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Immense Tumor of Maxillary Sinus with Exophthalmos—A Rare Underlying Cause
Sinus tumors are arduous to diagnose due to often prolonging asymptomatic course until the infiltration of the adjacent structures occurs. Therefore, patients are diagnosed with advanced-stage disease, which negatively affects the treatment outcomes. A 60-year-old male was referred to our ward from...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590070/ https://www.ncbi.nlm.nih.gov/pubmed/36278521 http://dx.doi.org/10.3390/hematolrep14040044 |
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author | Lesniewska-Skowerska, Olga Symela-Kaspera, Joanna Klimczak-Gołąb, Lucyna Smolka, Wojciech Markowski, Jaroslaw |
author_facet | Lesniewska-Skowerska, Olga Symela-Kaspera, Joanna Klimczak-Gołąb, Lucyna Smolka, Wojciech Markowski, Jaroslaw |
author_sort | Lesniewska-Skowerska, Olga |
collection | PubMed |
description | Sinus tumors are arduous to diagnose due to often prolonging asymptomatic course until the infiltration of the adjacent structures occurs. Therefore, patients are diagnosed with advanced-stage disease, which negatively affects the treatment outcomes. A 60-year-old male was referred to our ward from an outpatient clinic. The patient presented with double vision, right-side lacrimation, and exophthalmos. He also reported significant weight loss: 15 kg in 2 months. Physical examination revealed achiness and edema of the right temporal area, and subconjunctival hemorrhage of the right eye, and surprisingly no anosmia, no nasal obstruction, and no head/neck lymphadenopathy were present. The histopathology examination identified diffuse large B-cell lymphoma (CD20+ CD3- p63- bcl-2+ CD23-/+ bcl-6+ CD 10- MUM1+ Tdt- CD38- cyclin D1- CD30- c-myc+). The patient was qualified for R-CHOP immunochemotherapy (rituximab, cyclophosphamide, and hydroxydaunorubicin hydrochloride), which was well tolerated. After 3 months of treatment, all of the symptoms reversed and a whole-body PET scan showed no abnormal metabolic activity. |
format | Online Article Text |
id | pubmed-9590070 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95900702022-10-25 Immense Tumor of Maxillary Sinus with Exophthalmos—A Rare Underlying Cause Lesniewska-Skowerska, Olga Symela-Kaspera, Joanna Klimczak-Gołąb, Lucyna Smolka, Wojciech Markowski, Jaroslaw Hematol Rep Case Report Sinus tumors are arduous to diagnose due to often prolonging asymptomatic course until the infiltration of the adjacent structures occurs. Therefore, patients are diagnosed with advanced-stage disease, which negatively affects the treatment outcomes. A 60-year-old male was referred to our ward from an outpatient clinic. The patient presented with double vision, right-side lacrimation, and exophthalmos. He also reported significant weight loss: 15 kg in 2 months. Physical examination revealed achiness and edema of the right temporal area, and subconjunctival hemorrhage of the right eye, and surprisingly no anosmia, no nasal obstruction, and no head/neck lymphadenopathy were present. The histopathology examination identified diffuse large B-cell lymphoma (CD20+ CD3- p63- bcl-2+ CD23-/+ bcl-6+ CD 10- MUM1+ Tdt- CD38- cyclin D1- CD30- c-myc+). The patient was qualified for R-CHOP immunochemotherapy (rituximab, cyclophosphamide, and hydroxydaunorubicin hydrochloride), which was well tolerated. After 3 months of treatment, all of the symptoms reversed and a whole-body PET scan showed no abnormal metabolic activity. MDPI 2022-10-10 /pmc/articles/PMC9590070/ /pubmed/36278521 http://dx.doi.org/10.3390/hematolrep14040044 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Lesniewska-Skowerska, Olga Symela-Kaspera, Joanna Klimczak-Gołąb, Lucyna Smolka, Wojciech Markowski, Jaroslaw Immense Tumor of Maxillary Sinus with Exophthalmos—A Rare Underlying Cause |
title | Immense Tumor of Maxillary Sinus with Exophthalmos—A Rare Underlying Cause |
title_full | Immense Tumor of Maxillary Sinus with Exophthalmos—A Rare Underlying Cause |
title_fullStr | Immense Tumor of Maxillary Sinus with Exophthalmos—A Rare Underlying Cause |
title_full_unstemmed | Immense Tumor of Maxillary Sinus with Exophthalmos—A Rare Underlying Cause |
title_short | Immense Tumor of Maxillary Sinus with Exophthalmos—A Rare Underlying Cause |
title_sort | immense tumor of maxillary sinus with exophthalmos—a rare underlying cause |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590070/ https://www.ncbi.nlm.nih.gov/pubmed/36278521 http://dx.doi.org/10.3390/hematolrep14040044 |
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