Cargando…

Reversal of cancer gene expression identifies repurposed drugs for diffuse intrinsic pontine glioma

Diffuse intrinsic pontine glioma (DIPG) is an aggressive incurable brainstem tumor that targets young children. Complete resection is not possible, and chemotherapy and radiotherapy are currently only palliative. This study aimed to identify potential therapeutic agents using a computational pipelin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Guisheng, Newbury, Patrick, Ishi, Yukitomo, Chekalin, Eugene, Zeng, Billy, Glicksberg, Benjamin S., Wen, Anita, Paithankar, Shreya, Sasaki, Takahiro, Suri, Amreena, Nazarian, Javad, Pacold, Michael E., Brat, Daniel J., Nicolaides, Theodore, Chen, Bin, Hashizume, Rintaro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590174/ https://www.ncbi.nlm.nih.gov/pubmed/36274161 http://dx.doi.org/10.1186/s40478-022-01463-z

Ejemplares similares

DIPG-18. AI HUNTING FOR NEW DRUGS IN PEDIATRIC GLIOMA
por: Hashizume, Rintaro, et al.
Publicado: (2023)

Epigenetic Targeted Therapy for Diffuse Intrinsic Pontine Glioma
por: HASHIZUME, Rintaro
Publicado: (2017)

Patient-derived Tumor Models for Diffuse Intrinsic Pontine Gliomas
por: Hashizume, Rintaro, et al.
Publicado: (2017)

DIPG-24. BRD4 INHIBITION AS A RADIOSENSITIZER THROUGH BLOCKING DNA REPAIR FOR THE TREATMENT OF DIFFUSE MIDLINE GLIOMA
por: Watanabe, Jun, et al.
Publicado: (2023)

DDEL-11. CONVECTION-ENHANCED DELIVERY OF EZH2 INHIBITOR FOR THE TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMA
por: Sasaki, Takahiro, et al.
Publicado: (2020)

ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis
por: Hoeman, Christine M., et al.
Publicado: (2019)

REST upregulates gremlin to modulate diffuse intrinsic pontine glioma vasculature
por: Shaik, Shavali, et al.
Publicado: (2017)

Differential Expression of Wilms’ Tumor Protein in Diffuse Intrinsic Pontine Glioma
por: Lee, Sulgi, et al.
Publicado: (2019)

Analysis of Infected Host Gene Expression Reveals Repurposed Drug Candidates and Time-Dependent Host Response Dynamics for COVID-19
por: Xing, Jing, et al.
Publicado: (2020)

BGLM: big data-guided LOINC mapping with multi-language support
por: Liu, Ke, et al.
Publicado: (2022)

Repurposing the anti-epileptic drug sodium valproate as an adjuvant treatment for diffuse intrinsic pontine glioma
por: Killick-Cole, Clare L., et al.
Publicado: (2017)

Repurposing Vandetanib plus Everolimus for the Treatment of ACVR1-Mutant Diffuse Intrinsic Pontine Glioma
por: Carvalho, Diana M., et al.
Publicado: (2022)

The emerging role of NG2 in pediatric diffuse intrinsic pontine glioma
por: Yadavilli, Sridevi, et al.
Publicado: (2015)

Measuring Tumor Metabolism in Pediatric Diffuse Intrinsic Pontine Glioma Using Hyperpolarized Carbon-13 MR Metabolic Imaging
por: Autry, Adam W., et al.
Publicado: (2018)

DIPG-03. THERAPEUTIC TARGETING OF TRANSCRIPTIONAL ELONGATION IN DIFFUSE INTRINSIC PONTINE GLIOMA
por: Katagi, Hiroaki, et al.
Publicado: (2020)

DIPG-51. ACVR1 MUTATIONS PROMOTE TUMOR GROWTH IN MODELS OF DIFFUSE INTRINSIC PONTINE GLIOMA
por: Adorno, Jennifer Ocasio, et al.
Publicado: (2020)

DIPG-44. A GAIN OF FUNCTION Ezh2 MUTATION DELAYS DIFFUSE INTRINSIC PONTINE GLIOMA PROGRESSION
por: Dhar, Swati, et al.
Publicado: (2020)

