Cargando…

Anti-inflammatory effect of Gyeji-tang in a chronic obstructive pulmonary disease mouse model induced by cigarette smoke and lipopolysaccharide

CONTEXT: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease associated with respiratory symptoms and narrowing of airways. Gyeji-tang (GJT) is a traditional Asian medicine that has been used to relieve early-stage cold symptoms, headache, and chills. OBJECTIVE: We ex...

Descripción completa

Detalles Bibliográficos
Autores principales: Baek, Eun Bok, Kim, Yu Jin, Rho, Jin-Hyung, Hong, Eun-Ju, Lee, Mee-Young, Kwun, Hyo-Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590434/
https://www.ncbi.nlm.nih.gov/pubmed/36267048
http://dx.doi.org/10.1080/13880209.2022.2131841
_version_ 1784814511022145536
author Baek, Eun Bok
Kim, Yu Jin
Rho, Jin-Hyung
Hong, Eun-Ju
Lee, Mee-Young
Kwun, Hyo-Jung
author_facet Baek, Eun Bok
Kim, Yu Jin
Rho, Jin-Hyung
Hong, Eun-Ju
Lee, Mee-Young
Kwun, Hyo-Jung
author_sort Baek, Eun Bok
collection PubMed
description CONTEXT: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease associated with respiratory symptoms and narrowing of airways. Gyeji-tang (GJT) is a traditional Asian medicine that has been used to relieve early-stage cold symptoms, headache, and chills. OBJECTIVE: We examined the effect and potential molecular action mechanism of GJT in a mouse model of COPD induced by cigarette smoke (CS) plus lipopolysaccharide (LPS). MATERIALS AND METHODS: COPD was induced in C57BL/6J mice via daily exposure to CS for 1 h for 8 weeks and intranasal administration of LPS on weeks 1, 3, 5, and 7. GJT (100 or 200 mg/kg) or roflumilast (5 mg/kg) was administrated daily for the final 4 weeks of COPD induction. RESULTS: Administration of GJT significantly suppressed the CS/LPS-induced increases in: the numbers of total cells and macrophages in bronchoalveolar lavage fluid; the expression levels of tumour necrosis factor-α, interleukin (IL)-6, IL-1β, and IL-8; the activities (phosphorylation) of nuclear factor kappa B and signal transducer and activator of transcription 3; and the expression levels of the structural remodelling markers, transforming growth factor beta, matrix metallopeptidase (MMP)-7, and MMP-9. DISCUSSION AND CONCLUSIONS: These results demonstrate that GJT prevents the lung inflammation and airway remodelling induced by CS plus LPS exposure in mice, suggesting that GJT may have therapeutic potential for the treatment of COPD.
format Online
Article
Text
id pubmed-9590434
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-95904342022-10-25 Anti-inflammatory effect of Gyeji-tang in a chronic obstructive pulmonary disease mouse model induced by cigarette smoke and lipopolysaccharide Baek, Eun Bok Kim, Yu Jin Rho, Jin-Hyung Hong, Eun-Ju Lee, Mee-Young Kwun, Hyo-Jung Pharm Biol Research Article CONTEXT: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease associated with respiratory symptoms and narrowing of airways. Gyeji-tang (GJT) is a traditional Asian medicine that has been used to relieve early-stage cold symptoms, headache, and chills. OBJECTIVE: We examined the effect and potential molecular action mechanism of GJT in a mouse model of COPD induced by cigarette smoke (CS) plus lipopolysaccharide (LPS). MATERIALS AND METHODS: COPD was induced in C57BL/6J mice via daily exposure to CS for 1 h for 8 weeks and intranasal administration of LPS on weeks 1, 3, 5, and 7. GJT (100 or 200 mg/kg) or roflumilast (5 mg/kg) was administrated daily for the final 4 weeks of COPD induction. RESULTS: Administration of GJT significantly suppressed the CS/LPS-induced increases in: the numbers of total cells and macrophages in bronchoalveolar lavage fluid; the expression levels of tumour necrosis factor-α, interleukin (IL)-6, IL-1β, and IL-8; the activities (phosphorylation) of nuclear factor kappa B and signal transducer and activator of transcription 3; and the expression levels of the structural remodelling markers, transforming growth factor beta, matrix metallopeptidase (MMP)-7, and MMP-9. DISCUSSION AND CONCLUSIONS: These results demonstrate that GJT prevents the lung inflammation and airway remodelling induced by CS plus LPS exposure in mice, suggesting that GJT may have therapeutic potential for the treatment of COPD. Taylor & Francis 2022-10-20 /pmc/articles/PMC9590434/ /pubmed/36267048 http://dx.doi.org/10.1080/13880209.2022.2131841 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Baek, Eun Bok
Kim, Yu Jin
Rho, Jin-Hyung
Hong, Eun-Ju
Lee, Mee-Young
Kwun, Hyo-Jung
Anti-inflammatory effect of Gyeji-tang in a chronic obstructive pulmonary disease mouse model induced by cigarette smoke and lipopolysaccharide
title Anti-inflammatory effect of Gyeji-tang in a chronic obstructive pulmonary disease mouse model induced by cigarette smoke and lipopolysaccharide
title_full Anti-inflammatory effect of Gyeji-tang in a chronic obstructive pulmonary disease mouse model induced by cigarette smoke and lipopolysaccharide
title_fullStr Anti-inflammatory effect of Gyeji-tang in a chronic obstructive pulmonary disease mouse model induced by cigarette smoke and lipopolysaccharide
title_full_unstemmed Anti-inflammatory effect of Gyeji-tang in a chronic obstructive pulmonary disease mouse model induced by cigarette smoke and lipopolysaccharide
title_short Anti-inflammatory effect of Gyeji-tang in a chronic obstructive pulmonary disease mouse model induced by cigarette smoke and lipopolysaccharide
title_sort anti-inflammatory effect of gyeji-tang in a chronic obstructive pulmonary disease mouse model induced by cigarette smoke and lipopolysaccharide
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590434/
https://www.ncbi.nlm.nih.gov/pubmed/36267048
http://dx.doi.org/10.1080/13880209.2022.2131841
work_keys_str_mv AT baekeunbok antiinflammatoryeffectofgyejitanginachronicobstructivepulmonarydiseasemousemodelinducedbycigarettesmokeandlipopolysaccharide
AT kimyujin antiinflammatoryeffectofgyejitanginachronicobstructivepulmonarydiseasemousemodelinducedbycigarettesmokeandlipopolysaccharide
AT rhojinhyung antiinflammatoryeffectofgyejitanginachronicobstructivepulmonarydiseasemousemodelinducedbycigarettesmokeandlipopolysaccharide
AT hongeunju antiinflammatoryeffectofgyejitanginachronicobstructivepulmonarydiseasemousemodelinducedbycigarettesmokeandlipopolysaccharide
AT leemeeyoung antiinflammatoryeffectofgyejitanginachronicobstructivepulmonarydiseasemousemodelinducedbycigarettesmokeandlipopolysaccharide
AT kwunhyojung antiinflammatoryeffectofgyejitanginachronicobstructivepulmonarydiseasemousemodelinducedbycigarettesmokeandlipopolysaccharide