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Macular pigment optical density of hyperopic anisometropic amblyopic patients measured by fundus reflectometry
PURPOSE: Hyperopic anisometropia is a major cause of amblyopia and may be associated with macular pigment optical density (MPOD) reduction. To explore whether the MPOD changes in hyperopic anisometropic amblyopia, we measured the MPOD using fundus reflectometry in eyes with hyperopic anisometropic a...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592689/ https://www.ncbi.nlm.nih.gov/pubmed/36304187 http://dx.doi.org/10.3389/fmed.2022.991423 |
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author | Wang, Chenxiao Yu, Jinjin Pan, Mengmeng Ye, Xiuhong Song, E. |
author_facet | Wang, Chenxiao Yu, Jinjin Pan, Mengmeng Ye, Xiuhong Song, E. |
author_sort | Wang, Chenxiao |
collection | PubMed |
description | PURPOSE: Hyperopic anisometropia is a major cause of amblyopia and may be associated with macular pigment optical density (MPOD) reduction. To explore whether the MPOD changes in hyperopic anisometropic amblyopia, we measured the MPOD using fundus reflectometry in eyes with hyperopic anisometropic amblyopia and normal vision. METHODS: This was a cross-sectional study conducted from January 2017 to June 2017. Forty subjects (25 males and 15 females) between the ages of 6 and 10 years were recruited. The subjects' eyes were divided into two groups: amblyopic eyes (best-corrected visual acuity (BCVA) not more than 20/25 or BCVA of two eyes differing by two or more lines) and fellow eyes. All enrolled subjects underwent a comprehensive ophthalmic examination, including extraocular motility assessment, cover-uncover testing, and refractive error (noncycloplegic), BCVA, axial length (AL), macular foveal thickness (MFT) and MPOD (Visucam(®) 200, Carl Zeiss Meditec AG, Germany). RESULTS: The MPOD of amblyopic and fellow eyes was 0.12 ± 0.03 log units and 0.13 ± 0.04 log units, respectively, with a significant difference (P = 0.026). The MFT of amblyopic and fellow eyes was 241.28 ± 13.95 and 237.13 ± 16.02 μm, respectively, revealing that the MFT was significantly higher in amblyopic eyes than in fellow eyes (P = 0.028). Conversely, there was no correlation between the MPOD and MFT in the two groups. CONCLUSIONS: This study is the first to report that the MPOD is decreased in hyperopic anisometropic amblyopia. In this study, no correlation between the MPOD and MFT was found. In the future, factors that induce a decrease in the MPOD in eyes with hyperopic anisometropic amblyopia should be explored in a large-sample study with follow-up observation. |
format | Online Article Text |
id | pubmed-9592689 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95926892022-10-26 Macular pigment optical density of hyperopic anisometropic amblyopic patients measured by fundus reflectometry Wang, Chenxiao Yu, Jinjin Pan, Mengmeng Ye, Xiuhong Song, E. Front Med (Lausanne) Medicine PURPOSE: Hyperopic anisometropia is a major cause of amblyopia and may be associated with macular pigment optical density (MPOD) reduction. To explore whether the MPOD changes in hyperopic anisometropic amblyopia, we measured the MPOD using fundus reflectometry in eyes with hyperopic anisometropic amblyopia and normal vision. METHODS: This was a cross-sectional study conducted from January 2017 to June 2017. Forty subjects (25 males and 15 females) between the ages of 6 and 10 years were recruited. The subjects' eyes were divided into two groups: amblyopic eyes (best-corrected visual acuity (BCVA) not more than 20/25 or BCVA of two eyes differing by two or more lines) and fellow eyes. All enrolled subjects underwent a comprehensive ophthalmic examination, including extraocular motility assessment, cover-uncover testing, and refractive error (noncycloplegic), BCVA, axial length (AL), macular foveal thickness (MFT) and MPOD (Visucam(®) 200, Carl Zeiss Meditec AG, Germany). RESULTS: The MPOD of amblyopic and fellow eyes was 0.12 ± 0.03 log units and 0.13 ± 0.04 log units, respectively, with a significant difference (P = 0.026). The MFT of amblyopic and fellow eyes was 241.28 ± 13.95 and 237.13 ± 16.02 μm, respectively, revealing that the MFT was significantly higher in amblyopic eyes than in fellow eyes (P = 0.028). Conversely, there was no correlation between the MPOD and MFT in the two groups. CONCLUSIONS: This study is the first to report that the MPOD is decreased in hyperopic anisometropic amblyopia. In this study, no correlation between the MPOD and MFT was found. In the future, factors that induce a decrease in the MPOD in eyes with hyperopic anisometropic amblyopia should be explored in a large-sample study with follow-up observation. Frontiers Media S.A. 2022-10-11 /pmc/articles/PMC9592689/ /pubmed/36304187 http://dx.doi.org/10.3389/fmed.2022.991423 Text en Copyright © 2022 Wang, Yu, Pan, Ye and Song. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Wang, Chenxiao Yu, Jinjin Pan, Mengmeng Ye, Xiuhong Song, E. Macular pigment optical density of hyperopic anisometropic amblyopic patients measured by fundus reflectometry |
title | Macular pigment optical density of hyperopic anisometropic amblyopic patients measured by fundus reflectometry |
title_full | Macular pigment optical density of hyperopic anisometropic amblyopic patients measured by fundus reflectometry |
title_fullStr | Macular pigment optical density of hyperopic anisometropic amblyopic patients measured by fundus reflectometry |
title_full_unstemmed | Macular pigment optical density of hyperopic anisometropic amblyopic patients measured by fundus reflectometry |
title_short | Macular pigment optical density of hyperopic anisometropic amblyopic patients measured by fundus reflectometry |
title_sort | macular pigment optical density of hyperopic anisometropic amblyopic patients measured by fundus reflectometry |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592689/ https://www.ncbi.nlm.nih.gov/pubmed/36304187 http://dx.doi.org/10.3389/fmed.2022.991423 |
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