A potent inflammatory response is triggered in asymptomatic blood donors with recent SARS-CoV-2 infection

BACKGROUND: The inflammatory response plays a significant role in the outcome of coronavirus disease (COVID-19). METHODS: We investigated plasma cytokine and chemokine concentrations in non-infected (NI), asymptomatic severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)-infected blood donors...

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Autores principales: Martins, Marina Lobato, da Silva-Malta, Maria Clara Fernandes, Araújo, Argus Leão, Gonçalves, Fabíola Araújo, Botelho, Maiara de Lourdes, de Oliveira, Isabelle Rocha, Boy, Luciana de Souza Madeira Ferreira, Moreira, Hélinse Medeiros, Barbosa-Stancioli, Edel Figueiredo, Ribeiro, Maísa Aparecida, Chaves, Daniel Gonçalves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Medicina Tropical - SBMT 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592101/
https://www.ncbi.nlm.nih.gov/pubmed/36287506
http://dx.doi.org/10.1590/0037-8682-0239-2022
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author Martins, Marina Lobato
da Silva-Malta, Maria Clara Fernandes
Araújo, Argus Leão
Gonçalves, Fabíola Araújo
Botelho, Maiara de Lourdes
de Oliveira, Isabelle Rocha
Boy, Luciana de Souza Madeira Ferreira
Moreira, Hélinse Medeiros
Barbosa-Stancioli, Edel Figueiredo
Ribeiro, Maísa Aparecida
Chaves, Daniel Gonçalves
author_facet Martins, Marina Lobato
da Silva-Malta, Maria Clara Fernandes
Araújo, Argus Leão
Gonçalves, Fabíola Araújo
Botelho, Maiara de Lourdes
de Oliveira, Isabelle Rocha
Boy, Luciana de Souza Madeira Ferreira
Moreira, Hélinse Medeiros
Barbosa-Stancioli, Edel Figueiredo
Ribeiro, Maísa Aparecida
Chaves, Daniel Gonçalves
author_sort Martins, Marina Lobato
collection PubMed
description BACKGROUND: The inflammatory response plays a significant role in the outcome of coronavirus disease (COVID-19). METHODS: We investigated plasma cytokine and chemokine concentrations in non-infected (NI), asymptomatic severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)-infected blood donors (AS), and patients with severe COVID-19 (SC). RESULTS: The SC group showed significantly higher levels of interleukin 6 (IL-6), IL-10, and CCL5 than the AS and NI groups. The SC and AS groups had considerably greater CXCL9 and CXCL10 concentrations than the NI group. Only NI and infected people showed separate clusters in the principal component analysis. CONCLUSIONS: SC, as well as AS was characterized by an inflammatory profile.
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spelling pubmed-95921012022-11-04 A potent inflammatory response is triggered in asymptomatic blood donors with recent SARS-CoV-2 infection Martins, Marina Lobato da Silva-Malta, Maria Clara Fernandes Araújo, Argus Leão Gonçalves, Fabíola Araújo Botelho, Maiara de Lourdes de Oliveira, Isabelle Rocha Boy, Luciana de Souza Madeira Ferreira Moreira, Hélinse Medeiros Barbosa-Stancioli, Edel Figueiredo Ribeiro, Maísa Aparecida Chaves, Daniel Gonçalves Rev Soc Bras Med Trop Short Communication BACKGROUND: The inflammatory response plays a significant role in the outcome of coronavirus disease (COVID-19). METHODS: We investigated plasma cytokine and chemokine concentrations in non-infected (NI), asymptomatic severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)-infected blood donors (AS), and patients with severe COVID-19 (SC). RESULTS: The SC group showed significantly higher levels of interleukin 6 (IL-6), IL-10, and CCL5 than the AS and NI groups. The SC and AS groups had considerably greater CXCL9 and CXCL10 concentrations than the NI group. Only NI and infected people showed separate clusters in the principal component analysis. CONCLUSIONS: SC, as well as AS was characterized by an inflammatory profile. Sociedade Brasileira de Medicina Tropical - SBMT 2022-10-21 /pmc/articles/PMC9592101/ /pubmed/36287506 http://dx.doi.org/10.1590/0037-8682-0239-2022 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Short Communication
Martins, Marina Lobato
da Silva-Malta, Maria Clara Fernandes
Araújo, Argus Leão
Gonçalves, Fabíola Araújo
Botelho, Maiara de Lourdes
de Oliveira, Isabelle Rocha
Boy, Luciana de Souza Madeira Ferreira
Moreira, Hélinse Medeiros
Barbosa-Stancioli, Edel Figueiredo
Ribeiro, Maísa Aparecida
Chaves, Daniel Gonçalves
A potent inflammatory response is triggered in asymptomatic blood donors with recent SARS-CoV-2 infection
title A potent inflammatory response is triggered in asymptomatic blood donors with recent SARS-CoV-2 infection
title_full A potent inflammatory response is triggered in asymptomatic blood donors with recent SARS-CoV-2 infection
title_fullStr A potent inflammatory response is triggered in asymptomatic blood donors with recent SARS-CoV-2 infection
title_full_unstemmed A potent inflammatory response is triggered in asymptomatic blood donors with recent SARS-CoV-2 infection
title_short A potent inflammatory response is triggered in asymptomatic blood donors with recent SARS-CoV-2 infection
title_sort potent inflammatory response is triggered in asymptomatic blood donors with recent sars-cov-2 infection
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592101/
https://www.ncbi.nlm.nih.gov/pubmed/36287506
http://dx.doi.org/10.1590/0037-8682-0239-2022
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