Inhibitors of ApiAP2 protein DNA binding exhibit multistage activity against Plasmodium parasites

Plasmodium parasites are reliant on the Apicomplexan AP2 (ApiAP2) transcription factor family to regulate gene expression programs. AP2 DNA binding domains have no homologs in the human or mosquito host genomes, making them potential antimalarial drug targets. Using an in-silico screen to dock thous...

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Detalles Bibliográficos
Autores principales: Russell, Timothy James, De Silva, Erandi K., Crowley, Valerie M., Shaw-Saliba, Kathryn, Dube, Namita, Josling, Gabrielle, Pasaje, Charisse Flerida A., Kouskoumvekaki, Irene, Panagiotou, Gianni, Niles, Jacquin C., Jacobs-Lorena, Marcelo, Denise Okafor, C., Gamo, Francisco-Javier, Llinás, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9591056/
https://www.ncbi.nlm.nih.gov/pubmed/36223427
http://dx.doi.org/10.1371/journal.ppat.1010887

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