Evaluation of aversive behavior in Rattus norvegicus experimentally infected by two distinct strains of Toxoplasma gondii (ME49 and VEG): study of epigenetic markers

BACKGROUND: Behavioral changes in Rattus norvegicus infected with two strains of Toxoplasma gondii (ME49 and VEG) were investigated. METHODS: Rats were evaluated for motor activity and aversion or attraction to cat urine 60 days after infection. After euthanasia, arginine-vasopressin gene methylatio...

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Autores principales: dos Santos, Sergio Vieira, Fortuna, Giulio de los Santos, Barbosa, Lariane Monteiro, Meireles, Luciana Regina, Tiago, Érico Silva, Chieffi, Pedro Paulo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Medicina Tropical - SBMT 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592110/
https://www.ncbi.nlm.nih.gov/pubmed/36287471
http://dx.doi.org/10.1590/0037-8682-0122-2022
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author dos Santos, Sergio Vieira
Fortuna, Giulio de los Santos
Barbosa, Lariane Monteiro
Meireles, Luciana Regina
Tiago, Érico Silva
Chieffi, Pedro Paulo
author_facet dos Santos, Sergio Vieira
Fortuna, Giulio de los Santos
Barbosa, Lariane Monteiro
Meireles, Luciana Regina
Tiago, Érico Silva
Chieffi, Pedro Paulo
author_sort dos Santos, Sergio Vieira
collection PubMed
description BACKGROUND: Behavioral changes in Rattus norvegicus infected with two strains of Toxoplasma gondii (ME49 and VEG) were investigated. METHODS: Rats were evaluated for motor activity and aversion or attraction to cat urine 60 days after infection. After euthanasia, arginine-vasopressin gene methylation in the central nervous system was evaluated. RESULTS: A significant difference was observed in the methylation of the arginine-vasopressin promoter gene between rats infected with the ME49 and VEG strains. CONCLUSIONS: Although differences were not observed in many parameters, significant differences were observed in the methylation of the arginine-vasopressin promoter gene in rats infected with the two studied strains.
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spelling pubmed-95921102022-11-04 Evaluation of aversive behavior in Rattus norvegicus experimentally infected by two distinct strains of Toxoplasma gondii (ME49 and VEG): study of epigenetic markers dos Santos, Sergio Vieira Fortuna, Giulio de los Santos Barbosa, Lariane Monteiro Meireles, Luciana Regina Tiago, Érico Silva Chieffi, Pedro Paulo Rev Soc Bras Med Trop Short Communication BACKGROUND: Behavioral changes in Rattus norvegicus infected with two strains of Toxoplasma gondii (ME49 and VEG) were investigated. METHODS: Rats were evaluated for motor activity and aversion or attraction to cat urine 60 days after infection. After euthanasia, arginine-vasopressin gene methylation in the central nervous system was evaluated. RESULTS: A significant difference was observed in the methylation of the arginine-vasopressin promoter gene between rats infected with the ME49 and VEG strains. CONCLUSIONS: Although differences were not observed in many parameters, significant differences were observed in the methylation of the arginine-vasopressin promoter gene in rats infected with the two studied strains. Sociedade Brasileira de Medicina Tropical - SBMT 2022-10-24 /pmc/articles/PMC9592110/ /pubmed/36287471 http://dx.doi.org/10.1590/0037-8682-0122-2022 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Short Communication
dos Santos, Sergio Vieira
Fortuna, Giulio de los Santos
Barbosa, Lariane Monteiro
Meireles, Luciana Regina
Tiago, Érico Silva
Chieffi, Pedro Paulo
Evaluation of aversive behavior in Rattus norvegicus experimentally infected by two distinct strains of Toxoplasma gondii (ME49 and VEG): study of epigenetic markers
title Evaluation of aversive behavior in Rattus norvegicus experimentally infected by two distinct strains of Toxoplasma gondii (ME49 and VEG): study of epigenetic markers
title_full Evaluation of aversive behavior in Rattus norvegicus experimentally infected by two distinct strains of Toxoplasma gondii (ME49 and VEG): study of epigenetic markers
title_fullStr Evaluation of aversive behavior in Rattus norvegicus experimentally infected by two distinct strains of Toxoplasma gondii (ME49 and VEG): study of epigenetic markers
title_full_unstemmed Evaluation of aversive behavior in Rattus norvegicus experimentally infected by two distinct strains of Toxoplasma gondii (ME49 and VEG): study of epigenetic markers
title_short Evaluation of aversive behavior in Rattus norvegicus experimentally infected by two distinct strains of Toxoplasma gondii (ME49 and VEG): study of epigenetic markers
title_sort evaluation of aversive behavior in rattus norvegicus experimentally infected by two distinct strains of toxoplasma gondii (me49 and veg): study of epigenetic markers
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592110/
https://www.ncbi.nlm.nih.gov/pubmed/36287471
http://dx.doi.org/10.1590/0037-8682-0122-2022
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