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Goblet Cell Carcinoma of the Appendix with Synchronous Adenocarcinoma of the Cecum: Distinct or Related Entities?

Goblet cell carcinoma (GCC) is a rare primary tumor of the appendix characterized by both epithelial and neuroendocrine components containing goblet cells. While in the past, the GCC has been associated with neuroendocrine tumors, recent studies consider that GCC is closer to adenocarcinoma than a n...

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Autores principales: Vincenti, Leonardo, Andriola, Valeria, Cazzato, Gerardo, Colagrande, Anna, Fiore, Felicia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590081/
https://www.ncbi.nlm.nih.gov/pubmed/36278575
http://dx.doi.org/10.3390/diseases10040077
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author Vincenti, Leonardo
Andriola, Valeria
Cazzato, Gerardo
Colagrande, Anna
Fiore, Felicia
author_facet Vincenti, Leonardo
Andriola, Valeria
Cazzato, Gerardo
Colagrande, Anna
Fiore, Felicia
author_sort Vincenti, Leonardo
collection PubMed
description Goblet cell carcinoma (GCC) is a rare primary tumor of the appendix characterized by both epithelial and neuroendocrine components containing goblet cells. While in the past, the GCC has been associated with neuroendocrine tumors, recent studies consider that GCC is closer to adenocarcinoma than a neuroendocrine component. The association between gastro-intestinal (GI) carcinoids and second primary malignancies (SPMs) is widely described in the literature, but there is no reported case of GCC and synchronous adjacent adenocarcinoma of the colon. We describe the first case in the literature, to our knowledge, of synchronous colorectal adenocarcinoma of the cecum and GCC of the appendix that are incidentally discovered in the resected primary cancer specimen. The association between the two neoplasms seems to be not causal and maybe the “paracrine-effect theory” may explain the development of a second tumor close to the primary.
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spelling pubmed-95900812022-10-25 Goblet Cell Carcinoma of the Appendix with Synchronous Adenocarcinoma of the Cecum: Distinct or Related Entities? Vincenti, Leonardo Andriola, Valeria Cazzato, Gerardo Colagrande, Anna Fiore, Felicia Diseases Communication Goblet cell carcinoma (GCC) is a rare primary tumor of the appendix characterized by both epithelial and neuroendocrine components containing goblet cells. While in the past, the GCC has been associated with neuroendocrine tumors, recent studies consider that GCC is closer to adenocarcinoma than a neuroendocrine component. The association between gastro-intestinal (GI) carcinoids and second primary malignancies (SPMs) is widely described in the literature, but there is no reported case of GCC and synchronous adjacent adenocarcinoma of the colon. We describe the first case in the literature, to our knowledge, of synchronous colorectal adenocarcinoma of the cecum and GCC of the appendix that are incidentally discovered in the resected primary cancer specimen. The association between the two neoplasms seems to be not causal and maybe the “paracrine-effect theory” may explain the development of a second tumor close to the primary. MDPI 2022-10-03 /pmc/articles/PMC9590081/ /pubmed/36278575 http://dx.doi.org/10.3390/diseases10040077 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Vincenti, Leonardo
Andriola, Valeria
Cazzato, Gerardo
Colagrande, Anna
Fiore, Felicia
Goblet Cell Carcinoma of the Appendix with Synchronous Adenocarcinoma of the Cecum: Distinct or Related Entities?
title Goblet Cell Carcinoma of the Appendix with Synchronous Adenocarcinoma of the Cecum: Distinct or Related Entities?
title_full Goblet Cell Carcinoma of the Appendix with Synchronous Adenocarcinoma of the Cecum: Distinct or Related Entities?
title_fullStr Goblet Cell Carcinoma of the Appendix with Synchronous Adenocarcinoma of the Cecum: Distinct or Related Entities?
title_full_unstemmed Goblet Cell Carcinoma of the Appendix with Synchronous Adenocarcinoma of the Cecum: Distinct or Related Entities?
title_short Goblet Cell Carcinoma of the Appendix with Synchronous Adenocarcinoma of the Cecum: Distinct or Related Entities?
title_sort goblet cell carcinoma of the appendix with synchronous adenocarcinoma of the cecum: distinct or related entities?
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590081/
https://www.ncbi.nlm.nih.gov/pubmed/36278575
http://dx.doi.org/10.3390/diseases10040077
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