Biocompatibility Studies on a Collagen-Hydroxyapatite Biomaterial

The current treatment of osteomyelitis includes systemic antibiotic therapy and a debridement procedure of the formed biofilm and necrotic tissue. Moreover, cements and three-dimensional scaffolds are used both for the delivery of therapeutic agents and as fillers for bone defects. The aim of our re...

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Autores principales: FILIP IONESCU, OANA-LILIANA, MOCANU, ANDREEA GABRIELA, NEACŞU, IONELA ANDREEA, CIOCÎLTEU, MARIA-VIORICA, RĂU, GABRIELA, NEAMŢU, JOHNY
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical University Publishing House Craiova 2022
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590366/
https://www.ncbi.nlm.nih.gov/pubmed/36320879
http://dx.doi.org/10.12865/CHSJ.48.02.12
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author FILIP IONESCU, OANA-LILIANA
MOCANU, ANDREEA GABRIELA
NEACŞU, IONELA ANDREEA
CIOCÎLTEU, MARIA-VIORICA
RĂU, GABRIELA
NEAMŢU, JOHNY
author_facet FILIP IONESCU, OANA-LILIANA
MOCANU, ANDREEA GABRIELA
NEACŞU, IONELA ANDREEA
CIOCÎLTEU, MARIA-VIORICA
RĂU, GABRIELA
NEAMŢU, JOHNY
author_sort FILIP IONESCU, OANA-LILIANA
collection PubMed
description The current treatment of osteomyelitis includes systemic antibiotic therapy and a debridement procedure of the formed biofilm and necrotic tissue. Moreover, cements and three-dimensional scaffolds are used both for the delivery of therapeutic agents and as fillers for bone defects. The aim of our research was to test, on cellular cultures, the biocompatibility of a previously synthesized microporous biocomposite containing hydroxyapatite and a collagen matrix including a therapeutic agent (ciprofloxacin and gentamicin). The scaffold was obtained by direct mineralization namely co-precipitation of hydroxyapatite on a collagen matrix.
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spelling pubmed-95903662022-10-31 Biocompatibility Studies on a Collagen-Hydroxyapatite Biomaterial FILIP IONESCU, OANA-LILIANA MOCANU, ANDREEA GABRIELA NEACŞU, IONELA ANDREEA CIOCÎLTEU, MARIA-VIORICA RĂU, GABRIELA NEAMŢU, JOHNY Curr Health Sci J Original Paper The current treatment of osteomyelitis includes systemic antibiotic therapy and a debridement procedure of the formed biofilm and necrotic tissue. Moreover, cements and three-dimensional scaffolds are used both for the delivery of therapeutic agents and as fillers for bone defects. The aim of our research was to test, on cellular cultures, the biocompatibility of a previously synthesized microporous biocomposite containing hydroxyapatite and a collagen matrix including a therapeutic agent (ciprofloxacin and gentamicin). The scaffold was obtained by direct mineralization namely co-precipitation of hydroxyapatite on a collagen matrix. Medical University Publishing House Craiova 2022 2022-06-30 /pmc/articles/PMC9590366/ /pubmed/36320879 http://dx.doi.org/10.12865/CHSJ.48.02.12 Text en Copyright © 2014, Medical University Publishing House Craiova https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.
spellingShingle Original Paper
FILIP IONESCU, OANA-LILIANA
MOCANU, ANDREEA GABRIELA
NEACŞU, IONELA ANDREEA
CIOCÎLTEU, MARIA-VIORICA
RĂU, GABRIELA
NEAMŢU, JOHNY
Biocompatibility Studies on a Collagen-Hydroxyapatite Biomaterial
title Biocompatibility Studies on a Collagen-Hydroxyapatite Biomaterial
title_full Biocompatibility Studies on a Collagen-Hydroxyapatite Biomaterial
title_fullStr Biocompatibility Studies on a Collagen-Hydroxyapatite Biomaterial
title_full_unstemmed Biocompatibility Studies on a Collagen-Hydroxyapatite Biomaterial
title_short Biocompatibility Studies on a Collagen-Hydroxyapatite Biomaterial
title_sort biocompatibility studies on a collagen-hydroxyapatite biomaterial
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590366/
https://www.ncbi.nlm.nih.gov/pubmed/36320879
http://dx.doi.org/10.12865/CHSJ.48.02.12
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