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Small airway dysfunction in idiopathic pulmonary fibrosis

It is generally accepted that the pathophysiology of idiopathic pulmonary fibrosis (IPF) can be attributed to impaired lung interstitium and alveoli, while airway involvement has rarely been reported. In the present study, we aimed to investigate the actual occurrence of IPF comorbid small airway dy...

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Autores principales: Yin, Chengsheng, Xie, Huikang, He, Xian, Zhang, Yuan, Zhang, Aihong, Li, Huiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592693/
https://www.ncbi.nlm.nih.gov/pubmed/36304160
http://dx.doi.org/10.3389/fphar.2022.1025814
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author Yin, Chengsheng
Xie, Huikang
He, Xian
Zhang, Yuan
Zhang, Aihong
Li, Huiping
author_facet Yin, Chengsheng
Xie, Huikang
He, Xian
Zhang, Yuan
Zhang, Aihong
Li, Huiping
author_sort Yin, Chengsheng
collection PubMed
description It is generally accepted that the pathophysiology of idiopathic pulmonary fibrosis (IPF) can be attributed to impaired lung interstitium and alveoli, while airway involvement has rarely been reported. In the present study, we aimed to investigate the actual occurrence of IPF comorbid small airway dysfunction (SAD) and its impact on survival. Data from inpatients diagnosed with IPF at Shanghai Pulmonary Hospital (Shanghai, China) from 2011 to 2021 were retrospectively collected and analyzed. Lung function parameters were used to assess SAD. A total of 243 IPF patients were included in this retrospective study, and 84 cases (84/243, 34.57%) were diagnosed with SAD. The lung histopathology showed that all 48 cases undergoing lung transplantation presented various degrees of airway lesions, of which 18 patients (18/48, 37.5%) diagnosed with SAD before lung transplantation had a higher proportion of airway distortion and obliteration. The possible risk factors associated with IPF comorbid SAD were smoking, male, younger age, and high CT fibrosis and emphysema scores. By univariate Fine-Grey regression, the hazard ratio (HR) of IPF comorbid SAD was 1.725 (95% CI 1.071, 2.777, p < 0.05). After adjusting the CTPF model and GAP model, the value of HR was 1.714 (95% CI 1.043, 2.816, p < 0.05) and 1.731 (95% CI 1.074, 2.788, p < 0.05), respectively. These findings suggested that IPF comorbid SAD was an independent risk factor for the mortality of IPF patients.
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spelling pubmed-95926932022-10-26 Small airway dysfunction in idiopathic pulmonary fibrosis Yin, Chengsheng Xie, Huikang He, Xian Zhang, Yuan Zhang, Aihong Li, Huiping Front Pharmacol Pharmacology It is generally accepted that the pathophysiology of idiopathic pulmonary fibrosis (IPF) can be attributed to impaired lung interstitium and alveoli, while airway involvement has rarely been reported. In the present study, we aimed to investigate the actual occurrence of IPF comorbid small airway dysfunction (SAD) and its impact on survival. Data from inpatients diagnosed with IPF at Shanghai Pulmonary Hospital (Shanghai, China) from 2011 to 2021 were retrospectively collected and analyzed. Lung function parameters were used to assess SAD. A total of 243 IPF patients were included in this retrospective study, and 84 cases (84/243, 34.57%) were diagnosed with SAD. The lung histopathology showed that all 48 cases undergoing lung transplantation presented various degrees of airway lesions, of which 18 patients (18/48, 37.5%) diagnosed with SAD before lung transplantation had a higher proportion of airway distortion and obliteration. The possible risk factors associated with IPF comorbid SAD were smoking, male, younger age, and high CT fibrosis and emphysema scores. By univariate Fine-Grey regression, the hazard ratio (HR) of IPF comorbid SAD was 1.725 (95% CI 1.071, 2.777, p < 0.05). After adjusting the CTPF model and GAP model, the value of HR was 1.714 (95% CI 1.043, 2.816, p < 0.05) and 1.731 (95% CI 1.074, 2.788, p < 0.05), respectively. These findings suggested that IPF comorbid SAD was an independent risk factor for the mortality of IPF patients. Frontiers Media S.A. 2022-10-11 /pmc/articles/PMC9592693/ /pubmed/36304160 http://dx.doi.org/10.3389/fphar.2022.1025814 Text en Copyright © 2022 Yin, Xie, He, Zhang, Zhang and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Yin, Chengsheng
Xie, Huikang
He, Xian
Zhang, Yuan
Zhang, Aihong
Li, Huiping
Small airway dysfunction in idiopathic pulmonary fibrosis
title Small airway dysfunction in idiopathic pulmonary fibrosis
title_full Small airway dysfunction in idiopathic pulmonary fibrosis
title_fullStr Small airway dysfunction in idiopathic pulmonary fibrosis
title_full_unstemmed Small airway dysfunction in idiopathic pulmonary fibrosis
title_short Small airway dysfunction in idiopathic pulmonary fibrosis
title_sort small airway dysfunction in idiopathic pulmonary fibrosis
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592693/
https://www.ncbi.nlm.nih.gov/pubmed/36304160
http://dx.doi.org/10.3389/fphar.2022.1025814
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