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Clomiphene citrate mild stimulation improved follicular development outcomes in PCOS women with high luteinizing hormone and poor ovarian response: A case report

Polycystic ovary syndrome (PCOS) is a main cause of anovulatory infertility in women of reproductive age. About 30% to 50% of patients with PCOS has high serum basal luteinizing hormone (LH) levels, and almost 5% of PCOS women with high LH have poor ovarian response (POR). We reported a case of a PC...

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Autores principales: Yang, Xiaojing, Jiang, Meiyan, Deng, Miao, Zhang, Huanhuan, Lin, Zhenyun, Fei, Xiaoyang, Zhang, Hongyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592273/
https://www.ncbi.nlm.nih.gov/pubmed/36281179
http://dx.doi.org/10.1097/MD.0000000000031323
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author Yang, Xiaojing
Jiang, Meiyan
Deng, Miao
Zhang, Huanhuan
Lin, Zhenyun
Fei, Xiaoyang
Zhang, Hongyan
author_facet Yang, Xiaojing
Jiang, Meiyan
Deng, Miao
Zhang, Huanhuan
Lin, Zhenyun
Fei, Xiaoyang
Zhang, Hongyan
author_sort Yang, Xiaojing
collection PubMed
description Polycystic ovary syndrome (PCOS) is a main cause of anovulatory infertility in women of reproductive age. About 30% to 50% of patients with PCOS has high serum basal luteinizing hormone (LH) levels, and almost 5% of PCOS women with high LH have poor ovarian response (POR). We reported a case of a PCOS woman with high basal LH levels who canceled due to POR during two consecutive controlled ovarian stimulation treatments, which was considered to be related to the suppression of LH levels during downregulation. Clomiphene citrate (CC) combined with human menopausal urinary gonadotropin (HMG) mild regimen did not affect LH levels and obtained good follicular development, providing a new treatment insight for patients with PCOS combined with POR. PATIENT CONCERNS: A 28-year-old PCOS woman with high basal LH levels, underwent IVF assisted pregnancy treatment in our hospital, whom canceled due to POR during two traditional controlled ovulation induction program. Follicular development was finally achieved with CC milder protocol. DIAGNOSIS: This patient with the diagnosis of PCOS was undergone IVF assisted pregnancy treatment in our hospital. INTERVENTIONS: CC protocol supports the development of follicular. OUTCOMES: CC protocol resulted in better follicular development and high-quality embryos due to the continuous maintenance of an elevated LH levels. CONCLUSION: PCOS women with poor ovarian response required relatively higher LH to maintain the normal development of follicles.
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spelling pubmed-95922732022-10-25 Clomiphene citrate mild stimulation improved follicular development outcomes in PCOS women with high luteinizing hormone and poor ovarian response: A case report Yang, Xiaojing Jiang, Meiyan Deng, Miao Zhang, Huanhuan Lin, Zhenyun Fei, Xiaoyang Zhang, Hongyan Medicine (Baltimore) Research Article Polycystic ovary syndrome (PCOS) is a main cause of anovulatory infertility in women of reproductive age. About 30% to 50% of patients with PCOS has high serum basal luteinizing hormone (LH) levels, and almost 5% of PCOS women with high LH have poor ovarian response (POR). We reported a case of a PCOS woman with high basal LH levels who canceled due to POR during two consecutive controlled ovarian stimulation treatments, which was considered to be related to the suppression of LH levels during downregulation. Clomiphene citrate (CC) combined with human menopausal urinary gonadotropin (HMG) mild regimen did not affect LH levels and obtained good follicular development, providing a new treatment insight for patients with PCOS combined with POR. PATIENT CONCERNS: A 28-year-old PCOS woman with high basal LH levels, underwent IVF assisted pregnancy treatment in our hospital, whom canceled due to POR during two traditional controlled ovulation induction program. Follicular development was finally achieved with CC milder protocol. DIAGNOSIS: This patient with the diagnosis of PCOS was undergone IVF assisted pregnancy treatment in our hospital. INTERVENTIONS: CC protocol supports the development of follicular. OUTCOMES: CC protocol resulted in better follicular development and high-quality embryos due to the continuous maintenance of an elevated LH levels. CONCLUSION: PCOS women with poor ovarian response required relatively higher LH to maintain the normal development of follicles. Lippincott Williams & Wilkins 2022-10-21 /pmc/articles/PMC9592273/ /pubmed/36281179 http://dx.doi.org/10.1097/MD.0000000000031323 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yang, Xiaojing
Jiang, Meiyan
Deng, Miao
Zhang, Huanhuan
Lin, Zhenyun
Fei, Xiaoyang
Zhang, Hongyan
Clomiphene citrate mild stimulation improved follicular development outcomes in PCOS women with high luteinizing hormone and poor ovarian response: A case report
title Clomiphene citrate mild stimulation improved follicular development outcomes in PCOS women with high luteinizing hormone and poor ovarian response: A case report
title_full Clomiphene citrate mild stimulation improved follicular development outcomes in PCOS women with high luteinizing hormone and poor ovarian response: A case report
title_fullStr Clomiphene citrate mild stimulation improved follicular development outcomes in PCOS women with high luteinizing hormone and poor ovarian response: A case report
title_full_unstemmed Clomiphene citrate mild stimulation improved follicular development outcomes in PCOS women with high luteinizing hormone and poor ovarian response: A case report
title_short Clomiphene citrate mild stimulation improved follicular development outcomes in PCOS women with high luteinizing hormone and poor ovarian response: A case report
title_sort clomiphene citrate mild stimulation improved follicular development outcomes in pcos women with high luteinizing hormone and poor ovarian response: a case report
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592273/
https://www.ncbi.nlm.nih.gov/pubmed/36281179
http://dx.doi.org/10.1097/MD.0000000000031323
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