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Intensity modulated radiotherapy might be effective for locally advanced esophageal carcinosarcoma: A single center’s experience and review of literature

Esophageal carcinosarcoma is a rare type of esophageal cancer; however, few studies have investigated the effects of radiotherapy in locally advanced patients. This study aimed to report experience of the safety and efficacy of intensity-modulated radiotherapy for locally advanced esophageal carcino...

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Autores principales: Yang, Siran, Wang, Wenqing, Bi, Nan, Zhou, Zongmei, Feng, Qinfu, Xiao, Zefen, Chen, Dongfu, Liang, Jun, Lu, Jima, Wang, Jianyang, Wang, Xin, Wang, Jingbo, Yang, Yong, Lu, Ningning, Zhang, Hongxing, Wang, Luhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592314/
https://www.ncbi.nlm.nih.gov/pubmed/36281080
http://dx.doi.org/10.1097/MD.0000000000031215
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author Yang, Siran
Wang, Wenqing
Bi, Nan
Zhou, Zongmei
Feng, Qinfu
Xiao, Zefen
Chen, Dongfu
Liang, Jun
Lu, Jima
Wang, Jianyang
Wang, Xin
Wang, Jingbo
Yang, Yong
Lu, Ningning
Zhang, Hongxing
Wang, Luhua
author_facet Yang, Siran
Wang, Wenqing
Bi, Nan
Zhou, Zongmei
Feng, Qinfu
Xiao, Zefen
Chen, Dongfu
Liang, Jun
Lu, Jima
Wang, Jianyang
Wang, Xin
Wang, Jingbo
Yang, Yong
Lu, Ningning
Zhang, Hongxing
Wang, Luhua
author_sort Yang, Siran
collection PubMed
description Esophageal carcinosarcoma is a rare type of esophageal cancer; however, few studies have investigated the effects of radiotherapy in locally advanced patients. This study aimed to report experience of the safety and efficacy of intensity-modulated radiotherapy for locally advanced esophageal carcinosarcoma and review the literature. By searching the institutional database between January 2010 and December 2020, along with the literature review, 25 patients were eligible for the study. The clinical and radiologic information of all patients with esophageal carcinosarcoma who underwent radiotherapy were collected. Survival outcomes were calculated using Kaplan–Meier plots. In our series, 5 patients were in the curative/neoadjuvant radiotherapy group and 10 patients were in the adjuvant group. Most tumors were protruding (n = 10, 66.7%). All patients underwent intensity-modulated radiotherapy. In the curative/neoadjuvant radiotherapy group, 2 patients underwent concurrent chemoradiotherapy before surgery, and the other three received radiotherapy alone as the initial treatment. The median follow-up time was 43.1 months. All patients showed a partial response at the efficacy evaluation. The median time of overall survival and progression-free survival were 40.2 months (95% confidence interval [CI], 13.1–67.3 months) and 19.0 months (95% CI, 13.9 months—24.1 months) for the entire cohort, but were not reached for curative/neoadjuvant radiotherapy group. Overall survival (hazard ratio [HR] 0.81, 95% CI, 0.15–4.43; P = .805) and progression-free survival (HR 1.68, 95% CI, 0.35–8.19; P = .514) did not differ significantly between the 2 groups. When considering the literature review data in the final analysis, overall survival (HR 0.84, 95% CI, 0.25–2.81; P = .779) and progression-free survival (HR, 0.68; 95% CI, 0.26–1.76; P = .425) were also not different between the 2 groups. Treatment based on intensity-modulated radiotherapy with neoadjuvant or curative intent may be an option for patients with unresectable esophageal carcinosarcoma. Further research with a larger sample size is needed to validate the reliability.
