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Characteristics of Ag-incorporated bioactive glasses prepared by a modified sol–gel method with a shortened synthesis time and without the use of catalysts
This work presents the preparation of bioactive glasses 70SiO(2)–(26 − x)CaO–4P(2)O(5)–xAg(2)O (with x = 0, 1, 3, 10 mol%) by a modified sol–gel method with reduced synthesis time based on hydrothermal reaction in a medium without acid or base catalysts. The synthetic materials were characterized by...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590098/ https://www.ncbi.nlm.nih.gov/pubmed/36329943 http://dx.doi.org/10.1039/d2ra05671b |
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author | Hoa, Bui Thi Phuc, Le Hong Hien, Nguyen Quan Vinh, Le Khanh Tien, Nguyen Anh Hiep, Dang Tan Vi, Vo Thuy Ly, Dang Ngoc Long, Nguyen Viet Hieu, Tran Trung Linh, Le Viet Minh, Nguyen Tuyet Xuan Vuong, Bui |
author_facet | Hoa, Bui Thi Phuc, Le Hong Hien, Nguyen Quan Vinh, Le Khanh Tien, Nguyen Anh Hiep, Dang Tan Vi, Vo Thuy Ly, Dang Ngoc Long, Nguyen Viet Hieu, Tran Trung Linh, Le Viet Minh, Nguyen Tuyet Xuan Vuong, Bui |
author_sort | Hoa, Bui Thi |
collection | PubMed |
description | This work presents the preparation of bioactive glasses 70SiO(2)–(26 − x)CaO–4P(2)O(5)–xAg(2)O (with x = 0, 1, 3, 10 mol%) by a modified sol–gel method with reduced synthesis time based on hydrothermal reaction in a medium without acid or base catalysts. The synthetic materials were characterized by several physical–chemical techniques such as TG-DSC, XRD, SEM, TEM, and N(2) adsorption/desorption measurement. The analysis data confirmed that the glass sample not containing Ag has a completely amorphous structure, while glass samples containing Ag exhibited a pure phase of metallic nano-silver in the glass amorphous phase. All the synthetic glasses have mesoporous structures with particle sizes of less than 30 nm. The addition of silver to the bioactive glass structure in general did not drastically reduce the specific surface areas and pore volumes of glasses as in previous studies. The bioactivity of the silver-incorporated glasses did not reduce, and even increased in the cases of bioactive glass containing 3, and 10 mol% of Ag(2)O. The biocompatibility of synthetic glasses with fibroblast cells (L-929) was confirmed, even with glass containing high amounts of Ag. Representatively, Ag-incorporated glass samples (sample x = 3, and x = 10) were selected to check the antibacterial ability using bacterial strain Pseudomonas aeruginosa ATCC 27853 (Pa). The obtained results indicated that these glasses exhibited good antibacterial ability to Pseudomonas aeruginosa. Thus, the synthetic method in this study proved to be a fast, environmentally friendly technique for synthesizing Ag-incorporated glass systems. The synthesized glasses show good bioactive, biocompatible, and antibacterial properties. |
format | Online Article Text |
id | pubmed-9590098 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-95900982022-11-02 Characteristics of Ag-incorporated bioactive glasses prepared by a modified sol–gel method with a shortened synthesis time and without the use of catalysts Hoa, Bui Thi Phuc, Le Hong Hien, Nguyen Quan Vinh, Le Khanh Tien, Nguyen Anh Hiep, Dang Tan Vi, Vo Thuy Ly, Dang Ngoc Long, Nguyen Viet Hieu, Tran Trung Linh, Le Viet Minh, Nguyen Tuyet Xuan Vuong, Bui RSC Adv Chemistry This work presents the preparation of bioactive glasses 70SiO(2)–(26 − x)CaO–4P(2)O(5)–xAg(2)O (with x = 0, 1, 3, 10 mol%) by a modified sol–gel method with reduced synthesis time based on hydrothermal reaction in a medium without acid or base catalysts. The synthetic materials were characterized by several physical–chemical techniques such as TG-DSC, XRD, SEM, TEM, and N(2) adsorption/desorption measurement. The analysis data confirmed that the glass sample not containing Ag has a completely amorphous structure, while glass samples containing Ag exhibited a pure phase of metallic nano-silver in the glass amorphous phase. All the synthetic glasses have mesoporous structures with particle sizes of less than 30 nm. The addition of silver to the bioactive glass structure in general did not drastically reduce the specific surface areas and pore volumes of glasses as in previous studies. The bioactivity of the silver-incorporated glasses did not reduce, and even increased in the cases of bioactive glass containing 3, and 10 mol% of Ag(2)O. The biocompatibility of synthetic glasses with fibroblast cells (L-929) was confirmed, even with glass containing high amounts of Ag. Representatively, Ag-incorporated glass samples (sample x = 3, and x = 10) were selected to check the antibacterial ability using bacterial strain Pseudomonas aeruginosa ATCC 27853 (Pa). The obtained results indicated that these glasses exhibited good antibacterial ability to Pseudomonas aeruginosa. Thus, the synthetic method in this study proved to be a fast, environmentally friendly technique for synthesizing Ag-incorporated glass systems. The synthesized glasses show good bioactive, biocompatible, and antibacterial properties. The Royal Society of Chemistry 2022-10-24 /pmc/articles/PMC9590098/ /pubmed/36329943 http://dx.doi.org/10.1039/d2ra05671b Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Chemistry Hoa, Bui Thi Phuc, Le Hong Hien, Nguyen Quan Vinh, Le Khanh Tien, Nguyen Anh Hiep, Dang Tan Vi, Vo Thuy Ly, Dang Ngoc Long, Nguyen Viet Hieu, Tran Trung Linh, Le Viet Minh, Nguyen Tuyet Xuan Vuong, Bui Characteristics of Ag-incorporated bioactive glasses prepared by a modified sol–gel method with a shortened synthesis time and without the use of catalysts |
title | Characteristics of Ag-incorporated bioactive glasses prepared by a modified sol–gel method with a shortened synthesis time and without the use of catalysts |
title_full | Characteristics of Ag-incorporated bioactive glasses prepared by a modified sol–gel method with a shortened synthesis time and without the use of catalysts |
title_fullStr | Characteristics of Ag-incorporated bioactive glasses prepared by a modified sol–gel method with a shortened synthesis time and without the use of catalysts |
title_full_unstemmed | Characteristics of Ag-incorporated bioactive glasses prepared by a modified sol–gel method with a shortened synthesis time and without the use of catalysts |
title_short | Characteristics of Ag-incorporated bioactive glasses prepared by a modified sol–gel method with a shortened synthesis time and without the use of catalysts |
title_sort | characteristics of ag-incorporated bioactive glasses prepared by a modified sol–gel method with a shortened synthesis time and without the use of catalysts |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590098/ https://www.ncbi.nlm.nih.gov/pubmed/36329943 http://dx.doi.org/10.1039/d2ra05671b |
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