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A review of herb-induced liver injury in mainland china

Traditional medicines have greatly contributed to people’s health worldwide. However, in recent years, the frequent occurrence of herb-induced liver injury (HILI) has raised public concerns regarding the safety of herbs. HILI not only severely impacts public health, thus increasing its medical burde...

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Autores principales: Yang, Yan, Ge, Fei-Lin, Tang, Jin-Fa, Qin, Shuang-Lin, Zeng, Rui, Yao, Meng-Lin, Xiao, Xiao-He, Bai, Zhao-Fang, Tang, Cheng-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592926/
https://www.ncbi.nlm.nih.gov/pubmed/36304164
http://dx.doi.org/10.3389/fphar.2022.813073
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author Yang, Yan
Ge, Fei-Lin
Tang, Jin-Fa
Qin, Shuang-Lin
Zeng, Rui
Yao, Meng-Lin
Xiao, Xiao-He
Bai, Zhao-Fang
Tang, Cheng-Lin
author_facet Yang, Yan
Ge, Fei-Lin
Tang, Jin-Fa
Qin, Shuang-Lin
Zeng, Rui
Yao, Meng-Lin
Xiao, Xiao-He
Bai, Zhao-Fang
Tang, Cheng-Lin
author_sort Yang, Yan
collection PubMed
description Traditional medicines have greatly contributed to people’s health worldwide. However, in recent years, the frequent occurrence of herb-induced liver injury (HILI) has raised public concerns regarding the safety of herbs. HILI not only severely impacts public health, thus increasing its medical burden, but also consumes medical resources. However, the pharmacoepidemiology and risk factors of HILI are still unclear due to the complexity of herbs (medication theory, drug composition, dual properties of drugs and food, etc.). China is the country with the most extensive use of herbs and cases of HILI worldwide. The safety profile of herbs (especially with respect to HILI) has also affected the use of herbs internationally. Therefore, this review focuses on the epidemic situation of HILI in mainland China to compile its characteristics, while focusing on the three main aspects of patients, drugs, and unreasonable prescriptions to explore the potential risk factors. Our objective was to provide a reference for HILI pharmacovigilance and risk prevention and control and contribute to Chinese knowledge of the realisation of the “Medication without Harm” global safe medication strategic goal of the World Health Organization.
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spelling pubmed-95929262022-10-26 A review of herb-induced liver injury in mainland china Yang, Yan Ge, Fei-Lin Tang, Jin-Fa Qin, Shuang-Lin Zeng, Rui Yao, Meng-Lin Xiao, Xiao-He Bai, Zhao-Fang Tang, Cheng-Lin Front Pharmacol Pharmacology Traditional medicines have greatly contributed to people’s health worldwide. However, in recent years, the frequent occurrence of herb-induced liver injury (HILI) has raised public concerns regarding the safety of herbs. HILI not only severely impacts public health, thus increasing its medical burden, but also consumes medical resources. However, the pharmacoepidemiology and risk factors of HILI are still unclear due to the complexity of herbs (medication theory, drug composition, dual properties of drugs and food, etc.). China is the country with the most extensive use of herbs and cases of HILI worldwide. The safety profile of herbs (especially with respect to HILI) has also affected the use of herbs internationally. Therefore, this review focuses on the epidemic situation of HILI in mainland China to compile its characteristics, while focusing on the three main aspects of patients, drugs, and unreasonable prescriptions to explore the potential risk factors. Our objective was to provide a reference for HILI pharmacovigilance and risk prevention and control and contribute to Chinese knowledge of the realisation of the “Medication without Harm” global safe medication strategic goal of the World Health Organization. Frontiers Media S.A. 2022-10-11 /pmc/articles/PMC9592926/ /pubmed/36304164 http://dx.doi.org/10.3389/fphar.2022.813073 Text en Copyright © 2022 Yang, Ge, Tang, Qin, Zeng, Yao, Xiao, Bai and Tang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Yang, Yan
Ge, Fei-Lin
Tang, Jin-Fa
Qin, Shuang-Lin
Zeng, Rui
Yao, Meng-Lin
Xiao, Xiao-He
Bai, Zhao-Fang
Tang, Cheng-Lin
A review of herb-induced liver injury in mainland china
title A review of herb-induced liver injury in mainland china
title_full A review of herb-induced liver injury in mainland china
title_fullStr A review of herb-induced liver injury in mainland china
title_full_unstemmed A review of herb-induced liver injury in mainland china
title_short A review of herb-induced liver injury in mainland china
title_sort review of herb-induced liver injury in mainland china
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592926/
https://www.ncbi.nlm.nih.gov/pubmed/36304164
http://dx.doi.org/10.3389/fphar.2022.813073
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