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spelling pubmed-95923142022-10-25 Intensity modulated radiotherapy might be effective for locally advanced esophageal carcinosarcoma: A single center’s experience and review of literature Yang, Siran Wang, Wenqing Bi, Nan Zhou, Zongmei Feng, Qinfu Xiao, Zefen Chen, Dongfu Liang, Jun Lu, Jima Wang, Jianyang Wang, Xin Wang, Jingbo Yang, Yong Lu, Ningning Zhang, Hongxing Wang, Luhua Medicine (Baltimore) 5700 Esophageal carcinosarcoma is a rare type of esophageal cancer; however, few studies have investigated the effects of radiotherapy in locally advanced patients. This study aimed to report experience of the safety and efficacy of intensity-modulated radiotherapy for locally advanced esophageal carcinosarcoma and review the literature. By searching the institutional database between January 2010 and December 2020, along with the literature review, 25 patients were eligible for the study. The clinical and radiologic information of all patients with esophageal carcinosarcoma who underwent radiotherapy were collected. Survival outcomes were calculated using Kaplan–Meier plots. In our series, 5 patients were in the curative/neoadjuvant radiotherapy group and 10 patients were in the adjuvant group. Most tumors were protruding (n = 10, 66.7%). All patients underwent intensity-modulated radiotherapy. In the curative/neoadjuvant radiotherapy group, 2 patients underwent concurrent chemoradiotherapy before surgery, and the other three received radiotherapy alone as the initial treatment. The median follow-up time was 43.1 months. All patients showed a partial response at the efficacy evaluation. The median time of overall survival and progression-free survival were 40.2 months (95% confidence interval [CI], 13.1–67.3 months) and 19.0 months (95% CI, 13.9 months—24.1 months) for the entire cohort, but were not reached for curative/neoadjuvant radiotherapy group. Overall survival (hazard ratio [HR] 0.81, 95% CI, 0.15–4.43; P = .805) and progression-free survival (HR 1.68, 95% CI, 0.35–8.19; P = .514) did not differ significantly between the 2 groups. When considering the literature review data in the final analysis, overall survival (HR 0.84, 95% CI, 0.25–2.81; P = .779) and progression-free survival (HR, 0.68; 95% CI, 0.26–1.76; P = .425) were also not different between the 2 groups. Treatment based on intensity-modulated radiotherapy with neoadjuvant or curative intent may be an option for patients with unresectable esophageal carcinosarcoma. Further research with a larger sample size is needed to validate the reliability. Lippincott Williams & Wilkins 2022-10-21 /pmc/articles/PMC9592314/ /pubmed/36281080 http://dx.doi.org/10.1097/MD.0000000000031215 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle 5700
Yang, Siran
Wang, Wenqing
Bi, Nan
Zhou, Zongmei
Feng, Qinfu
Xiao, Zefen
Chen, Dongfu
Liang, Jun
Lu, Jima
Wang, Jianyang
Wang, Xin
Wang, Jingbo
Yang, Yong
Lu, Ningning
Zhang, Hongxing
Wang, Luhua
Intensity modulated radiotherapy might be effective for locally advanced esophageal carcinosarcoma: A single center’s experience and review of literature
title Intensity modulated radiotherapy might be effective for locally advanced esophageal carcinosarcoma: A single center’s experience and review of literature
title_full Intensity modulated radiotherapy might be effective for locally advanced esophageal carcinosarcoma: A single center’s experience and review of literature
title_fullStr Intensity modulated radiotherapy might be effective for locally advanced esophageal carcinosarcoma: A single center’s experience and review of literature
title_full_unstemmed Intensity modulated radiotherapy might be effective for locally advanced esophageal carcinosarcoma: A single center’s experience and review of literature
title_short Intensity modulated radiotherapy might be effective for locally advanced esophageal carcinosarcoma: A single center’s experience and review of literature
title_sort intensity modulated radiotherapy might be effective for locally advanced esophageal carcinosarcoma: a single center’s experience and review of literature
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592314/
https://www.ncbi.nlm.nih.gov/pubmed/36281080
http://dx.doi.org/10.1097/MD.0000000000031215
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