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Cinnamaldehyde-modified chitosan hybrid nanoparticles for DOX delivering to produce synergistic anti-tumor effects

Cancer cells are under oxidative stress associated with the increased generation of reactive oxygen species (ROS). Therefore, increasing the oxidative stress of tumor cells by delivering ROS generators is an effective strategy to induce apoptosis of cancer cells. Herein, we reported a hybrid nanopar...

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Detalles Bibliográficos
Autores principales: Zhou, Zuoqin, Wang, Caiyun, Bai, Jingqi, Zeng, Zihan, Yang, Xiaoyu, Wei, Bing, Yang, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592695/
https://www.ncbi.nlm.nih.gov/pubmed/36304902
http://dx.doi.org/10.3389/fbioe.2022.968065
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author Zhou, Zuoqin
Wang, Caiyun
Bai, Jingqi
Zeng, Zihan
Yang, Xiaoyu
Wei, Bing
Yang, Zheng
author_facet Zhou, Zuoqin
Wang, Caiyun
Bai, Jingqi
Zeng, Zihan
Yang, Xiaoyu
Wei, Bing
Yang, Zheng
author_sort Zhou, Zuoqin
collection PubMed
description Cancer cells are under oxidative stress associated with the increased generation of reactive oxygen species (ROS). Therefore, increasing the oxidative stress of tumor cells by delivering ROS generators is an effective strategy to induce apoptosis of cancer cells. Herein, we reported a hybrid nanoparticle based on lactobionic acid (LA) modified chitosan and cinnamaldehyde (CA) modified chitosan, which possesses both active tumor-targeting ability and ROS regulation ability, in order to have a synergistic effect with the anti-tumor drug doxorubicin (DOX). LA can improve the tumor-targeting ability and cellular accumulation of these nanoparticles, and CA can induce apoptotic cell death through ROS generation, mitochondrial permeability transition and caspase activation. The particle size and distribution as well as drug release profiles of these nanoparticles were observed. In vitro and in vivo antitumor studies demonstrated that the hybrid nanoparticles show a significant synergistic antitumor effect. Thus, we anticipate that the hybrid nanoparticles have promising potential as an anticancer drug carrier.
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spelling pubmed-95926952022-10-26 Cinnamaldehyde-modified chitosan hybrid nanoparticles for DOX delivering to produce synergistic anti-tumor effects Zhou, Zuoqin Wang, Caiyun Bai, Jingqi Zeng, Zihan Yang, Xiaoyu Wei, Bing Yang, Zheng Front Bioeng Biotechnol Bioengineering and Biotechnology Cancer cells are under oxidative stress associated with the increased generation of reactive oxygen species (ROS). Therefore, increasing the oxidative stress of tumor cells by delivering ROS generators is an effective strategy to induce apoptosis of cancer cells. Herein, we reported a hybrid nanoparticle based on lactobionic acid (LA) modified chitosan and cinnamaldehyde (CA) modified chitosan, which possesses both active tumor-targeting ability and ROS regulation ability, in order to have a synergistic effect with the anti-tumor drug doxorubicin (DOX). LA can improve the tumor-targeting ability and cellular accumulation of these nanoparticles, and CA can induce apoptotic cell death through ROS generation, mitochondrial permeability transition and caspase activation. The particle size and distribution as well as drug release profiles of these nanoparticles were observed. In vitro and in vivo antitumor studies demonstrated that the hybrid nanoparticles show a significant synergistic antitumor effect. Thus, we anticipate that the hybrid nanoparticles have promising potential as an anticancer drug carrier. Frontiers Media S.A. 2022-10-11 /pmc/articles/PMC9592695/ /pubmed/36304902 http://dx.doi.org/10.3389/fbioe.2022.968065 Text en Copyright © 2022 Zhou, Wang, Bai, Zeng, Yang, Wei and Yang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Zhou, Zuoqin
Wang, Caiyun
Bai, Jingqi
Zeng, Zihan
Yang, Xiaoyu
Wei, Bing
Yang, Zheng
Cinnamaldehyde-modified chitosan hybrid nanoparticles for DOX delivering to produce synergistic anti-tumor effects
title Cinnamaldehyde-modified chitosan hybrid nanoparticles for DOX delivering to produce synergistic anti-tumor effects
title_full Cinnamaldehyde-modified chitosan hybrid nanoparticles for DOX delivering to produce synergistic anti-tumor effects
title_fullStr Cinnamaldehyde-modified chitosan hybrid nanoparticles for DOX delivering to produce synergistic anti-tumor effects
title_full_unstemmed Cinnamaldehyde-modified chitosan hybrid nanoparticles for DOX delivering to produce synergistic anti-tumor effects
title_short Cinnamaldehyde-modified chitosan hybrid nanoparticles for DOX delivering to produce synergistic anti-tumor effects
title_sort cinnamaldehyde-modified chitosan hybrid nanoparticles for dox delivering to produce synergistic anti-tumor effects
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592695/
https://www.ncbi.nlm.nih.gov/pubmed/36304902
http://dx.doi.org/10.3389/fbioe.2022.968065
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