Cargando…

Structure of the HOPS tethering complex, a lysosomal membrane fusion machinery

Lysosomes are essential for cellular recycling, nutrient signaling, autophagy, and pathogenic bacteria and viruses invasion. Lysosomal fusion is fundamental to cell survival and requires HOPS, a conserved heterohexameric tethering complex. On the membranes to be fused, HOPS binds small membrane-asso...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shvarev, Dmitry, Schoppe, Jannis, König, Caroline, Perz, Angela, Füllbrunn, Nadia, Kiontke, Stephan, Langemeyer, Lars, Januliene, Dovile, Schnelle, Kilian, Kümmel, Daniel, Fröhlich, Florian, Moeller, Arne, Ungermann, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592082/ https://www.ncbi.nlm.nih.gov/pubmed/36098503 http://dx.doi.org/10.7554/eLife.80901

Ejemplares similares

AP‐3 vesicle uncoating occurs after HOPS‐dependent vacuole tethering
por: Schoppe, Jannis, et al.
Publicado: (2020)

A conserved and regulated mechanism drives endosomal Rab transition
por: Langemeyer, Lars, et al.
Publicado: (2020)

Phosphorylation of a membrane curvature–sensing motif switches function of the HOPS subunit Vps41 in membrane tethering
por: Cabrera, Margarita, et al.
Publicado: (2010)

Multivalent Rab interactions determine tether-mediated membrane fusion
por: Lürick, Anna, et al.
Publicado: (2017)

Architecture and mechanism of the late endosomal Rab7-like Ypt7 guanine nucleotide exchange factor complex Mon1–Ccz1
por: Kiontke, Stephan, et al.
Publicado: (2017)

The vacuolar kinase Yck3 maintains organelle fragmentation by regulating the HOPS tethering complex
por: LaGrassa, Tracy J., et al.
Publicado: (2005)

The HOPS tethering complex is required to maintain signaling endosome identity and TORC1 activity
por: Gao, Jieqiong, et al.
Publicado: (2022)

Structure of the Mon1-Ccz1 complex reveals molecular basis of membrane binding for Rab7 activation
por: Klink, Björn U., et al.
Publicado: (2022)

Subunit Organisation of In Vitro Reconstituted HOPS and CORVET Multisubunit Membrane Tethering Complexes
por: Guo, Zhong, et al.
Publicado: (2013)

Correction: Subunit Organisation of In Vitro Reconstituted HOPS and CORVET Multisubunit Membrane Tethering Complexes
por: Guo, Zhong, et al.
Publicado: (2014)

Consecutive functions of small GTPases guide HOPS-mediated tethering of late endosomes and lysosomes
por: Schleinitz, Ariane, et al.
Publicado: (2023)

Regulatory sites in the Mon1–Ccz1 complex control Rab5 to Rab7 transition and endosome maturation
por: Borchers, Ann-Christin, et al.
Publicado: (2023)

Molecular mechanism to target the endosomal Mon1-Ccz1 GEF complex to the pre-autophagosomal structure
por: Gao, Jieqiong, et al.
Publicado: (2018)

Structure of Merkel Cell Polyomavirus Capsid and Interaction with Its Glycosaminoglycan Attachment Receptor
por: Bayer, Niklas J., et al.
Publicado: (2020)

Structure of the ceramide-bound SPOTS complex
por: Schäfer, Jan-Hannes, et al.
Publicado: (2023)

How Vps41 HOPS between tethering functions
por: Short, Ben
Publicado: (2010)

Flexible open conformation of the AP-3 complex explains its role in cargo recruitment at the Golgi
por: Schoppe, Jannis, et al.
Publicado: (2021)

Subunit exchange among endolysosomal tethering complexes is linked to contact site formation at the vacuole
por: González Montoro, Ayelén, et al.
Publicado: (2021)

Structure of the metazoan Rab7 GEF complex Mon1–Ccz1–Bulli
por: Herrmann, Eric, et al.
Publicado: (2023)

C9orf72-catalyzed GTP loading of Rab39A enables HOPS-mediated membrane tethering and fusion in mammalian autophagy
por: Zhang, Shen, et al.
Publicado: (2023)

CATCHR and HOPS-CORVET tethering complexes share a similar architecture
por: Chou, Hui-Ting, et al.
Publicado: (2016)

Nanoscopic anatomy of dynamic multi-protein complexes at membranes resolved by graphene-induced energy transfer
por: Füllbrunn, Nadia, et al.
Publicado: (2021)

Conformational variability of cyanobacterial ChlI, the AAA+ motor of magnesium chelatase involved in chlorophyll biosynthesis
por: Shvarev, Dmitry, et al.
Publicado: (2023)

Who’s in control? Principles of Rab GTPase activation in endolysosomal membrane trafficking and beyond
por: Borchers, Ann-Christin, et al.
Publicado: (2021)

HOPS Initiates Vacuole Docking by Tethering Membranes before trans-SNARE Complex Assembly
por: Hickey, Christopher M., et al.
Publicado: (2010)

The N-Terminal Domains of Vps3 and Vps8 Are Critical for Localization and Function of the CORVET Tethering Complex on Endosomes
por: Epp, Nadine, et al.
Publicado: (2013)

Salmonella exploits the host endolysosomal tethering factor HOPS complex to promote its intravacuolar replication
por: Sindhwani, Aastha, et al.
Publicado: (2017)

HOPS drives vacuole fusion by binding the vacuolar SNARE complex and the Vam7 PX domain via two distinct sites
por: Krämer, Lukas, et al.
Publicado: (2011)

Conformation space of a heterodimeric ABC exporter under turnover conditions
por: Hofmann, Susanne, et al.
Publicado: (2019)

A lysosomal biogenesis map reveals the cargo spectrum of yeast vacuolar protein targeting pathways
por: Eising, Sebastian, et al.
Publicado: (2022)

The tethering complex HOPS catalyzes assembly of the soluble SNARE Vam7 into fusogenic trans-SNARE complexes
por: Zick, Michael, et al.
Publicado: (2013)

HOPS, CORVET and newly-identified Hybrid tethering complexes contribute differentially towards multiple modes of endocytosis
por: Terawaki, Seigo, et al.
Publicado: (2023)

The HOPS complex mediates autophagosome–lysosome fusion through interaction with syntaxin 17
por: Jiang, Peidu, et al.
Publicado: (2014)

HOPS‐Associated Neurological Disorders: Lysosomal Dysfunction as an Emerging Concept Underlying Dystonia
por: Schreglmann, Sebastian R., et al.
Publicado: (2022)

Tracking of the dynamic localization of the Rab-specific HOPS subunits reveal their distinct interaction with Ypt7 and vacuoles
por: Auffarth, Kathrin, et al.
Publicado: (2014)

Live cell microscopy of mitochondria-lysosome contact site formation and tethering dynamics
por: Belton, Tayler B., et al.
Publicado: (2022)

The HOPS/class C Vps complex tethers membranes by binding to one Rab GTPase in each apposed membrane
por: Ho, Ruoya, et al.
Publicado: (2015)

Fusion of tethered membranes can be driven by Sec18/NSF and Sec17/αSNAP without HOPS
por: Song, Hongki, et al.
Publicado: (2021)

The ABC transporter MsbA adopts the wide inward-open conformation in E. coli cells
por: Galazzo, Laura, et al.
Publicado: (2022)

The small GTPase Arl8b regulates assembly of the mammalian HOPS complex on lysosomes
por: Khatter, Divya, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_odrbdv2ge5id86minufbkppatb