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Signal strength of STING activation determines cytokine plasticity and cell death in human monocytes

The cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) pathway is a cytosolic sensor of microbial and host-derived DNA and plays a key role in innate immunity. Activation of STING by cyclic dinucleotide (CDN) ligands in human monocytes induces a type I interferon response and prod...

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Detalles Bibliográficos
Autores principales:	Kabelitz, Dieter, Zarobkiewicz, Michal, Heib, Michelle, Serrano, Ruben, Kunz, Monika, Chitadze, Guranda, Adam, Dieter, Peters, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590392/ https://www.ncbi.nlm.nih.gov/pubmed/36280676 http://dx.doi.org/10.1038/s41598-022-20519-7

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