Metastatic Diffuse Intrinsic Pontine Glioma to the Peritoneal Cavity Via Ventriculoperitoneal Shunt: Case Report and Literature Review
por: Barajas, Ramon Francisco, et al.
Publicado: (2015)

Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma
por: Nikbakht, Hamid, et al.
Publicado: (2016)

Evaluating cell lines as models for metastatic breast cancer through integrative analysis of genomic data
por: Liu, Ke, et al.
Publicado: (2019)

Histological and molecular analysis of a progressive diffuse intrinsic pontine glioma and synchronous metastatic lesions: a case report
por: Nazarian, Javad, et al.
Publicado: (2016)

Increased 5-hydroxymethylcytosine and decreased 5-methylcytosine are indicators of global epigenetic dysregulation in diffuse intrinsic pontine glioma
por: Ahsan, Sama, et al.
Publicado: (2014)

DIPG-13. TARGETING HYPOXIA AND MITOCHONDRIA WITH REPURPOSED METABOLIC DRUGS AS AN APPROACH TO RADIOSENSITIZATION FOR DIFFUSE INTRINSIC PONTINE GLIOMAS (DIPG)
por: Shen, Han, et al.
Publicado: (2020)

A novel mouse model of diffuse midline glioma initiated in neonatal oligodendrocyte progenitor cells highlights cell‐of‐origin dependent effects of H3K27M
por: Tomita, Yusuke, et al.
Publicado: (2022)

Addendum: Histological and molecular analysis of a progressive diffuse intrinsic pontine glioma and synchronous metastatic lesions: a case report
por: Nazarian, Javad, et al.
Publicado: (2023)

Diffuse intrinsic pontine glioma: poised for progress
por: Warren, Katherine E.
Publicado: (2012)

Nanotechnology Applications for Diffuse Intrinsic Pontine Glioma
por: Bredlau, Amy Lee, et al.
Publicado: (2017)

Genomic Insights into Diffuse Intrinsic Pontine Glioma
por: Lapin, Danielle H., et al.
Publicado: (2017)

HGG-04. TARGETING GABAERGIC NEURON-GLIOMA SYNAPSES IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) THROUGH ANTI-EPILEPTIC DRUG REPURPOSING
por: Barron, Tara, et al.
Publicado: (2021)

Pre-Clinical Models of Diffuse Intrinsic Pontine Glioma
por: Misuraca, Katherine L., et al.
Publicado: (2015)

Hypofractionated radiotherapy in children with diffuse intrinsic pontine glioma
por: Hayashi, Akiko, et al.
Publicado: (2020)

Immune Microenvironment and Immunotherapies for Diffuse Intrinsic Pontine Glioma
por: Chen, Yujia, et al.
Publicado: (2023)

Radiotherapy for Diffuse Intrinsic Pontine Glioma: Insufficient but Indispensable
por: Kim, Hyun Ju, et al.
Publicado: (2023)

Epigenetic and Metabolic Changes in Diffuse Intrinsic Pontine Glioma
por: Park, Jiyoon, et al.
Publicado: (2023)

Inhibition of polo-like kinase 4 (PLK4): a new therapeutic option for rhabdoid tumors and pediatric medulloblastoma
por: Sredni, Simone Treiger, et al.
Publicado: (2017)

Targeted therapy for pediatric diffuse intrinsic pontine glioma: a single-center experience
por: Del Baldo, Giada, et al.
Publicado: (2022)

Pathology, Molecular Genetics, and Epigenetics of Diffuse Intrinsic Pontine Glioma
por: Buczkowicz, Pawel, et al.
Publicado: (2015)

Bioinformatics analysis of the molecular mechanism of diffuse intrinsic pontine glioma
por: Deng, Lei, et al.
Publicado: (2016)

Non-inflammatory tumor microenvironment of diffuse intrinsic pontine glioma
por: Lin, Grant L., et al.
Publicado: (2018)

Deceptive morphologic and epigenetic heterogeneity in diffuse intrinsic pontine glioma
por: Bugiani, Marianna, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_dsadafku7req9tdro8nturhfpq