A potent inflammatory response is triggered in asymptomatic blood donors with recent SARS-CoV-2 infection

BACKGROUND: The inflammatory response plays a significant role in the outcome of coronavirus disease (COVID-19). METHODS: We investigated plasma cytokine and chemokine concentrations in non-infected (NI), asymptomatic severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)-infected blood donors...

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Detalles Bibliográficos
Autores principales: Martins, Marina Lobato, da Silva-Malta, Maria Clara Fernandes, Araújo, Argus Leão, Gonçalves, Fabíola Araújo, Botelho, Maiara de Lourdes, de Oliveira, Isabelle Rocha, Boy, Luciana de Souza Madeira Ferreira, Moreira, Hélinse Medeiros, Barbosa-Stancioli, Edel Figueiredo, Ribeiro, Maísa Aparecida, Chaves, Daniel Gonçalves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Medicina Tropical - SBMT 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592101/
https://www.ncbi.nlm.nih.gov/pubmed/36287506
http://dx.doi.org/10.1590/0037-8682-0239-2022
Descripción
Sumario:BACKGROUND: The inflammatory response plays a significant role in the outcome of coronavirus disease (COVID-19). METHODS: We investigated plasma cytokine and chemokine concentrations in non-infected (NI), asymptomatic severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)-infected blood donors (AS), and patients with severe COVID-19 (SC). RESULTS: The SC group showed significantly higher levels of interleukin 6 (IL-6), IL-10, and CCL5 than the AS and NI groups. The SC and AS groups had considerably greater CXCL9 and CXCL10 concentrations than the NI group. Only NI and infected people showed separate clusters in the principal component analysis. CONCLUSIONS: SC, as well as AS was characterized by an inflammatory profile.

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