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IgY Antibodies as Biotherapeutics in Biomedicine

Since the discovery of antibodies by Emil Von Behring and Shibasaburo Kitasato during the 19th century, their potential for use as biotechnological reagents has been exploited in different fields, such as basic and applied research, diagnosis, and the treatment of multiple diseases. Antibodies are r...

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Autores principales: León-Núñez, Diana, Vizcaíno-López, María Fernanda, Escorcia, Magdalena, Correa, Dolores, Pérez-Hernández, Elizabeth, Gómez-Chávez, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590010/
https://www.ncbi.nlm.nih.gov/pubmed/36278615
http://dx.doi.org/10.3390/antib11040062
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author León-Núñez, Diana
Vizcaíno-López, María Fernanda
Escorcia, Magdalena
Correa, Dolores
Pérez-Hernández, Elizabeth
Gómez-Chávez, Fernando
author_facet León-Núñez, Diana
Vizcaíno-López, María Fernanda
Escorcia, Magdalena
Correa, Dolores
Pérez-Hernández, Elizabeth
Gómez-Chávez, Fernando
author_sort León-Núñez, Diana
collection PubMed
description Since the discovery of antibodies by Emil Von Behring and Shibasaburo Kitasato during the 19th century, their potential for use as biotechnological reagents has been exploited in different fields, such as basic and applied research, diagnosis, and the treatment of multiple diseases. Antibodies are relatively easy to obtain from any species with an adaptive immune system, but birds are animals characterized by relatively easy care and maintenance. In addition, the antibodies they produce can be purified from the egg yolk, allowing a system for obtaining them without performing invasive practices, which favors the three “rs” of animal care in experimentation, i.e., replacing, reducing, and refining. In this work, we carry out a brief descriptive review of the most outstanding characteristics of so-called “IgY technology” and the use of IgY antibodies from birds for basic experimentation, diagnosis, and treatment of human beings and animals.
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spelling pubmed-95900102022-10-25 IgY Antibodies as Biotherapeutics in Biomedicine León-Núñez, Diana Vizcaíno-López, María Fernanda Escorcia, Magdalena Correa, Dolores Pérez-Hernández, Elizabeth Gómez-Chávez, Fernando Antibodies (Basel) Review Since the discovery of antibodies by Emil Von Behring and Shibasaburo Kitasato during the 19th century, their potential for use as biotechnological reagents has been exploited in different fields, such as basic and applied research, diagnosis, and the treatment of multiple diseases. Antibodies are relatively easy to obtain from any species with an adaptive immune system, but birds are animals characterized by relatively easy care and maintenance. In addition, the antibodies they produce can be purified from the egg yolk, allowing a system for obtaining them without performing invasive practices, which favors the three “rs” of animal care in experimentation, i.e., replacing, reducing, and refining. In this work, we carry out a brief descriptive review of the most outstanding characteristics of so-called “IgY technology” and the use of IgY antibodies from birds for basic experimentation, diagnosis, and treatment of human beings and animals. MDPI 2022-09-29 /pmc/articles/PMC9590010/ /pubmed/36278615 http://dx.doi.org/10.3390/antib11040062 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
León-Núñez, Diana
Vizcaíno-López, María Fernanda
Escorcia, Magdalena
Correa, Dolores
Pérez-Hernández, Elizabeth
Gómez-Chávez, Fernando
IgY Antibodies as Biotherapeutics in Biomedicine
title IgY Antibodies as Biotherapeutics in Biomedicine
title_full IgY Antibodies as Biotherapeutics in Biomedicine
title_fullStr IgY Antibodies as Biotherapeutics in Biomedicine
title_full_unstemmed IgY Antibodies as Biotherapeutics in Biomedicine
title_short IgY Antibodies as Biotherapeutics in Biomedicine
title_sort igy antibodies as biotherapeutics in biomedicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590010/
https://www.ncbi.nlm.nih.gov/pubmed/36278615
http://dx.doi.org/10.3390/antib11040062
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