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Comparison of incidence and prognosis between young and old gastric cancer patient in North-Western China: A retrospective cohort study

Gastric cancer (GC) is the fourth most common cancer in the world and the second most common cancer in China. In this study, we compared the clinicopathological features and prognosis of GC between young and old patients after curative resection. Six hundred and eighty-six patients with GC resected...

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Autores principales: An, Juan, Ma, Xiaoming, Zhang, Chengwu, Zhou, Wei, Wang, Cheng, Miao, Wei, Cai, Baojia, Yu, Pengjie, Qiao, Wenjie, Xu, Zhaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592325/
https://www.ncbi.nlm.nih.gov/pubmed/36281163
http://dx.doi.org/10.1097/MD.0000000000031255
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author An, Juan
Ma, Xiaoming
Zhang, Chengwu
Zhou, Wei
Wang, Cheng
Miao, Wei
Cai, Baojia
Yu, Pengjie
Qiao, Wenjie
Xu, Zhaojun
author_facet An, Juan
Ma, Xiaoming
Zhang, Chengwu
Zhou, Wei
Wang, Cheng
Miao, Wei
Cai, Baojia
Yu, Pengjie
Qiao, Wenjie
Xu, Zhaojun
author_sort An, Juan
collection PubMed
description Gastric cancer (GC) is the fourth most common cancer in the world and the second most common cancer in China. In this study, we compared the clinicopathological features and prognosis of GC between young and old patients after curative resection. Six hundred and eighty-six patients with GC resected were divided two groups according to patient age: Younger GC patients ≤40 years of age (YGC, n = 52) and older GC patients >40 years of age (OGC, n = 634). The YGC group had 52 (7.6%) patients in total 686 GC patients. YGC patients was predominant in women (53.8% vs 26.5%) compared with OGC patients. 5-year overall survival exhibited differences in tumor sites, tumor sizes, macroscopic types, T staging, N staging, rate of N staging (rN), tumor node metastasis staging, scope of gastrectomy, radical degree, and lymphatic vascular invasion within each of YGC and OGC group. Univariate analysis of the clinical factors affecting overall survival in YGC group revealed the significant differences in tumor size, macroscopic types (except Borrmann), T staging (except T2), N staging (N3a and N3b), rN, tumor node metastasis staging (III), scope of gastrectomy, radical degree, and lymphatic vascular invasion. Gender, N staging, rN, radical degrees were the independent prognostic factors of younger patients with GC. Similar results were found in the OGC groups. The significant differences in radical degree and lymphatic vascular invasion were found between male and female patients in YGC group. Similar results were found in the OGC groups. Our results showed that YGC patients differ from OGC patients in predominance of women. Gender, N staging, rN, radical degrees were independent risk factors for the prognosis in YGC patients.
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spelling pubmed-95923252022-10-25 Comparison of incidence and prognosis between young and old gastric cancer patient in North-Western China: A retrospective cohort study An, Juan Ma, Xiaoming Zhang, Chengwu Zhou, Wei Wang, Cheng Miao, Wei Cai, Baojia Yu, Pengjie Qiao, Wenjie Xu, Zhaojun Medicine (Baltimore) 5700 Gastric cancer (GC) is the fourth most common cancer in the world and the second most common cancer in China. In this study, we compared the clinicopathological features and prognosis of GC between young and old patients after curative resection. Six hundred and eighty-six patients with GC resected were divided two groups according to patient age: Younger GC patients ≤40 years of age (YGC, n = 52) and older GC patients >40 years of age (OGC, n = 634). The YGC group had 52 (7.6%) patients in total 686 GC patients. YGC patients was predominant in women (53.8% vs 26.5%) compared with OGC patients. 5-year overall survival exhibited differences in tumor sites, tumor sizes, macroscopic types, T staging, N staging, rate of N staging (rN), tumor node metastasis staging, scope of gastrectomy, radical degree, and lymphatic vascular invasion within each of YGC and OGC group. Univariate analysis of the clinical factors affecting overall survival in YGC group revealed the significant differences in tumor size, macroscopic types (except Borrmann), T staging (except T2), N staging (N3a and N3b), rN, tumor node metastasis staging (III), scope of gastrectomy, radical degree, and lymphatic vascular invasion. Gender, N staging, rN, radical degrees were the independent prognostic factors of younger patients with GC. Similar results were found in the OGC groups. The significant differences in radical degree and lymphatic vascular invasion were found between male and female patients in YGC group. Similar results were found in the OGC groups. Our results showed that YGC patients differ from OGC patients in predominance of women. Gender, N staging, rN, radical degrees were independent risk factors for the prognosis in YGC patients. Lippincott Williams & Wilkins 2022-10-21 /pmc/articles/PMC9592325/ /pubmed/36281163 http://dx.doi.org/10.1097/MD.0000000000031255 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle 5700
An, Juan
Ma, Xiaoming
Zhang, Chengwu
Zhou, Wei
Wang, Cheng
Miao, Wei
Cai, Baojia
Yu, Pengjie
Qiao, Wenjie
Xu, Zhaojun
Comparison of incidence and prognosis between young and old gastric cancer patient in North-Western China: A retrospective cohort study
title Comparison of incidence and prognosis between young and old gastric cancer patient in North-Western China: A retrospective cohort study
title_full Comparison of incidence and prognosis between young and old gastric cancer patient in North-Western China: A retrospective cohort study
title_fullStr Comparison of incidence and prognosis between young and old gastric cancer patient in North-Western China: A retrospective cohort study
title_full_unstemmed Comparison of incidence and prognosis between young and old gastric cancer patient in North-Western China: A retrospective cohort study
title_short Comparison of incidence and prognosis between young and old gastric cancer patient in North-Western China: A retrospective cohort study
title_sort comparison of incidence and prognosis between young and old gastric cancer patient in north-western china: a retrospective cohort study
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592325/
https://www.ncbi.nlm.nih.gov/pubmed/36281163
http://dx.doi.org/10.1097/MD.0000000000031255
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