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Influence of early fluid overload on bronchopulmonary dysplasia in very low-birth-weight infants

OBJECTIVE: This study aimed to determine the influence of fluid overload on bronchopulmonary dysplasia (BPD) in very low-birth-weight infants (VLBWI) within 1 week after birth. METHODS: This was a retrospective case control study conducted in the Jingzhou Central Hospital. The clinical data of VLBWI...

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Autores principales: Li, Yu-Jie, Zhu, Xiao-Fang, Liu, Jian-Hong, Yi, Xiao-Qian, He, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592840/
https://www.ncbi.nlm.nih.gov/pubmed/36304527
http://dx.doi.org/10.3389/fped.2022.980179
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author Li, Yu-Jie
Zhu, Xiao-Fang
Liu, Jian-Hong
Yi, Xiao-Qian
He, Hao
author_facet Li, Yu-Jie
Zhu, Xiao-Fang
Liu, Jian-Hong
Yi, Xiao-Qian
He, Hao
author_sort Li, Yu-Jie
collection PubMed
description OBJECTIVE: This study aimed to determine the influence of fluid overload on bronchopulmonary dysplasia (BPD) in very low-birth-weight infants (VLBWI) within 1 week after birth. METHODS: This was a retrospective case control study conducted in the Jingzhou Central Hospital. The clinical data of VLBWI (with a birth weight [BW] < 1,500 g and 26 weeks ≤ gestational age [GA] < 32 weeks) who were admitted to the neonatal intensive care unit of this hospital from January 2016 to December 2021 were analyzed retrospectively. A total of 157 cases were enrolled and divided into a BPD group (n = 60) and a non-BPD group (n = 97) according to whether BPD was present. The general condition, fluid intake, and fluid overload of the two groups of neonates within 1 week after birth were compared. The logistic regression was used to assess the association between infant characteristics and BPD. The ROC curve was used to assess how well the 7 day cumulative fluid overload predicted BPD, and to identify an optimal cut off for prediction. RESULTS: The comparison of the patients' general condition revealed that the neonates in the BPD group had a younger GA, lower BW, lower 5-min Apgar score, longer duration of invasive mechanical ventilation, and higher incidence of intrauterine infections and administration of surfactants (P < 0.05). The differences in the other indicators were not statistically significant between the two groups. The logistic regression analysis revealed that a younger GA, the presence of intrauterine infection, and a 7-day cumulative fluid overload were the risk factors for the development of BPD. A ROC curve was plotted with the 7-day cumulative fluid overload as the test variable and BPD as the status variable. The area under the curve was 0.75 (95% confidence interval: 0.664–0.826, P = 0.042), with a sensitivity of 76.7% and a specificity of 70.1%, corresponding to a 7-day cumulative fluid overload of 36.2%. CONCLUSION: A younger GA, the presence of intrauterine infection, and a 7-day cumulative fluid overload were risk factors for the development of BPD. A 7 day cumulative fluid overload threshold of 36.2% best predicted the development of BPD.
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spelling pubmed-95928402022-10-26 Influence of early fluid overload on bronchopulmonary dysplasia in very low-birth-weight infants Li, Yu-Jie Zhu, Xiao-Fang Liu, Jian-Hong Yi, Xiao-Qian He, Hao Front Pediatr Pediatrics OBJECTIVE: This study aimed to determine the influence of fluid overload on bronchopulmonary dysplasia (BPD) in very low-birth-weight infants (VLBWI) within 1 week after birth. METHODS: This was a retrospective case control study conducted in the Jingzhou Central Hospital. The clinical data of VLBWI (with a birth weight [BW] < 1,500 g and 26 weeks ≤ gestational age [GA] < 32 weeks) who were admitted to the neonatal intensive care unit of this hospital from January 2016 to December 2021 were analyzed retrospectively. A total of 157 cases were enrolled and divided into a BPD group (n = 60) and a non-BPD group (n = 97) according to whether BPD was present. The general condition, fluid intake, and fluid overload of the two groups of neonates within 1 week after birth were compared. The logistic regression was used to assess the association between infant characteristics and BPD. The ROC curve was used to assess how well the 7 day cumulative fluid overload predicted BPD, and to identify an optimal cut off for prediction. RESULTS: The comparison of the patients' general condition revealed that the neonates in the BPD group had a younger GA, lower BW, lower 5-min Apgar score, longer duration of invasive mechanical ventilation, and higher incidence of intrauterine infections and administration of surfactants (P < 0.05). The differences in the other indicators were not statistically significant between the two groups. The logistic regression analysis revealed that a younger GA, the presence of intrauterine infection, and a 7-day cumulative fluid overload were the risk factors for the development of BPD. A ROC curve was plotted with the 7-day cumulative fluid overload as the test variable and BPD as the status variable. The area under the curve was 0.75 (95% confidence interval: 0.664–0.826, P = 0.042), with a sensitivity of 76.7% and a specificity of 70.1%, corresponding to a 7-day cumulative fluid overload of 36.2%. CONCLUSION: A younger GA, the presence of intrauterine infection, and a 7-day cumulative fluid overload were risk factors for the development of BPD. A 7 day cumulative fluid overload threshold of 36.2% best predicted the development of BPD. Frontiers Media S.A. 2022-10-11 /pmc/articles/PMC9592840/ /pubmed/36304527 http://dx.doi.org/10.3389/fped.2022.980179 Text en Copyright © 2022 Li, Zhu, Liu, Yi and He. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Li, Yu-Jie
Zhu, Xiao-Fang
Liu, Jian-Hong
Yi, Xiao-Qian
He, Hao
Influence of early fluid overload on bronchopulmonary dysplasia in very low-birth-weight infants
title Influence of early fluid overload on bronchopulmonary dysplasia in very low-birth-weight infants
title_full Influence of early fluid overload on bronchopulmonary dysplasia in very low-birth-weight infants
title_fullStr Influence of early fluid overload on bronchopulmonary dysplasia in very low-birth-weight infants
title_full_unstemmed Influence of early fluid overload on bronchopulmonary dysplasia in very low-birth-weight infants
title_short Influence of early fluid overload on bronchopulmonary dysplasia in very low-birth-weight infants
title_sort influence of early fluid overload on bronchopulmonary dysplasia in very low-birth-weight infants
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592840/
https://www.ncbi.nlm.nih.gov/pubmed/36304527
http://dx.doi.org/10.3389/fped.2022.980179
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