Cargando…

Population‐based meta‐analysis and gene‐set enrichment identifies FXR/RXR pathway as common to fatty liver disease and serum lipids

Nonalcoholic fatty liver disease (NAFLD) is prevalent worldwide. NAFLD is associated with elevated serum triglycerides (TG), low‐density lipoprotein cholesterol (LDL), and reduced high‐density lipoprotein cholesterol (HDL). Both NAFLD and blood lipid levels are genetically influenced and may share a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Handelman, Samuel K., Puentes, Yindra M., Kuppa, Annapurna, Chen, Yanhua, Du, Xiaomeng, Feitosa, Mary F., Palmer, Nicholette D., Speliotes, Elizabeth K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592792/ https://www.ncbi.nlm.nih.gov/pubmed/36098472 http://dx.doi.org/10.1002/hep4.2066

Ejemplares similares

Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology
por: Chen, Vincent L., et al.
Publicado: (2021)

Author Correction: Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology
por: Chen, Vincent L., et al.
Publicado: (2023)

Perturbation of TM6SF2 Expression Alters Lipid Metabolism in a Human Liver Cell Line
por: Pant, Asmita, et al.
Publicado: (2021)

Body Composition and Genetic Lipodystrophy Risk Score Associate With Nonalcoholic Fatty Liver Disease and Liver Fibrosis
por: Chen, Vincent L., et al.
Publicado: (2019)

Quantitative proteomic study of the plasma reveals acute phase response and LXR/RXR and FXR/RXR activation in the chronic unpredictable mild stress mouse model of depression
por: Yang, Chuangchuang, et al.
Publicado: (2018)

Multi-Omics Analysis Reveals Up-Regulation of APR Signaling, LXR/RXR and FXR/RXR Activation Pathways in Holstein Dairy Cows Exposed to High-Altitude Hypoxia
por: Kong, Zhiwei, et al.
Publicado: (2019)

Genome-wide association analyses identify 39 new susceptibility loci for diverticular disease
por: Maguire, Lillias H., et al.
Publicado: (2018)

RAR/RXR and PPAR/RXR Signaling in Spinal Cord Injury
por: van Neerven, Sabien, et al.
Publicado: (2007)

Fatty liver diseases, bile acids, and FXR
por: Zhu, Yan, et al.
Publicado: (2016)

Celastrol-regulated gut microbiota and bile acid metabolism alleviate hepatocellular carcinoma proliferation by regulating the interaction between FXR and RXRα in vivo and in vitro
por: Zeng, Dequan, et al.
Publicado: (2023)

Regulation of RXR-RAR Heterodimers by RXR- and RAR-Specific Ligands and Their Combinations
por: le Maire, Albane, et al.
Publicado: (2019)

Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism
por: Correia, Jorge C., et al.
Publicado: (2015)

Risk of Alcohol Abuse in Humans with Attention-deficit/Hyperactivity Disorder Symptoms
por: Kuppa, Annapurna, et al.
Publicado: (2019)

Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization
por: Scheepstra, Marcel, et al.
Publicado: (2017)

Homology modeling and global computational mutagenesis of human myosin VIIa
por: Kuppa, Annapurna, et al.
Publicado: (2021)

Analysis of RXR/THR and RXR/PPARG2 Heterodimerization by Bioluminescence Resonance Energy Transfer (BRET)
por: Mulero, Miquel, et al.
Publicado: (2013)

Farnesoid X Receptor (FXR) Activation and FXR Genetic Variation in Inflammatory Bowel Disease
por: Nijmeijer, Rian M., et al.
Publicado: (2011)

Investigating the Role Intestinal-Specific FXR and SHP in Regulating Lipid Metabolism in Mice
por: Nguyen, James ThienToan, et al.
Publicado: (2021)

RXR Ligands Negatively Regulate Thrombosis and Hemostasis
por: Unsworth, Amanda J., et al.
Publicado: (2017)

PPAR/RXR Regulation of Fatty Acid Metabolism and Fatty Acid ω-Hydroxylase (CYP4) Isozymes: Implications for Prevention of Lipotoxicity in Fatty Liver Disease
por: Hardwick, James P., et al.
Publicado: (2009)

Reconstruction of FXR Beam Conditions
por: Nexsen, W E, et al.
Publicado: (2001)

Chlorogenic Acid Inhibits Lipid Deposition by Regulating the Enterohepatic FXR-FGF15 Pathway
por: Ye, Xiaolin, et al.
Publicado: (2022)

Molecular Evolution of Ultraspiracle Protein (USP/RXR) in Insects
por: Hult, Ekaterina F., et al.
Publicado: (2011)

RXRα Regulates the Development of Resident Tissue Macrophages
por: Philpott, Jordan, et al.
Publicado: (2022)

The Effects of PPAR Agonists on Atherosclerosis and Nonalcoholic Fatty Liver Disease in ApoE(−/−)FXR(−/−) Mice
por: Lee, Yenna, et al.
Publicado: (2021)

SIRT1 activation synergizes with FXR agonism in hepatoprotection via governing nucleocytoplasmic shuttling and degradation of FXR
por: Cui, Shuang, et al.
Publicado: (2023)

Insulin Resistance Exacerbates Genetic Predisposition to Nonalcoholic Fatty Liver Disease in Individuals Without Diabetes
por: Barata, Llilda, et al.
Publicado: (2019)

FXR expression is associated with dysregulated glucose and lipid levels in the offspring kidney induced by maternal obesity
por: Glastras, Sarah J., et al.
Publicado: (2015)

Microsecond MD Simulations to Explore the Structural and Energetic Differences between the Human RXRα-PPARγ vs. RXRα-PPARγ-DNA
por: Azam, Faizul, et al.
Publicado: (2022)

Mysterious Mechanisms of Memory Formation: Are the Answers Hidden in Synapses?
por: Joshi, Viraj V, et al.
Publicado: (2019)

FXR controls CHOP expression in steatohepatitis
por: Fuchs, Claudia D., et al.
Publicado: (2017)

FXR expression in rats of hilar cholangiocarcinoma
por: Zhang, Meng-yu, et al.
Publicado: (2022)

Impact of Global Fxr Deficiency on Experimental Acute Pancreatitis and Genetic Variation in the FXR Locus in Human Acute Pancreatitis
por: Nijmeijer, Rian M., et al.
Publicado: (2014)

Selective targeting of nuclear receptor FXR by avermectin analogues with therapeutic effects on nonalcoholic fatty liver disease
por: Jin, Lihua, et al.
Publicado: (2015)

Effects of cholesterol-lowering probiotics on non-alcoholic fatty liver disease in FXR gene knockout mice
por: Yang, Minghua, et al.
Publicado: (2023)

Solution Structures of PPARγ2/RXRα Complexes
por: Osz, Judit, et al.
Publicado: (2012)

Structural mechanism for signal transduction in RXR nuclear receptor heterodimers
por: Kojetin, Douglas J., et al.
Publicado: (2015)

RXR Expression in Marine Gastropods with Different Sensitivity to Imposex Development
por: Giulianelli, Sebastián, et al.
Publicado: (2020)

Cytoplasmic Localization of RXRα Determines Outcome in Breast Cancer
por: Zati zehni, Alaleh, et al.
Publicado: (2021)

Bile acids mediated potential functional interaction between FXR and FATP5 in the regulation of Lipid Metabolism
por: Kumari, Anita, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_v8mqggnbqnuu6ke2ooto45sq5h