Anti-SARS-CoV-2 antibody immunoreactivity profiles during COVID-19 recurrence

BACKGROUND: This study aimed to evaluate IgG and IgM levels in COVID-19 recurrence. METHODS: The serum antibody levels and clinical data from 73 healthcare workers with SARS-CoV-2 divided into seroconverted (n=51) and non-seroconverted (n=22) groups were assessed. The presence of specific anti-nucle...

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Autores principales: Gouvea, Maria da Penha Gomes, Moulaz, Isac Ribeiro, Gouveia, Thayná Martins, Lança, Karen Evelin Monlevade, Lacerda, Bárbara Sthefany de Paula, Thompson, Beatriz Paoli, Polese, Jéssica, de Lima, Marina Deorce, Ribeiro-Rodrigues, Rodrigo, Mill, José Geraldo, Valim, Valéria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Medicina Tropical - SBMT 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592100/
https://www.ncbi.nlm.nih.gov/pubmed/36287469
http://dx.doi.org/10.1590/0037-8682-0106-2022
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author Gouvea, Maria da Penha Gomes
Moulaz, Isac Ribeiro
Gouveia, Thayná Martins
Lança, Karen Evelin Monlevade
Lacerda, Bárbara Sthefany de Paula
Thompson, Beatriz Paoli
Polese, Jéssica
de Lima, Marina Deorce
Ribeiro-Rodrigues, Rodrigo
Mill, José Geraldo
Valim, Valéria
author_facet Gouvea, Maria da Penha Gomes
Moulaz, Isac Ribeiro
Gouveia, Thayná Martins
Lança, Karen Evelin Monlevade
Lacerda, Bárbara Sthefany de Paula
Thompson, Beatriz Paoli
Polese, Jéssica
de Lima, Marina Deorce
Ribeiro-Rodrigues, Rodrigo
Mill, José Geraldo
Valim, Valéria
author_sort Gouvea, Maria da Penha Gomes
collection PubMed
description BACKGROUND: This study aimed to evaluate IgG and IgM levels in COVID-19 recurrence. METHODS: The serum antibody levels and clinical data from 73 healthcare workers with SARS-CoV-2 divided into seroconverted (n=51) and non-seroconverted (n=22) groups were assessed. The presence of specific anti-nucleocapsid (anti-N) IgM and IgG for SARS-CoV-2 was evaluated. IgG antibodies to the SARS-CoV-2 spike receptor-binding domain were used to confirm non-seroconversion in all negative anti-N. RESULTS: Four recurrent cases displayed mild symptoms and were non-seroconverted until the recurrence of symptoms. CONCLUSIONS: Undetectable anti-nucleocapsid IgM and IgG levels may be correlated with symptomatic COVID-19 recurrence.
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spelling pubmed-95921002022-11-04 Anti-SARS-CoV-2 antibody immunoreactivity profiles during COVID-19 recurrence Gouvea, Maria da Penha Gomes Moulaz, Isac Ribeiro Gouveia, Thayná Martins Lança, Karen Evelin Monlevade Lacerda, Bárbara Sthefany de Paula Thompson, Beatriz Paoli Polese, Jéssica de Lima, Marina Deorce Ribeiro-Rodrigues, Rodrigo Mill, José Geraldo Valim, Valéria Rev Soc Bras Med Trop Short Communication BACKGROUND: This study aimed to evaluate IgG and IgM levels in COVID-19 recurrence. METHODS: The serum antibody levels and clinical data from 73 healthcare workers with SARS-CoV-2 divided into seroconverted (n=51) and non-seroconverted (n=22) groups were assessed. The presence of specific anti-nucleocapsid (anti-N) IgM and IgG for SARS-CoV-2 was evaluated. IgG antibodies to the SARS-CoV-2 spike receptor-binding domain were used to confirm non-seroconversion in all negative anti-N. RESULTS: Four recurrent cases displayed mild symptoms and were non-seroconverted until the recurrence of symptoms. CONCLUSIONS: Undetectable anti-nucleocapsid IgM and IgG levels may be correlated with symptomatic COVID-19 recurrence. Sociedade Brasileira de Medicina Tropical - SBMT 2022-10-24 /pmc/articles/PMC9592100/ /pubmed/36287469 http://dx.doi.org/10.1590/0037-8682-0106-2022 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Short Communication
Gouvea, Maria da Penha Gomes
Moulaz, Isac Ribeiro
Gouveia, Thayná Martins
Lança, Karen Evelin Monlevade
Lacerda, Bárbara Sthefany de Paula
Thompson, Beatriz Paoli
Polese, Jéssica
de Lima, Marina Deorce
Ribeiro-Rodrigues, Rodrigo
Mill, José Geraldo
Valim, Valéria
Anti-SARS-CoV-2 antibody immunoreactivity profiles during COVID-19 recurrence
title Anti-SARS-CoV-2 antibody immunoreactivity profiles during COVID-19 recurrence
title_full Anti-SARS-CoV-2 antibody immunoreactivity profiles during COVID-19 recurrence
title_fullStr Anti-SARS-CoV-2 antibody immunoreactivity profiles during COVID-19 recurrence
title_full_unstemmed Anti-SARS-CoV-2 antibody immunoreactivity profiles during COVID-19 recurrence
title_short Anti-SARS-CoV-2 antibody immunoreactivity profiles during COVID-19 recurrence
title_sort anti-sars-cov-2 antibody immunoreactivity profiles during covid-19 recurrence
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592100/
https://www.ncbi.nlm.nih.gov/pubmed/36287469
http://dx.doi.org/10.1590/0037-8682-0106-2022
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