Ivabradine toxicity: a case report

BACKGROUND: We describe a case of symptomatic bradycardia resulting from ivabradine toxicity by measurement of ivabradine levels, of which there are limited reports in the literature. CASE PRESENTATION: A 43-year-old White female presented with several days of near syncope and dizziness accompanied...

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Detalles Bibliográficos
Autores principales: Singh, Kavisha, Alagarraju, Muthukumar R., Wolf, Carl E., Poklis, Justin L., Kulkarni, Nitin, Tharpe, William, Joshi, Parag H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590231/
https://www.ncbi.nlm.nih.gov/pubmed/36274174
http://dx.doi.org/10.1186/s13256-022-03554-w
Descripción
Sumario:BACKGROUND: We describe a case of symptomatic bradycardia resulting from ivabradine toxicity by measurement of ivabradine levels, of which there are limited reports in the literature. CASE PRESENTATION: A 43-year-old White female presented with several days of near syncope and dizziness accompanied by a drop in her heart rate to 50 beats per minute. She was taking ivabradine for inappropriate sinus tachycardia. After excluding several other causes of bradycardia, we made the diagnosis of ivabradine toxicity by measurement of serum ivabradine levels, an approach that is currently not clinically available. CONCLUSIONS: Measurement of serum ivabradine levels and knowledge of the pharmacokinetic properties of the drug can be utilized to confirm the diagnosis of ivabradine toxicity. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13256-022-03554-w.

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