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The role of insufficient sleep and circadian misalignment in obesity

Traditional risk factors for obesity and the metabolic syndrome, such as excess energy intake and lack of physical activity, cannot fully explain the high prevalence of these conditions. Insufficient sleep and circadian misalignment predispose individuals to poor metabolic health and promote weight...

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Autores principales: Chaput, Jean-Philippe, McHill, Andrew W., Cox, Rebecca C., Broussard, Josiane L., Dutil, Caroline, da Costa, Bruno G. G., Sampasa-Kanyinga, Hugues, Wright, Kenneth P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590398/
https://www.ncbi.nlm.nih.gov/pubmed/36280789
http://dx.doi.org/10.1038/s41574-022-00747-7
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author Chaput, Jean-Philippe
McHill, Andrew W.
Cox, Rebecca C.
Broussard, Josiane L.
Dutil, Caroline
da Costa, Bruno G. G.
Sampasa-Kanyinga, Hugues
Wright, Kenneth P.
author_facet Chaput, Jean-Philippe
McHill, Andrew W.
Cox, Rebecca C.
Broussard, Josiane L.
Dutil, Caroline
da Costa, Bruno G. G.
Sampasa-Kanyinga, Hugues
Wright, Kenneth P.
author_sort Chaput, Jean-Philippe
collection PubMed
description Traditional risk factors for obesity and the metabolic syndrome, such as excess energy intake and lack of physical activity, cannot fully explain the high prevalence of these conditions. Insufficient sleep and circadian misalignment predispose individuals to poor metabolic health and promote weight gain and have received increased research attention in the past 10 years. Insufficient sleep is defined as sleeping less than recommended for health benefits, whereas circadian misalignment is defined as wakefulness and food intake occurring when the internal circadian system is promoting sleep. This Review discusses the impact of insufficient sleep and circadian misalignment in humans on appetite hormones (focusing on ghrelin, leptin and peptide-YY), energy expenditure, food intake and choice, and risk of obesity. Some potential strategies to reduce the adverse effects of sleep disruption on metabolic health are provided and future research priorities are highlighted. Millions of individuals worldwide do not obtain sufficient sleep for healthy metabolic functions. Furthermore, modern working patterns, lifestyles and technologies are often not conducive to adequate sleep at times when the internal physiological clock is promoting it (for example, late-night screen time, shift work and nocturnal social activities). Efforts are needed to highlight the importance of optimal sleep and circadian health in the maintenance of metabolic health and body weight regulation.
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spelling pubmed-95903982022-10-24 The role of insufficient sleep and circadian misalignment in obesity Chaput, Jean-Philippe McHill, Andrew W. Cox, Rebecca C. Broussard, Josiane L. Dutil, Caroline da Costa, Bruno G. G. Sampasa-Kanyinga, Hugues Wright, Kenneth P. Nat Rev Endocrinol Review Article Traditional risk factors for obesity and the metabolic syndrome, such as excess energy intake and lack of physical activity, cannot fully explain the high prevalence of these conditions. Insufficient sleep and circadian misalignment predispose individuals to poor metabolic health and promote weight gain and have received increased research attention in the past 10 years. Insufficient sleep is defined as sleeping less than recommended for health benefits, whereas circadian misalignment is defined as wakefulness and food intake occurring when the internal circadian system is promoting sleep. This Review discusses the impact of insufficient sleep and circadian misalignment in humans on appetite hormones (focusing on ghrelin, leptin and peptide-YY), energy expenditure, food intake and choice, and risk of obesity. Some potential strategies to reduce the adverse effects of sleep disruption on metabolic health are provided and future research priorities are highlighted. Millions of individuals worldwide do not obtain sufficient sleep for healthy metabolic functions. Furthermore, modern working patterns, lifestyles and technologies are often not conducive to adequate sleep at times when the internal physiological clock is promoting it (for example, late-night screen time, shift work and nocturnal social activities). Efforts are needed to highlight the importance of optimal sleep and circadian health in the maintenance of metabolic health and body weight regulation. Nature Publishing Group UK 2022-10-24 2023 /pmc/articles/PMC9590398/ /pubmed/36280789 http://dx.doi.org/10.1038/s41574-022-00747-7 Text en © Springer Nature Limited 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review Article
Chaput, Jean-Philippe
McHill, Andrew W.
Cox, Rebecca C.
Broussard, Josiane L.
Dutil, Caroline
da Costa, Bruno G. G.
Sampasa-Kanyinga, Hugues
Wright, Kenneth P.
The role of insufficient sleep and circadian misalignment in obesity
title The role of insufficient sleep and circadian misalignment in obesity
title_full The role of insufficient sleep and circadian misalignment in obesity
title_fullStr The role of insufficient sleep and circadian misalignment in obesity
title_full_unstemmed The role of insufficient sleep and circadian misalignment in obesity
title_short The role of insufficient sleep and circadian misalignment in obesity
title_sort role of insufficient sleep and circadian misalignment in obesity
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590398/
https://www.ncbi.nlm.nih.gov/pubmed/36280789
http://dx.doi.org/10.1038/s41574-022-00747-7
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