Variant APOL1 protein in plasma associates with larger particles in humans and mouse models of kidney injury

BACKGROUND: Genetic variants in apolipoprotein L1 (APOL1), a protein that protects humans from infection with African trypanosomes, explain a substantial proportion of the excess risk of chronic kidney disease affecting individuals with sub-Saharan ancestry. The mechanisms by which risk variants dam...

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Detalles Bibliográficos
Autores principales: Andrews, Michael, Yoshida, Teruhiko, Henderson, Clark M., Pflaum, Hannah, McGregor, Ayako, Lieberman, Joshua A., de Boer, Ian H., Vaisar, Tomas, Himmelfarb, Jonathan, Kestenbaum, Bryan, Chung, Joon-Yong, Hewitt, Stephen M., Santo, Briana A., Ginley, Brandon, Sarder, Pinaki, Rosenberg, Avi Z., Murakami, Taichi, Kopp, Jeffrey B., Kuklenyik, Zsuzsanna, Hoofnagle, Andrew N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9591058/
https://www.ncbi.nlm.nih.gov/pubmed/36279295
http://dx.doi.org/10.1371/journal.pone.0276649

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