constructed. The window explores the immunology and molecular mechanism of LUAD, aiming to shed the hoping light on LUAD treatment. Frontiers Media S.A. 2022-09-27 /pmc/articles/PMC9589892/ /pubmed/36299578 http://dx.doi.org/10.3389/fgene.2022.990153 Text en Copyright © 2022 Liu, Zhang, Cheng, Luo, Yu, Long, Qu, Tang, Gong, Liang, Ke and Song. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Liu, Yang
Zhang, Xingshu
Cheng, Xuechao
Luo, Qian
Yu, Mingyang
Long, Kaijun
Qu, Wendong
Tang, Yang
Gong, Ming
Liang, Lubiao
Ke, Xixian
Song, Yongxiang
Characterization of fatty acid metabolism-related lncRNAs in lung adenocarcinoma identifying potential novel prognostic targets
title Characterization of fatty acid metabolism-related lncRNAs in lung adenocarcinoma identifying potential novel prognostic targets
title_full Characterization of fatty acid metabolism-related lncRNAs in lung adenocarcinoma identifying potential novel prognostic targets
title_fullStr Characterization of fatty acid metabolism-related lncRNAs in lung adenocarcinoma identifying potential novel prognostic targets
title_full_unstemmed Characterization of fatty acid metabolism-related lncRNAs in lung adenocarcinoma identifying potential novel prognostic targets
title_short Characterization of fatty acid metabolism-related lncRNAs in lung adenocarcinoma identifying potential novel prognostic targets
title_sort characterization of fatty acid metabolism-related lncrnas in lung adenocarcinoma identifying potential novel prognostic targets
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589892/
https://www.ncbi.nlm.nih.gov/pubmed/36299578
http://dx.doi.org/10.3389/fgene.2022.990153
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