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Clinical efficacy and safety of low-dose doxepin in Chinese patients with generalized anxiety disorder: A before–after study

Clinical and animal studies have reported that low-dose doxepin may have positive effects on generalized anxiety disorder (GAD); however, its effectiveness and clinical safety are less well understood. This study is a before-after study and aims to investigate the effectiveness and side effects of l...

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Autores principales: Zhang, Mengqi, Huang, Fengmin, Jiang, Feiyu, Mai, Meiting, Guo, Xiaorou, Zhang, Ying, Xu, Ying, Zu, Hengbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592331/
https://www.ncbi.nlm.nih.gov/pubmed/36281170
http://dx.doi.org/10.1097/MD.0000000000031201
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author Zhang, Mengqi
Huang, Fengmin
Jiang, Feiyu
Mai, Meiting
Guo, Xiaorou
Zhang, Ying
Xu, Ying
Zu, Hengbing
author_facet Zhang, Mengqi
Huang, Fengmin
Jiang, Feiyu
Mai, Meiting
Guo, Xiaorou
Zhang, Ying
Xu, Ying
Zu, Hengbing
author_sort Zhang, Mengqi
collection PubMed
description Clinical and animal studies have reported that low-dose doxepin may have positive effects on generalized anxiety disorder (GAD); however, its effectiveness and clinical safety are less well understood. This study is a before-after study and aims to investigate the effectiveness and side effects of low-dose doxepin by evaluating Hamilton Anxiety Scale (HAMA) scores, hormones, blood glucose, serum lipids, body weight, and body mass index (BMI) in patients with GAD. Forty-nine patients (20 males and 29 females) with GAD were randomly assigned to receive low-dose doxepin (6.25 mg–12.5 mg per day) for 12 weeks between February 2015 and March 2016. HAMA scores, fasting blood glucose (FBG) body weight, BMI, and some serum biochemical indexes, such as adrenocorticotropic hormone (ACTH), free triiodothyronine (FT3), total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDLC), and FBG, were assessed during pretreatment and post-treatment. Mean scores of HAMA decreased from 19.50 ± 1.22 to 8.50 ± 3.61 after low-dose doxepin treatment (P < .01). The serum levels of ACTH (4.33 ± 2.14 vs 6.12 ± 3.02 pmol/L), FT3 (4.78 ± 0.51 vs 5.15 ± 0.52 pg/mL), TC (4.55 ± 1.01 vs 5.93 ± 1.66 mmol/L), TG (1.69 ± 1.51 vs 3.39 ± 2.86 mmol/L), and LDLC (2.43 ± 0.88 vs 3.76 ± 1.25 mmol/L), and FBG (5.06 ± 0.43 vs 5.78 ± 0.81 mmol/L) were higher than that pretreatment with a significant difference (P < .01). Bodyweight (62.00 ± 7.45 vs 64.00 ± 6.44 kg, P = .23) and BMI (23.70 ± 2.35 vs 24.48 ± 2.11 kg/m(2), P = .14) had no difference after treatment. These results suggest that low-dose doxepin has beneficial clinical efficacy and safety. Low-dose doxepin can ameliorate anxiety in GAD patients and has some effects on neuroendocrine systems and the metabolic activity of serum glucose and lipid.
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spelling pubmed-95923312022-10-25 Clinical efficacy and safety of low-dose doxepin in Chinese patients with generalized anxiety disorder: A before–after study Zhang, Mengqi Huang, Fengmin Jiang, Feiyu Mai, Meiting Guo, Xiaorou Zhang, Ying Xu, Ying Zu, Hengbing Medicine (Baltimore) 5300 Clinical and animal studies have reported that low-dose doxepin may have positive effects on generalized anxiety disorder (GAD); however, its effectiveness and clinical safety are less well understood. This study is a before-after study and aims to investigate the effectiveness and side effects of low-dose doxepin by evaluating Hamilton Anxiety Scale (HAMA) scores, hormones, blood glucose, serum lipids, body weight, and body mass index (BMI) in patients with GAD. Forty-nine patients (20 males and 29 females) with GAD were randomly assigned to receive low-dose doxepin (6.25 mg–12.5 mg per day) for 12 weeks between February 2015 and March 2016. HAMA scores, fasting blood glucose (FBG) body weight, BMI, and some serum biochemical indexes, such as adrenocorticotropic hormone (ACTH), free triiodothyronine (FT3), total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDLC), and FBG, were assessed during pretreatment and post-treatment. Mean scores of HAMA decreased from 19.50 ± 1.22 to 8.50 ± 3.61 after low-dose doxepin treatment (P < .01). The serum levels of ACTH (4.33 ± 2.14 vs 6.12 ± 3.02 pmol/L), FT3 (4.78 ± 0.51 vs 5.15 ± 0.52 pg/mL), TC (4.55 ± 1.01 vs 5.93 ± 1.66 mmol/L), TG (1.69 ± 1.51 vs 3.39 ± 2.86 mmol/L), and LDLC (2.43 ± 0.88 vs 3.76 ± 1.25 mmol/L), and FBG (5.06 ± 0.43 vs 5.78 ± 0.81 mmol/L) were higher than that pretreatment with a significant difference (P < .01). Bodyweight (62.00 ± 7.45 vs 64.00 ± 6.44 kg, P = .23) and BMI (23.70 ± 2.35 vs 24.48 ± 2.11 kg/m(2), P = .14) had no difference after treatment. These results suggest that low-dose doxepin has beneficial clinical efficacy and safety. Low-dose doxepin can ameliorate anxiety in GAD patients and has some effects on neuroendocrine systems and the metabolic activity of serum glucose and lipid. Lippincott Williams & Wilkins 2022-10-21 /pmc/articles/PMC9592331/ /pubmed/36281170 http://dx.doi.org/10.1097/MD.0000000000031201 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle 5300
Zhang, Mengqi
Huang, Fengmin
Jiang, Feiyu
Mai, Meiting
Guo, Xiaorou
Zhang, Ying
Xu, Ying
Zu, Hengbing
Clinical efficacy and safety of low-dose doxepin in Chinese patients with generalized anxiety disorder: A before–after study
title Clinical efficacy and safety of low-dose doxepin in Chinese patients with generalized anxiety disorder: A before–after study
title_full Clinical efficacy and safety of low-dose doxepin in Chinese patients with generalized anxiety disorder: A before–after study
title_fullStr Clinical efficacy and safety of low-dose doxepin in Chinese patients with generalized anxiety disorder: A before–after study
title_full_unstemmed Clinical efficacy and safety of low-dose doxepin in Chinese patients with generalized anxiety disorder: A before–after study
title_short Clinical efficacy and safety of low-dose doxepin in Chinese patients with generalized anxiety disorder: A before–after study
title_sort clinical efficacy and safety of low-dose doxepin in chinese patients with generalized anxiety disorder: a before–after study
topic 5300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592331/
https://www.ncbi.nlm.nih.gov/pubmed/36281170
http://dx.doi.org/10.1097/MD.0000000000031201
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