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Maternal and Neonatal Outcomes in Pregnant Women With Coronavirus Disease 2019 in Korea

BACKGROUND: This study aimed to describe the maternal, obstetrical, and neonatal outcomes in pregnant women with coronavirus disease 2019 (COVID-19) and identify the predictors associated with the severity of COVID-19. METHODS: This multicenter observational study included consecutive pregnant women...

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Autores principales: Chung, Youseung, Kim, Eun Jin, Kim, Hee-Sung, Park, Kyung-Hwa, Baek, Ji Hyeon, Kim, Jungok, Lee, Ji Yeon, Lee, Chang-Seop, Lim, Seungjin, Kim, Shin-Woo, Kim, Eu Suk, Shi, Hye Jin, Hong, Shin Hee, Jun, Jae-Bum, Hong, Kyung-Wook, Choi, Jae-Phil, Kim, Jinyeong, Yang, Kyung Sook, Yoon, Young Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592939/
https://www.ncbi.nlm.nih.gov/pubmed/36281486
http://dx.doi.org/10.3346/jkms.2022.37.e297
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author Chung, Youseung
Kim, Eun Jin
Kim, Hee-Sung
Park, Kyung-Hwa
Baek, Ji Hyeon
Kim, Jungok
Lee, Ji Yeon
Lee, Chang-Seop
Lim, Seungjin
Kim, Shin-Woo
Kim, Eu Suk
Shi, Hye Jin
Hong, Shin Hee
Jun, Jae-Bum
Hong, Kyung-Wook
Choi, Jae-Phil
Kim, Jinyeong
Yang, Kyung Sook
Yoon, Young Kyung
author_facet Chung, Youseung
Kim, Eun Jin
Kim, Hee-Sung
Park, Kyung-Hwa
Baek, Ji Hyeon
Kim, Jungok
Lee, Ji Yeon
Lee, Chang-Seop
Lim, Seungjin
Kim, Shin-Woo
Kim, Eu Suk
Shi, Hye Jin
Hong, Shin Hee
Jun, Jae-Bum
Hong, Kyung-Wook
Choi, Jae-Phil
Kim, Jinyeong
Yang, Kyung Sook
Yoon, Young Kyung
author_sort Chung, Youseung
collection PubMed
description BACKGROUND: This study aimed to describe the maternal, obstetrical, and neonatal outcomes in pregnant women with coronavirus disease 2019 (COVID-19) and identify the predictors associated with the severity of COVID-19. METHODS: This multicenter observational study included consecutive pregnant women admitted because of COVID-19 confirmed using reverse transcriptase-polymerase chain reaction (RT-PCR) test at 15 hospitals in the Republic of Korea between January 2020 and December 2021. RESULTS: A total of 257 women with COVID-19 and 62 newborns were included in this study. Most of the patients developed this disease during the third trimester. Nine patients (7.4%) developed pregnancy-related complications. All pregnant women received inpatient treatment, of whom 9 (3.5%) required intensive care, but none of them died. The gestational age at COVID-19 diagnosis (odds ratio [OR], 1.096, 95% confidence interval [CI], 1.04–1.15) and parity (OR, 1.703, 95% CI, 1.13–2.57) were identified as significant risk factors of severe diseases. Among women who delivered, 78.5% underwent cesarean section. Preterm birth (38.5%), premature rupture of membranes (7.7%), and miscarriage (4.6%) occurred, but there was no stillbirth or neonatal death. The RT-PCR test of newborns’ amniotic fluid and umbilical cord blood samples was negative for severe acute respiratory syndrome coronavirus 2. CONCLUSION: At the time of COVID-19 diagnosis, gestational age and parity of pregnant women were the risk factors of disease severity. Vertical transmission of COVID-19 was not observed, and maternal severity did not significantly affect the neonatal prognosis.
