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Evaluation of the effect of gentamicin in surgical perfusion solution on cataract postoperative endophthalmitis

OBJECTIVE: To evaluate the effect of gentamicin in surgical perfusion solution on endophthalmitis incidence after cataract surgery. METHODS: A retrospective analysis of endophthalmitis incidence was conducted in two groups of patients who underwent cataract surgery, with (Group B) or without gentami...

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Autores principales: Ma, Wenjiang, Hou, Guanghua, Wang, Junfang, Liu, Ting, Tian, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590137/
https://www.ncbi.nlm.nih.gov/pubmed/36274140
http://dx.doi.org/10.1186/s12886-022-02633-2
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author Ma, Wenjiang
Hou, Guanghua
Wang, Junfang
Liu, Ting
Tian, Fang
author_facet Ma, Wenjiang
Hou, Guanghua
Wang, Junfang
Liu, Ting
Tian, Fang
author_sort Ma, Wenjiang
collection PubMed
description OBJECTIVE: To evaluate the effect of gentamicin in surgical perfusion solution on endophthalmitis incidence after cataract surgery. METHODS: A retrospective analysis of endophthalmitis incidence was conducted in two groups of patients who underwent cataract surgery, with (Group B) or without gentamicin (Group A) in the surgical perfusion solution. Endophthalmitis incidence, the isolated pathogenic bacteria strains and their antibiotic sensitivity, and the drug-resistant genotype of the pathogens were examined. RESULTS: The incidence of endophthalmitis in patients of group A was 0.8‰. Thirteen pathogenic bacterial strains were isolated from the patient samples in group A, including 8 strains of Staphylococcus epidermidis, 1 Staphylococcus aureus, 1 Streptococcus pneumoniae, 1 Streptococcus bovis, 1 Enterococcus faecium and 1 Morganella sp. The incidence of endophthalmitis in group B patients was 0.2‰, which was significantly lower than that in group A (P<0.05). Five strains of pathogenic bacteria were successfully isolated, including 2 strains of Enterococcus faecium, 1 Enterococcus faecalis, 1 Staphylococcus epidermidis and 1 Staphylococcus aureus. There was no significant difference in the proportion of Staphylococcus strains in all isolated bacteria between the two groups (P > 0.05). However, the proportion of Enterococci isolated in group B samples was higher than that in group A (P < 0.05). There were more gentamicin-sensitive strains than levofloxacin-sensitive strains identified (P < 0.05). Interestingly, aminoglycoside-inactivating enzyme resistance gene was detected in Enterococcus strains. CONCLUSION: Our data suggest that gentamicin-containing perfusion solution can reduce the incidence of postoperative endophthalmitis in cataract patients. However, the selective pressure imposed by gentamicin may facilitate the development of aminoglycoside-resistant Enterococcos strains.
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spelling pubmed-95901372022-10-25 Evaluation of the effect of gentamicin in surgical perfusion solution on cataract postoperative endophthalmitis Ma, Wenjiang Hou, Guanghua Wang, Junfang Liu, Ting Tian, Fang BMC Ophthalmol Research OBJECTIVE: To evaluate the effect of gentamicin in surgical perfusion solution on endophthalmitis incidence after cataract surgery. METHODS: A retrospective analysis of endophthalmitis incidence was conducted in two groups of patients who underwent cataract surgery, with (Group B) or without gentamicin (Group A) in the surgical perfusion solution. Endophthalmitis incidence, the isolated pathogenic bacteria strains and their antibiotic sensitivity, and the drug-resistant genotype of the pathogens were examined. RESULTS: The incidence of endophthalmitis in patients of group A was 0.8‰. Thirteen pathogenic bacterial strains were isolated from the patient samples in group A, including 8 strains of Staphylococcus epidermidis, 1 Staphylococcus aureus, 1 Streptococcus pneumoniae, 1 Streptococcus bovis, 1 Enterococcus faecium and 1 Morganella sp. The incidence of endophthalmitis in group B patients was 0.2‰, which was significantly lower than that in group A (P<0.05). Five strains of pathogenic bacteria were successfully isolated, including 2 strains of Enterococcus faecium, 1 Enterococcus faecalis, 1 Staphylococcus epidermidis and 1 Staphylococcus aureus. There was no significant difference in the proportion of Staphylococcus strains in all isolated bacteria between the two groups (P > 0.05). However, the proportion of Enterococci isolated in group B samples was higher than that in group A (P < 0.05). There were more gentamicin-sensitive strains than levofloxacin-sensitive strains identified (P < 0.05). Interestingly, aminoglycoside-inactivating enzyme resistance gene was detected in Enterococcus strains. CONCLUSION: Our data suggest that gentamicin-containing perfusion solution can reduce the incidence of postoperative endophthalmitis in cataract patients. However, the selective pressure imposed by gentamicin may facilitate the development of aminoglycoside-resistant Enterococcos strains. BioMed Central 2022-10-23 /pmc/articles/PMC9590137/ /pubmed/36274140 http://dx.doi.org/10.1186/s12886-022-02633-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Ma, Wenjiang
Hou, Guanghua
Wang, Junfang
Liu, Ting
Tian, Fang
Evaluation of the effect of gentamicin in surgical perfusion solution on cataract postoperative endophthalmitis
title Evaluation of the effect of gentamicin in surgical perfusion solution on cataract postoperative endophthalmitis
title_full Evaluation of the effect of gentamicin in surgical perfusion solution on cataract postoperative endophthalmitis
title_fullStr Evaluation of the effect of gentamicin in surgical perfusion solution on cataract postoperative endophthalmitis
title_full_unstemmed Evaluation of the effect of gentamicin in surgical perfusion solution on cataract postoperative endophthalmitis
title_short Evaluation of the effect of gentamicin in surgical perfusion solution on cataract postoperative endophthalmitis
title_sort evaluation of the effect of gentamicin in surgical perfusion solution on cataract postoperative endophthalmitis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590137/
https://www.ncbi.nlm.nih.gov/pubmed/36274140
http://dx.doi.org/10.1186/s12886-022-02633-2
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