Endophytic fungus Phomopsis sp. as a source of 3-nitropropionic acid with larvicidal activity against Aedes aegypti (Linnaeus 1762, Diptera: Culicidae)

BACKGROUND: Aedes aegypti is the primary vector of viruses, such as Zika, chikungunya, yellow fever, and dengue. In this context, a biomonitored chemical study was conducted to evaluate the activity of the crude extract of the endophytic fungus Phomopsis sp. against the larvae of Aedes aegypti. METH...

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Detalles Bibliográficos
Autores principales: Garcia, Armando da Costa, de Menezes, Orivaldo Teixeira, Mariano, Lissa Apolonia, Santiago, Letícia Corrêa, Araújo, Ângela Regina, Monfardini, Julia Dietsche, Simões, Rejane de Castro, de Oliveira, André Correa, Roque, Rosemary Aparecida, Tadei, Wanderli Pedro, Teles, Helder Lopes, de Oliveira, Camila Martins
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Medicina Tropical - SBMT 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592098/
https://www.ncbi.nlm.nih.gov/pubmed/36287467
http://dx.doi.org/10.1590/0037-8682-0018-2022
Descripción
Sumario:BACKGROUND: Aedes aegypti is the primary vector of viruses, such as Zika, chikungunya, yellow fever, and dengue. In this context, a biomonitored chemical study was conducted to evaluate the activity of the crude extract of the endophytic fungus Phomopsis sp. against the larvae of Aedes aegypti. METHODS: Crude extract, fractions, and isolated substances were evaluated in in-vitro assays against third-stage larvae of Aedes aegypti. RESULTS: We isolated 3-nitropropionic acid with an LC(50) of 15.172 ppm and LC(90) of 18.178 ppm after 24 hours of larval exposure. CONCLUSIONS: The results indicated that 3-nitropropionic acid exerted larvicidal activity.

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