The protective roles of augmenter of liver regeneration in hepatocytes in the non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD) occurs in 25% of the global population and manifests as lipid deposition, hepatocyte injury, activation of Kupffer and stellate cells, and steatohepatitis. Predominantly expressed in hepatocytes, the augmenter of liver regeneration (ALR) is a key factor in l...

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Autores principales: Dong, Yuan, Zhang, Yuejie, Feng, Yingmei, An, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592723/
https://www.ncbi.nlm.nih.gov/pubmed/36304168
http://dx.doi.org/10.3389/fphar.2022.928606
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author Dong, Yuan
Zhang, Yuejie
Feng, Yingmei
An, Wei
author_facet Dong, Yuan
Zhang, Yuejie
Feng, Yingmei
An, Wei
author_sort Dong, Yuan
collection PubMed
description Non-alcoholic fatty liver disease (NAFLD) occurs in 25% of the global population and manifests as lipid deposition, hepatocyte injury, activation of Kupffer and stellate cells, and steatohepatitis. Predominantly expressed in hepatocytes, the augmenter of liver regeneration (ALR) is a key factor in liver regulation that can alleviate fatty liver disease and protect the liver from abnormal liver lipid metabolism. ALR has three isoforms (15-, 21-, and 23-kDa), amongst which 23-kDa ALR is the most extensively studied. The 23-kDa ALR isoform is a sulfhydryl oxidase that resides primarily in the mitochondrial intermembrane space (IMS), whereby it protects the liver against various types of injury. In this review, we describe the role of ALR in regulating hepatocytes in the context of NAFLD. We also discuss questions about ALR that remain to be explored in the future. In conclusion, ALR appears to be a promising therapeutic target for treating NAFLD.
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spelling pubmed-95927232022-10-26 The protective roles of augmenter of liver regeneration in hepatocytes in the non-alcoholic fatty liver disease Dong, Yuan Zhang, Yuejie Feng, Yingmei An, Wei Front Pharmacol Pharmacology Non-alcoholic fatty liver disease (NAFLD) occurs in 25% of the global population and manifests as lipid deposition, hepatocyte injury, activation of Kupffer and stellate cells, and steatohepatitis. Predominantly expressed in hepatocytes, the augmenter of liver regeneration (ALR) is a key factor in liver regulation that can alleviate fatty liver disease and protect the liver from abnormal liver lipid metabolism. ALR has three isoforms (15-, 21-, and 23-kDa), amongst which 23-kDa ALR is the most extensively studied. The 23-kDa ALR isoform is a sulfhydryl oxidase that resides primarily in the mitochondrial intermembrane space (IMS), whereby it protects the liver against various types of injury. In this review, we describe the role of ALR in regulating hepatocytes in the context of NAFLD. We also discuss questions about ALR that remain to be explored in the future. In conclusion, ALR appears to be a promising therapeutic target for treating NAFLD. Frontiers Media S.A. 2022-10-11 /pmc/articles/PMC9592723/ /pubmed/36304168 http://dx.doi.org/10.3389/fphar.2022.928606 Text en Copyright © 2022 Dong, Zhang, Feng and An. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Dong, Yuan
Zhang, Yuejie
Feng, Yingmei
An, Wei
The protective roles of augmenter of liver regeneration in hepatocytes in the non-alcoholic fatty liver disease
title The protective roles of augmenter of liver regeneration in hepatocytes in the non-alcoholic fatty liver disease
title_full The protective roles of augmenter of liver regeneration in hepatocytes in the non-alcoholic fatty liver disease
title_fullStr The protective roles of augmenter of liver regeneration in hepatocytes in the non-alcoholic fatty liver disease
title_full_unstemmed The protective roles of augmenter of liver regeneration in hepatocytes in the non-alcoholic fatty liver disease
title_short The protective roles of augmenter of liver regeneration in hepatocytes in the non-alcoholic fatty liver disease
title_sort protective roles of augmenter of liver regeneration in hepatocytes in the non-alcoholic fatty liver disease
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592723/
https://www.ncbi.nlm.nih.gov/pubmed/36304168
http://dx.doi.org/10.3389/fphar.2022.928606
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