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spelling pubmed-95929392022-10-31 Maternal and Neonatal Outcomes in Pregnant Women With Coronavirus Disease 2019 in Korea Chung, Youseung Kim, Eun Jin Kim, Hee-Sung Park, Kyung-Hwa Baek, Ji Hyeon Kim, Jungok Lee, Ji Yeon Lee, Chang-Seop Lim, Seungjin Kim, Shin-Woo Kim, Eu Suk Shi, Hye Jin Hong, Shin Hee Jun, Jae-Bum Hong, Kyung-Wook Choi, Jae-Phil Kim, Jinyeong Yang, Kyung Sook Yoon, Young Kyung J Korean Med Sci Original Article BACKGROUND: This study aimed to describe the maternal, obstetrical, and neonatal outcomes in pregnant women with coronavirus disease 2019 (COVID-19) and identify the predictors associated with the severity of COVID-19. METHODS: This multicenter observational study included consecutive pregnant women admitted because of COVID-19 confirmed using reverse transcriptase-polymerase chain reaction (RT-PCR) test at 15 hospitals in the Republic of Korea between January 2020 and December 2021. RESULTS: A total of 257 women with COVID-19 and 62 newborns were included in this study. Most of the patients developed this disease during the third trimester. Nine patients (7.4%) developed pregnancy-related complications. All pregnant women received inpatient treatment, of whom 9 (3.5%) required intensive care, but none of them died. The gestational age at COVID-19 diagnosis (odds ratio [OR], 1.096, 95% confidence interval [CI], 1.04–1.15) and parity (OR, 1.703, 95% CI, 1.13–2.57) were identified as significant risk factors of severe diseases. Among women who delivered, 78.5% underwent cesarean section. Preterm birth (38.5%), premature rupture of membranes (7.7%), and miscarriage (4.6%) occurred, but there was no stillbirth or neonatal death. The RT-PCR test of newborns’ amniotic fluid and umbilical cord blood samples was negative for severe acute respiratory syndrome coronavirus 2. CONCLUSION: At the time of COVID-19 diagnosis, gestational age and parity of pregnant women were the risk factors of disease severity. Vertical transmission of COVID-19 was not observed, and maternal severity did not significantly affect the neonatal prognosis. The Korean Academy of Medical Sciences 2022-09-26 /pmc/articles/PMC9592939/ /pubmed/36281486 http://dx.doi.org/10.3346/jkms.2022.37.e297 Text en © 2022 The Korean Academy of Medical Sciences. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Chung, Youseung
Kim, Eun Jin
Kim, Hee-Sung
Park, Kyung-Hwa
Baek, Ji Hyeon
Kim, Jungok
Lee, Ji Yeon
Lee, Chang-Seop
Lim, Seungjin
Kim, Shin-Woo
Kim, Eu Suk
Shi, Hye Jin
Hong, Shin Hee
Jun, Jae-Bum
Hong, Kyung-Wook
Choi, Jae-Phil
Kim, Jinyeong
Yang, Kyung Sook
Yoon, Young Kyung
Maternal and Neonatal Outcomes in Pregnant Women With Coronavirus Disease 2019 in Korea
title Maternal and Neonatal Outcomes in Pregnant Women With Coronavirus Disease 2019 in Korea
title_full Maternal and Neonatal Outcomes in Pregnant Women With Coronavirus Disease 2019 in Korea
title_fullStr Maternal and Neonatal Outcomes in Pregnant Women With Coronavirus Disease 2019 in Korea
title_full_unstemmed Maternal and Neonatal Outcomes in Pregnant Women With Coronavirus Disease 2019 in Korea
title_short Maternal and Neonatal Outcomes in Pregnant Women With Coronavirus Disease 2019 in Korea
title_sort maternal and neonatal outcomes in pregnant women with coronavirus disease 2019 in korea
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592939/
https://www.ncbi.nlm.nih.gov/pubmed/36281486
http://dx.doi.org/10.3346/jkms.2022.37.e297
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