Cargando…

Hypoxic-induced resting ventilatory and circulatory responses under multistep hypoxia is related to decline in peak aerobic capacity in hypoxia

BACKGROUND: Several factors have been shown to contribute to hypoxic-induced declined in aerobic capacity. In the present study, we investigated the effects of resting hypoxic ventilatory and cardiac responses (HVR and HCR) on hypoxic-induced declines in peak oxygen uptake ([Formula: see text] O(2pe...

Descripción completa

Detalles Bibliográficos
Autores principales: Horiuchi, Masahiro, Dobashi, Shohei, Kiuchi, Masataka, Fukuoka, Yoshiyuki, Koyama, Katsuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590180/
https://www.ncbi.nlm.nih.gov/pubmed/36280884
http://dx.doi.org/10.1186/s40101-022-00310-3
_version_ 1784814458872266752
author Horiuchi, Masahiro
Dobashi, Shohei
Kiuchi, Masataka
Fukuoka, Yoshiyuki
Koyama, Katsuhiro
author_facet Horiuchi, Masahiro
Dobashi, Shohei
Kiuchi, Masataka
Fukuoka, Yoshiyuki
Koyama, Katsuhiro
author_sort Horiuchi, Masahiro
collection PubMed
description BACKGROUND: Several factors have been shown to contribute to hypoxic-induced declined in aerobic capacity. In the present study, we investigated the effects of resting hypoxic ventilatory and cardiac responses (HVR and HCR) on hypoxic-induced declines in peak oxygen uptake ([Formula: see text] O(2peak)). METHODS: Peak oxygen uptakes was measured in normobaric normoxia (room air) and hypoxia (14.1% O(2)) for 10 young healthy men. The resting HVR and HCR were evaluated at multiple steps of hypoxia (1 h at each of 21, 18, 15 and 12% O(2)). Arterial desaturation (ΔSaO(2)) was calculate by the difference between SaO(2) at normoxia—at each level of hypoxia (%). HVR was calculate by differences in pulmonary ventilation between normoxia and each level of hypoxia against ΔSaO(2) (L min(−1) %(−1) kg(−1)). Similarly, HCR was calculated by differences in heart rate between normoxia and each level of hypoxia against ΔSaO(2) (beats min(−1) %(−1)). RESULTS: [Formula: see text] O(2peak) significantly decreased in hypoxia by 21% on average (P < 0.001). HVR was not associated with changes in [Formula: see text] O(2peak). ΔSaO(2) from normoxia to 18% or 15% O(2) and HCR between normoxia and 12% O(2) were associated with changes in [Formula: see text] O(2peak) (P < 0.05, respectively). The most optimal model using multiple linear regression analysis found that ΔHCR at 12% O(2) and ΔSaO(2) at 15% O(2) were explanatory variables (adjusted R(2) = 0.580, P = 0.02). CONCLUSION: These results suggest that arterial desaturation at moderate hypoxia and heart rate responses at severe hypoxia may account for hypoxic-induced declines in peak aerobic capacity, but ventilatory responses may be unrelated.
format Online
Article
Text
id pubmed-9590180
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-95901802022-10-25 Hypoxic-induced resting ventilatory and circulatory responses under multistep hypoxia is related to decline in peak aerobic capacity in hypoxia Horiuchi, Masahiro Dobashi, Shohei Kiuchi, Masataka Fukuoka, Yoshiyuki Koyama, Katsuhiro J Physiol Anthropol Original Article BACKGROUND: Several factors have been shown to contribute to hypoxic-induced declined in aerobic capacity. In the present study, we investigated the effects of resting hypoxic ventilatory and cardiac responses (HVR and HCR) on hypoxic-induced declines in peak oxygen uptake ([Formula: see text] O(2peak)). METHODS: Peak oxygen uptakes was measured in normobaric normoxia (room air) and hypoxia (14.1% O(2)) for 10 young healthy men. The resting HVR and HCR were evaluated at multiple steps of hypoxia (1 h at each of 21, 18, 15 and 12% O(2)). Arterial desaturation (ΔSaO(2)) was calculate by the difference between SaO(2) at normoxia—at each level of hypoxia (%). HVR was calculate by differences in pulmonary ventilation between normoxia and each level of hypoxia against ΔSaO(2) (L min(−1) %(−1) kg(−1)). Similarly, HCR was calculated by differences in heart rate between normoxia and each level of hypoxia against ΔSaO(2) (beats min(−1) %(−1)). RESULTS: [Formula: see text] O(2peak) significantly decreased in hypoxia by 21% on average (P < 0.001). HVR was not associated with changes in [Formula: see text] O(2peak). ΔSaO(2) from normoxia to 18% or 15% O(2) and HCR between normoxia and 12% O(2) were associated with changes in [Formula: see text] O(2peak) (P < 0.05, respectively). The most optimal model using multiple linear regression analysis found that ΔHCR at 12% O(2) and ΔSaO(2) at 15% O(2) were explanatory variables (adjusted R(2) = 0.580, P = 0.02). CONCLUSION: These results suggest that arterial desaturation at moderate hypoxia and heart rate responses at severe hypoxia may account for hypoxic-induced declines in peak aerobic capacity, but ventilatory responses may be unrelated. BioMed Central 2022-10-24 /pmc/articles/PMC9590180/ /pubmed/36280884 http://dx.doi.org/10.1186/s40101-022-00310-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Original Article
Horiuchi, Masahiro
Dobashi, Shohei
Kiuchi, Masataka
Fukuoka, Yoshiyuki
Koyama, Katsuhiro
Hypoxic-induced resting ventilatory and circulatory responses under multistep hypoxia is related to decline in peak aerobic capacity in hypoxia
title Hypoxic-induced resting ventilatory and circulatory responses under multistep hypoxia is related to decline in peak aerobic capacity in hypoxia
title_full Hypoxic-induced resting ventilatory and circulatory responses under multistep hypoxia is related to decline in peak aerobic capacity in hypoxia
title_fullStr Hypoxic-induced resting ventilatory and circulatory responses under multistep hypoxia is related to decline in peak aerobic capacity in hypoxia
title_full_unstemmed Hypoxic-induced resting ventilatory and circulatory responses under multistep hypoxia is related to decline in peak aerobic capacity in hypoxia
title_short Hypoxic-induced resting ventilatory and circulatory responses under multistep hypoxia is related to decline in peak aerobic capacity in hypoxia
title_sort hypoxic-induced resting ventilatory and circulatory responses under multistep hypoxia is related to decline in peak aerobic capacity in hypoxia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590180/
https://www.ncbi.nlm.nih.gov/pubmed/36280884
http://dx.doi.org/10.1186/s40101-022-00310-3
work_keys_str_mv AT horiuchimasahiro hypoxicinducedrestingventilatoryandcirculatoryresponsesundermultistephypoxiaisrelatedtodeclineinpeakaerobiccapacityinhypoxia
AT dobashishohei hypoxicinducedrestingventilatoryandcirculatoryresponsesundermultistephypoxiaisrelatedtodeclineinpeakaerobiccapacityinhypoxia
AT kiuchimasataka hypoxicinducedrestingventilatoryandcirculatoryresponsesundermultistephypoxiaisrelatedtodeclineinpeakaerobiccapacityinhypoxia
AT fukuokayoshiyuki hypoxicinducedrestingventilatoryandcirculatoryresponsesundermultistephypoxiaisrelatedtodeclineinpeakaerobiccapacityinhypoxia
AT koyamakatsuhiro hypoxicinducedrestingventilatoryandcirculatoryresponsesundermultistephypoxiaisrelatedtodeclineinpeakaerobiccapacityinhypoxia