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SOT101 induces NK cell cytotoxicity and potentiates antibody-dependent cell cytotoxicity and anti-tumor activity

SOT101 is a superagonist fusion protein of interleukin (IL)-15 and the IL-15 receptor α (IL-15Rα) sushi+ domain, representing a promising clinical candidate for the treatment of cancer. SOT101 among other immune cells specifically stimulates natural killer (NK) cells and memory CD8(+) T cells with n...

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Detalles Bibliográficos
Autores principales:	Antosova, Zuzana, Podzimkova, Nada, Tomala, Jakub, Augustynkova, Katerina, Sajnerova, Katerina, Nedvedova, Eva, Sirova, Milada, de Martynoff, Guy, Bechard, David, Moebius, Ulrich, Kovar, Marek, Spisek, Radek, Adkins, Irena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590108/ https://www.ncbi.nlm.nih.gov/pubmed/36300122 http://dx.doi.org/10.3389/fimmu.2022.989895

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