Ivabradine toxicity: a case report

BACKGROUND: We describe a case of symptomatic bradycardia resulting from ivabradine toxicity by measurement of ivabradine levels, of which there are limited reports in the literature. CASE PRESENTATION: A 43-year-old White female presented with several days of near syncope and dizziness accompanied...

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Autores principales: Singh, Kavisha, Alagarraju, Muthukumar R., Wolf, Carl E., Poklis, Justin L., Kulkarni, Nitin, Tharpe, William, Joshi, Parag H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590231/
https://www.ncbi.nlm.nih.gov/pubmed/36274174
http://dx.doi.org/10.1186/s13256-022-03554-w
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author Singh, Kavisha
Alagarraju, Muthukumar R.
Wolf, Carl E.
Poklis, Justin L.
Kulkarni, Nitin
Tharpe, William
Joshi, Parag H.
author_facet Singh, Kavisha
Alagarraju, Muthukumar R.
Wolf, Carl E.
Poklis, Justin L.
Kulkarni, Nitin
Tharpe, William
Joshi, Parag H.
author_sort Singh, Kavisha
collection PubMed
description BACKGROUND: We describe a case of symptomatic bradycardia resulting from ivabradine toxicity by measurement of ivabradine levels, of which there are limited reports in the literature. CASE PRESENTATION: A 43-year-old White female presented with several days of near syncope and dizziness accompanied by a drop in her heart rate to 50 beats per minute. She was taking ivabradine for inappropriate sinus tachycardia. After excluding several other causes of bradycardia, we made the diagnosis of ivabradine toxicity by measurement of serum ivabradine levels, an approach that is currently not clinically available. CONCLUSIONS: Measurement of serum ivabradine levels and knowledge of the pharmacokinetic properties of the drug can be utilized to confirm the diagnosis of ivabradine toxicity. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13256-022-03554-w.
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spelling pubmed-95902312022-10-25 Ivabradine toxicity: a case report Singh, Kavisha Alagarraju, Muthukumar R. Wolf, Carl E. Poklis, Justin L. Kulkarni, Nitin Tharpe, William Joshi, Parag H. J Med Case Rep Case Report BACKGROUND: We describe a case of symptomatic bradycardia resulting from ivabradine toxicity by measurement of ivabradine levels, of which there are limited reports in the literature. CASE PRESENTATION: A 43-year-old White female presented with several days of near syncope and dizziness accompanied by a drop in her heart rate to 50 beats per minute. She was taking ivabradine for inappropriate sinus tachycardia. After excluding several other causes of bradycardia, we made the diagnosis of ivabradine toxicity by measurement of serum ivabradine levels, an approach that is currently not clinically available. CONCLUSIONS: Measurement of serum ivabradine levels and knowledge of the pharmacokinetic properties of the drug can be utilized to confirm the diagnosis of ivabradine toxicity. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13256-022-03554-w. BioMed Central 2022-10-24 /pmc/articles/PMC9590231/ /pubmed/36274174 http://dx.doi.org/10.1186/s13256-022-03554-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Singh, Kavisha
Alagarraju, Muthukumar R.
Wolf, Carl E.
Poklis, Justin L.
Kulkarni, Nitin
Tharpe, William
Joshi, Parag H.
Ivabradine toxicity: a case report
title Ivabradine toxicity: a case report
title_full Ivabradine toxicity: a case report
title_fullStr Ivabradine toxicity: a case report
title_full_unstemmed Ivabradine toxicity: a case report
title_short Ivabradine toxicity: a case report
title_sort ivabradine toxicity: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590231/
https://www.ncbi.nlm.nih.gov/pubmed/36274174
http://dx.doi.org/10.1186/s13256-022-03554-w
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AT kulkarninitin ivabradinetoxicityacasereport
AT tharpewilliam ivabradinetoxicityacasereport
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