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Soluble guanylyl cyclase: Molecular basis for ligand selectivity and action in vitro and in vivo

Nitric oxide (NO), carbon monoxide (CO), oxygen (O(2)), hydrogen sulfide (H(2)S) are gaseous molecules that play important roles in the physiology and pathophysiology of eukaryotes. Tissue concentrations of these physiologically relevant gases vary remarkable from nM range for NO to high μM range of...

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Autores principales: Wu, Gang, Sharina, Iraida, Martin, Emil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592903/
https://www.ncbi.nlm.nih.gov/pubmed/36304925
http://dx.doi.org/10.3389/fmolb.2022.1007768
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author Wu, Gang
Sharina, Iraida
Martin, Emil
author_facet Wu, Gang
Sharina, Iraida
Martin, Emil
author_sort Wu, Gang
collection PubMed
description Nitric oxide (NO), carbon monoxide (CO), oxygen (O(2)), hydrogen sulfide (H(2)S) are gaseous molecules that play important roles in the physiology and pathophysiology of eukaryotes. Tissue concentrations of these physiologically relevant gases vary remarkable from nM range for NO to high μM range of O(2). Various hemoproteins play a significant role in sensing and transducing cellular signals encoded by gaseous molecules or in transporting them. Soluble guanylyl cyclase (sGC) is a hemoprotein that plays vital roles in a wide range of physiological functions and combines the functions of gaseous sensor and signal transducer. sGC uniquely evolved to sense low non-toxic levels of NO and respond to elevated NO levels by increasing its catalytic ability to generate the secondary signaling messenger cyclic guanosine monophosphate (cGMP). This review discusses sGC’s gaseous ligand selectivity and the molecular basis for sGC function as high-affinity and selectivity NO receptor. The effects of other gaseous molecules and small molecules of cellular origin on sGC’s function are also discussed.
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spelling pubmed-95929032022-10-26 Soluble guanylyl cyclase: Molecular basis for ligand selectivity and action in vitro and in vivo Wu, Gang Sharina, Iraida Martin, Emil Front Mol Biosci Molecular Biosciences Nitric oxide (NO), carbon monoxide (CO), oxygen (O(2)), hydrogen sulfide (H(2)S) are gaseous molecules that play important roles in the physiology and pathophysiology of eukaryotes. Tissue concentrations of these physiologically relevant gases vary remarkable from nM range for NO to high μM range of O(2). Various hemoproteins play a significant role in sensing and transducing cellular signals encoded by gaseous molecules or in transporting them. Soluble guanylyl cyclase (sGC) is a hemoprotein that plays vital roles in a wide range of physiological functions and combines the functions of gaseous sensor and signal transducer. sGC uniquely evolved to sense low non-toxic levels of NO and respond to elevated NO levels by increasing its catalytic ability to generate the secondary signaling messenger cyclic guanosine monophosphate (cGMP). This review discusses sGC’s gaseous ligand selectivity and the molecular basis for sGC function as high-affinity and selectivity NO receptor. The effects of other gaseous molecules and small molecules of cellular origin on sGC’s function are also discussed. Frontiers Media S.A. 2022-10-11 /pmc/articles/PMC9592903/ /pubmed/36304925 http://dx.doi.org/10.3389/fmolb.2022.1007768 Text en Copyright © 2022 Wu, Sharina and Martin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Wu, Gang
Sharina, Iraida
Martin, Emil
Soluble guanylyl cyclase: Molecular basis for ligand selectivity and action in vitro and in vivo
title Soluble guanylyl cyclase: Molecular basis for ligand selectivity and action in vitro and in vivo
title_full Soluble guanylyl cyclase: Molecular basis for ligand selectivity and action in vitro and in vivo
title_fullStr Soluble guanylyl cyclase: Molecular basis for ligand selectivity and action in vitro and in vivo
title_full_unstemmed Soluble guanylyl cyclase: Molecular basis for ligand selectivity and action in vitro and in vivo
title_short Soluble guanylyl cyclase: Molecular basis for ligand selectivity and action in vitro and in vivo
title_sort soluble guanylyl cyclase: molecular basis for ligand selectivity and action in vitro and in vivo
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592903/
https://www.ncbi.nlm.nih.gov/pubmed/36304925
http://dx.doi.org/10.3389/fmolb.2022.1007768
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