Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice

Microglia are important immune cells in the central nervous system (CNS) that undergo turnover throughout the lifespan. If microglial debris is not removed in a timely manner, accumulated debris may influence CNS function. Clearance of microglial debris is crucial for CNS homeostasis. However, under...

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Detalles Bibliográficos
Autores principales: Zhou, Tian, Li, Yuxin, Li, Xiaoyu, Zeng, Fanzhuo, Rao, Yanxia, He, Yang, Wang, Yafei, Liu, Meizhen, Li, Dali, Xu, Zhen, Zhou, Xin, Du, Siling, Niu, Fugui, Peng, Jiyun, Mei, Xifan, Ji, Sheng-Jian, Shu, Yousheng, Lu, Wei, Guo, Feifan, Wu, Tianzhun, Yuan, Ti-Fei, Mao, Ying, Peng, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592609/
https://www.ncbi.nlm.nih.gov/pubmed/36280666
http://dx.doi.org/10.1038/s41467-022-33932-3

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