The protective roles of augmenter of liver regeneration in hepatocytes in the non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) occurs in 25% of the global population and manifests as lipid deposition, hepatocyte injury, activation of Kupffer and stellate cells, and steatohepatitis. Predominantly expressed in hepatocytes, the augmenter of liver regeneration (ALR) is a key factor in l...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592723/ https://www.ncbi.nlm.nih.gov/pubmed/36304168 http://dx.doi.org/10.3389/fphar.2022.928606 |
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author | Dong, Yuan Zhang, Yuejie Feng, Yingmei An, Wei |
author_facet | Dong, Yuan Zhang, Yuejie Feng, Yingmei An, Wei |
author_sort | Dong, Yuan |
collection | PubMed |
description | Non-alcoholic fatty liver disease (NAFLD) occurs in 25% of the global population and manifests as lipid deposition, hepatocyte injury, activation of Kupffer and stellate cells, and steatohepatitis. Predominantly expressed in hepatocytes, the augmenter of liver regeneration (ALR) is a key factor in liver regulation that can alleviate fatty liver disease and protect the liver from abnormal liver lipid metabolism. ALR has three isoforms (15-, 21-, and 23-kDa), amongst which 23-kDa ALR is the most extensively studied. The 23-kDa ALR isoform is a sulfhydryl oxidase that resides primarily in the mitochondrial intermembrane space (IMS), whereby it protects the liver against various types of injury. In this review, we describe the role of ALR in regulating hepatocytes in the context of NAFLD. We also discuss questions about ALR that remain to be explored in the future. In conclusion, ALR appears to be a promising therapeutic target for treating NAFLD. |
format | Online Article Text |
id | pubmed-9592723 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95927232022-10-26 The protective roles of augmenter of liver regeneration in hepatocytes in the non-alcoholic fatty liver disease Dong, Yuan Zhang, Yuejie Feng, Yingmei An, Wei Front Pharmacol Pharmacology Non-alcoholic fatty liver disease (NAFLD) occurs in 25% of the global population and manifests as lipid deposition, hepatocyte injury, activation of Kupffer and stellate cells, and steatohepatitis. Predominantly expressed in hepatocytes, the augmenter of liver regeneration (ALR) is a key factor in liver regulation that can alleviate fatty liver disease and protect the liver from abnormal liver lipid metabolism. ALR has three isoforms (15-, 21-, and 23-kDa), amongst which 23-kDa ALR is the most extensively studied. The 23-kDa ALR isoform is a sulfhydryl oxidase that resides primarily in the mitochondrial intermembrane space (IMS), whereby it protects the liver against various types of injury. In this review, we describe the role of ALR in regulating hepatocytes in the context of NAFLD. We also discuss questions about ALR that remain to be explored in the future. In conclusion, ALR appears to be a promising therapeutic target for treating NAFLD. Frontiers Media S.A. 2022-10-11 /pmc/articles/PMC9592723/ /pubmed/36304168 http://dx.doi.org/10.3389/fphar.2022.928606 Text en Copyright © 2022 Dong, Zhang, Feng and An. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Dong, Yuan Zhang, Yuejie Feng, Yingmei An, Wei The protective roles of augmenter of liver regeneration in hepatocytes in the non-alcoholic fatty liver disease |
title | The protective roles of augmenter of liver regeneration in hepatocytes in the non-alcoholic fatty liver disease |
title_full | The protective roles of augmenter of liver regeneration in hepatocytes in the non-alcoholic fatty liver disease |
title_fullStr | The protective roles of augmenter of liver regeneration in hepatocytes in the non-alcoholic fatty liver disease |
title_full_unstemmed | The protective roles of augmenter of liver regeneration in hepatocytes in the non-alcoholic fatty liver disease |
title_short | The protective roles of augmenter of liver regeneration in hepatocytes in the non-alcoholic fatty liver disease |
title_sort | protective roles of augmenter of liver regeneration in hepatocytes in the non-alcoholic fatty liver disease |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592723/ https://www.ncbi.nlm.nih.gov/pubmed/36304168 http://dx.doi.org/10.3389/fphar.2022.928606 |
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