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Discovery and multi-parametric optimization of a high-affinity antibody against interleukin-25 with neutralizing activity in a mouse model of skin inflammation

BACKGROUND: Interleukin (IL)25 has been implicated in tissue homeostasis at barrier surfaces and the initiation of type two inflammatory signaling in response to infection and cell injury across multiple organs. We sought to discover and engineer a high affinity neutralizing antibody and evaluate th...

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Detalles Bibliográficos
Autores principales:	Bone, Ruth, Fennell, Brian J, Tam, Amy, Sheldon, Richard, Nocka, Karl, Varghese, Sreeja, Chang, Chew Shun, Hawerkamp, Heike C, Yeow, Aoife, Saunders, Sean P, Hams, Emily, Walsh, Patrick T, Cunningham, Orla, Fallon, Padraic G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590316/ https://www.ncbi.nlm.nih.gov/pubmed/36299415 http://dx.doi.org/10.1093/abt/tbac022

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