Neutropenic fever of unknown origin and disseminated granulomatous disease in a patient with acute lymphoblastic leukemia

An 18-year-old male was admitted for his second induction chemotherapy treatment for an acute lymphoblastic leukemia with cyclophosphamide, cytarabine, and mercaptopurine. Later, he presented with high fever, abdominal pain, non-bloody diarrhea, portal hypertension and leukopenia. Stool sample analy...

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Autores principales: Santarelli, Ignacio Martín, Manzella, Pedro Oscar, Ingold, Julián José, Legnoverde, Sofía, Falcón, María Florencia, Fernández, Sofía Isabel, Melero, Marcelo José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Universidad Nacional de Córdoba 2022
Materias:
Problemas Diagnósticos
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590815/
https://www.ncbi.nlm.nih.gov/pubmed/36149078
http://dx.doi.org/10.31053/1853.0605.v79.n3.34402
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author Santarelli, Ignacio Martín
Manzella, Pedro Oscar
Ingold, Julián José
Legnoverde, Sofía
Falcón, María Florencia
Fernández, Sofía Isabel
Melero, Marcelo José
author_facet Santarelli, Ignacio Martín
Manzella, Pedro Oscar
Ingold, Julián José
Legnoverde, Sofía
Falcón, María Florencia
Fernández, Sofía Isabel
Melero, Marcelo José
author_sort Santarelli, Ignacio Martín
collection PubMed
description An 18-year-old male was admitted for his second induction chemotherapy treatment for an acute lymphoblastic leukemia with cyclophosphamide, cytarabine, and mercaptopurine. Later, he presented with high fever, abdominal pain, non-bloody diarrhea, portal hypertension and leukopenia. Stool sample analysis, blood cultures and extensive work-up were negative. The only microbiologic evidence was the presence of cytomegalovirus DNA detected by PCR. A profound hypogammaglobulinemia was documented. Pathology material reported non-caseating granulomas in liver, bone marrow, duodenum and colon with negative cytomegalovirus immunostaining. What is your diagnosis?
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spelling pubmed-95908152022-10-26 Neutropenic fever of unknown origin and disseminated granulomatous disease in a patient with acute lymphoblastic leukemia Santarelli, Ignacio Martín Manzella, Pedro Oscar Ingold, Julián José Legnoverde, Sofía Falcón, María Florencia Fernández, Sofía Isabel Melero, Marcelo José Rev Fac Cien Med Univ Nac Cordoba Problemas Diagnósticos An 18-year-old male was admitted for his second induction chemotherapy treatment for an acute lymphoblastic leukemia with cyclophosphamide, cytarabine, and mercaptopurine. Later, he presented with high fever, abdominal pain, non-bloody diarrhea, portal hypertension and leukopenia. Stool sample analysis, blood cultures and extensive work-up were negative. The only microbiologic evidence was the presence of cytomegalovirus DNA detected by PCR. A profound hypogammaglobulinemia was documented. Pathology material reported non-caseating granulomas in liver, bone marrow, duodenum and colon with negative cytomegalovirus immunostaining. What is your diagnosis? Universidad Nacional de Córdoba 2022-09-16 /pmc/articles/PMC9590815/ /pubmed/36149078 http://dx.doi.org/10.31053/1853.0605.v79.n3.34402 Text en https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Problemas Diagnósticos
Santarelli, Ignacio Martín
Manzella, Pedro Oscar
Ingold, Julián José
Legnoverde, Sofía
Falcón, María Florencia
Fernández, Sofía Isabel
Melero, Marcelo José
Neutropenic fever of unknown origin and disseminated granulomatous disease in a patient with acute lymphoblastic leukemia
title Neutropenic fever of unknown origin and disseminated granulomatous disease in a patient with acute lymphoblastic leukemia
title_full Neutropenic fever of unknown origin and disseminated granulomatous disease in a patient with acute lymphoblastic leukemia
title_fullStr Neutropenic fever of unknown origin and disseminated granulomatous disease in a patient with acute lymphoblastic leukemia
title_full_unstemmed Neutropenic fever of unknown origin and disseminated granulomatous disease in a patient with acute lymphoblastic leukemia
title_short Neutropenic fever of unknown origin and disseminated granulomatous disease in a patient with acute lymphoblastic leukemia
title_sort neutropenic fever of unknown origin and disseminated granulomatous disease in a patient with acute lymphoblastic leukemia
topic Problemas Diagnósticos
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590815/
https://www.ncbi.nlm.nih.gov/pubmed/36149078
http://dx.doi.org/10.31053/1853.0605.v79.n3.34402
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