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A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193

Human topoisomerase II beta (TOP2B) modulates DNA topology using energy from ATP hydrolysis. To investigate the conformational changes that occur during ATP hydrolysis, we determined the X-ray crystallographic structures of the human TOP2B ATPase domain bound to AMPPNP or ADP at 1.9 Å and 2.6 Å reso...

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Detalles Bibliográficos
Autores principales:	Ling, Elise M., Baslé, Arnaud, Cowell, Ian G., van den Berg, Bert, Blower, Tim R., Austin, Caroline A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592559/ https://www.ncbi.nlm.nih.gov/pubmed/35660158 http://dx.doi.org/10.1016/j.str.2022.05.009

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