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Clinical Outcomes of Delayed Osteoarticular Tuberculosis: A Review of 30 Cases

PURPOSE: The lack of knowledge regarding osteoarticular tuberculosis (TB) cases in Indonesia leads to delayed and chronic conditions. This study aims to evaluate clinical outcomes of patients with osteoarticular TB. MATERIALS AND METHODS: Thirty osteoarticular cases were retrospectively analyzed, wi...

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Autores principales: Kamal, Achmad Fauzi, Oktari, Prima Rizky, Kurniawan, Aryadi, Kodrat, Evelina, Mumpuni, Nadia Asmirtania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590347/
https://www.ncbi.nlm.nih.gov/pubmed/36299465
http://dx.doi.org/10.2147/ORR.S366294
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author Kamal, Achmad Fauzi
Oktari, Prima Rizky
Kurniawan, Aryadi
Kodrat, Evelina
Mumpuni, Nadia Asmirtania
author_facet Kamal, Achmad Fauzi
Oktari, Prima Rizky
Kurniawan, Aryadi
Kodrat, Evelina
Mumpuni, Nadia Asmirtania
author_sort Kamal, Achmad Fauzi
collection PubMed
description PURPOSE: The lack of knowledge regarding osteoarticular tuberculosis (TB) cases in Indonesia leads to delayed and chronic conditions. This study aims to evaluate clinical outcomes of patients with osteoarticular TB. MATERIALS AND METHODS: Thirty osteoarticular cases were retrospectively analyzed, with a focus on non-immunocompromised patients without spine involvement. Chemotherapy length, operative treatment method, and infection recurrence were evaluated. RESULTS: The majority (60%) of patients were aged between 19 to 49 years. The most common complaint was painful swelling, particularly during physical activity. Weight-bearing joints, such as the hips, knees, and ankles, were the most affected. Laboratory results showed over half of the patients had anemia, 96% had elevated erythrocyte sedimentation rate (ESR), and 76% had elevated C-reactive protein (CRP) levels. Radiological findings varied, with lytic lesions, abscesses, and joint destruction observed. All patients presented with pathognomonic histological tubercle appearances, with caseous necrosis, lymphocytes, and Langhans giant cells present. Twenty-nine cases were treated with anti-TB drugs for 12 months, while one recurrent case received the drugs for 24 months. All patients underwent surgery to gain local infection control. CONCLUSION: Osteoarticular TB is a common manifestation of extrapulmonary TB and must not be overlooked. Early detection of osteoarticular TB may prevent limb morbidity. Although anti-TB drugs are the primary treatment for osteoarticular TB, in some cases, surgery is required to establish a diagnosis and gain local infection control.
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spelling pubmed-95903472022-10-25 Clinical Outcomes of Delayed Osteoarticular Tuberculosis: A Review of 30 Cases Kamal, Achmad Fauzi Oktari, Prima Rizky Kurniawan, Aryadi Kodrat, Evelina Mumpuni, Nadia Asmirtania Orthop Res Rev Case Series PURPOSE: The lack of knowledge regarding osteoarticular tuberculosis (TB) cases in Indonesia leads to delayed and chronic conditions. This study aims to evaluate clinical outcomes of patients with osteoarticular TB. MATERIALS AND METHODS: Thirty osteoarticular cases were retrospectively analyzed, with a focus on non-immunocompromised patients without spine involvement. Chemotherapy length, operative treatment method, and infection recurrence were evaluated. RESULTS: The majority (60%) of patients were aged between 19 to 49 years. The most common complaint was painful swelling, particularly during physical activity. Weight-bearing joints, such as the hips, knees, and ankles, were the most affected. Laboratory results showed over half of the patients had anemia, 96% had elevated erythrocyte sedimentation rate (ESR), and 76% had elevated C-reactive protein (CRP) levels. Radiological findings varied, with lytic lesions, abscesses, and joint destruction observed. All patients presented with pathognomonic histological tubercle appearances, with caseous necrosis, lymphocytes, and Langhans giant cells present. Twenty-nine cases were treated with anti-TB drugs for 12 months, while one recurrent case received the drugs for 24 months. All patients underwent surgery to gain local infection control. CONCLUSION: Osteoarticular TB is a common manifestation of extrapulmonary TB and must not be overlooked. Early detection of osteoarticular TB may prevent limb morbidity. Although anti-TB drugs are the primary treatment for osteoarticular TB, in some cases, surgery is required to establish a diagnosis and gain local infection control. Dove 2022-10-20 /pmc/articles/PMC9590347/ /pubmed/36299465 http://dx.doi.org/10.2147/ORR.S366294 Text en © 2022 Kamal et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Case Series
Kamal, Achmad Fauzi
Oktari, Prima Rizky
Kurniawan, Aryadi
Kodrat, Evelina
Mumpuni, Nadia Asmirtania
Clinical Outcomes of Delayed Osteoarticular Tuberculosis: A Review of 30 Cases
title Clinical Outcomes of Delayed Osteoarticular Tuberculosis: A Review of 30 Cases
title_full Clinical Outcomes of Delayed Osteoarticular Tuberculosis: A Review of 30 Cases
title_fullStr Clinical Outcomes of Delayed Osteoarticular Tuberculosis: A Review of 30 Cases
title_full_unstemmed Clinical Outcomes of Delayed Osteoarticular Tuberculosis: A Review of 30 Cases
title_short Clinical Outcomes of Delayed Osteoarticular Tuberculosis: A Review of 30 Cases
title_sort clinical outcomes of delayed osteoarticular tuberculosis: a review of 30 cases
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590347/
https://www.ncbi.nlm.nih.gov/pubmed/36299465
http://dx.doi.org/10.2147/ORR.S366294
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