Manic Episode as a Result of Adding Trazodone to a Patient under Escitalopram Treatment

Antidepressants with hypnotic effects can often be added to treatment for sleep problems emerging in patients receiving antidepressant treatment. One of these is trazodone, which is an antidepressant that exhibits hypnotic effect by the effect of histamine H1 receptor antagonist and 5-HT2A stimulation, which is a serotonin transporter protein inhibitor and 5-HT2A and 5HT2C antagonist. Some antidepressants can cause mania-like mood episodes when used singly or in combination. In this case report, we discussed a manic episode that developed after including trazodone for sleep problems in the treatment of a patient with an anxiety disorder who uses escitalopram.