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Immense Tumor of Maxillary Sinus with Exophthalmos—A Rare Underlying Cause

Sinus tumors are arduous to diagnose due to often prolonging asymptomatic course until the infiltration of the adjacent structures occurs. Therefore, patients are diagnosed with advanced-stage disease, which negatively affects the treatment outcomes. A 60-year-old male was referred to our ward from...

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Autores principales: Lesniewska-Skowerska, Olga, Symela-Kaspera, Joanna, Klimczak-Gołąb, Lucyna, Smolka, Wojciech, Markowski, Jaroslaw
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590070/
https://www.ncbi.nlm.nih.gov/pubmed/36278521
http://dx.doi.org/10.3390/hematolrep14040044
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author Lesniewska-Skowerska, Olga
Symela-Kaspera, Joanna
Klimczak-Gołąb, Lucyna
Smolka, Wojciech
Markowski, Jaroslaw
author_facet Lesniewska-Skowerska, Olga
Symela-Kaspera, Joanna
Klimczak-Gołąb, Lucyna
Smolka, Wojciech
Markowski, Jaroslaw
author_sort Lesniewska-Skowerska, Olga
collection PubMed
description Sinus tumors are arduous to diagnose due to often prolonging asymptomatic course until the infiltration of the adjacent structures occurs. Therefore, patients are diagnosed with advanced-stage disease, which negatively affects the treatment outcomes. A 60-year-old male was referred to our ward from an outpatient clinic. The patient presented with double vision, right-side lacrimation, and exophthalmos. He also reported significant weight loss: 15 kg in 2 months. Physical examination revealed achiness and edema of the right temporal area, and subconjunctival hemorrhage of the right eye, and surprisingly no anosmia, no nasal obstruction, and no head/neck lymphadenopathy were present. The histopathology examination identified diffuse large B-cell lymphoma (CD20+ CD3- p63- bcl-2+ CD23-/+ bcl-6+ CD 10- MUM1+ Tdt- CD38- cyclin D1- CD30- c-myc+). The patient was qualified for R-CHOP immunochemotherapy (rituximab, cyclophosphamide, and hydroxydaunorubicin hydrochloride), which was well tolerated. After 3 months of treatment, all of the symptoms reversed and a whole-body PET scan showed no abnormal metabolic activity.
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spelling pubmed-95900702022-10-25 Immense Tumor of Maxillary Sinus with Exophthalmos—A Rare Underlying Cause Lesniewska-Skowerska, Olga Symela-Kaspera, Joanna Klimczak-Gołąb, Lucyna Smolka, Wojciech Markowski, Jaroslaw Hematol Rep Case Report Sinus tumors are arduous to diagnose due to often prolonging asymptomatic course until the infiltration of the adjacent structures occurs. Therefore, patients are diagnosed with advanced-stage disease, which negatively affects the treatment outcomes. A 60-year-old male was referred to our ward from an outpatient clinic. The patient presented with double vision, right-side lacrimation, and exophthalmos. He also reported significant weight loss: 15 kg in 2 months. Physical examination revealed achiness and edema of the right temporal area, and subconjunctival hemorrhage of the right eye, and surprisingly no anosmia, no nasal obstruction, and no head/neck lymphadenopathy were present. The histopathology examination identified diffuse large B-cell lymphoma (CD20+ CD3- p63- bcl-2+ CD23-/+ bcl-6+ CD 10- MUM1+ Tdt- CD38- cyclin D1- CD30- c-myc+). The patient was qualified for R-CHOP immunochemotherapy (rituximab, cyclophosphamide, and hydroxydaunorubicin hydrochloride), which was well tolerated. After 3 months of treatment, all of the symptoms reversed and a whole-body PET scan showed no abnormal metabolic activity. MDPI 2022-10-10 /pmc/articles/PMC9590070/ /pubmed/36278521 http://dx.doi.org/10.3390/hematolrep14040044 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Lesniewska-Skowerska, Olga
Symela-Kaspera, Joanna
Klimczak-Gołąb, Lucyna
Smolka, Wojciech
Markowski, Jaroslaw
Immense Tumor of Maxillary Sinus with Exophthalmos—A Rare Underlying Cause
title Immense Tumor of Maxillary Sinus with Exophthalmos—A Rare Underlying Cause
title_full Immense Tumor of Maxillary Sinus with Exophthalmos—A Rare Underlying Cause
title_fullStr Immense Tumor of Maxillary Sinus with Exophthalmos—A Rare Underlying Cause
title_full_unstemmed Immense Tumor of Maxillary Sinus with Exophthalmos—A Rare Underlying Cause
title_short Immense Tumor of Maxillary Sinus with Exophthalmos—A Rare Underlying Cause
title_sort immense tumor of maxillary sinus with exophthalmos—a rare underlying cause
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590070/
https://www.ncbi.nlm.nih.gov/pubmed/36278521
http://dx.doi.org/10.3390/hematolrep14040044
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