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Maternal and Neonatal Outcomes in Pregnant Women With Coronavirus Disease 2019 in Korea
BACKGROUND: This study aimed to describe the maternal, obstetrical, and neonatal outcomes in pregnant women with coronavirus disease 2019 (COVID-19) and identify the predictors associated with the severity of COVID-19. METHODS: This multicenter observational study included consecutive pregnant women...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Medical Sciences
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592939/ https://www.ncbi.nlm.nih.gov/pubmed/36281486 http://dx.doi.org/10.3346/jkms.2022.37.e297 |
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author | Chung, Youseung Kim, Eun Jin Kim, Hee-Sung Park, Kyung-Hwa Baek, Ji Hyeon Kim, Jungok Lee, Ji Yeon Lee, Chang-Seop Lim, Seungjin Kim, Shin-Woo Kim, Eu Suk Shi, Hye Jin Hong, Shin Hee Jun, Jae-Bum Hong, Kyung-Wook Choi, Jae-Phil Kim, Jinyeong Yang, Kyung Sook Yoon, Young Kyung |
author_facet | Chung, Youseung Kim, Eun Jin Kim, Hee-Sung Park, Kyung-Hwa Baek, Ji Hyeon Kim, Jungok Lee, Ji Yeon Lee, Chang-Seop Lim, Seungjin Kim, Shin-Woo Kim, Eu Suk Shi, Hye Jin Hong, Shin Hee Jun, Jae-Bum Hong, Kyung-Wook Choi, Jae-Phil Kim, Jinyeong Yang, Kyung Sook Yoon, Young Kyung |
author_sort | Chung, Youseung |
collection | PubMed |
description | BACKGROUND: This study aimed to describe the maternal, obstetrical, and neonatal outcomes in pregnant women with coronavirus disease 2019 (COVID-19) and identify the predictors associated with the severity of COVID-19. METHODS: This multicenter observational study included consecutive pregnant women admitted because of COVID-19 confirmed using reverse transcriptase-polymerase chain reaction (RT-PCR) test at 15 hospitals in the Republic of Korea between January 2020 and December 2021. RESULTS: A total of 257 women with COVID-19 and 62 newborns were included in this study. Most of the patients developed this disease during the third trimester. Nine patients (7.4%) developed pregnancy-related complications. All pregnant women received inpatient treatment, of whom 9 (3.5%) required intensive care, but none of them died. The gestational age at COVID-19 diagnosis (odds ratio [OR], 1.096, 95% confidence interval [CI], 1.04–1.15) and parity (OR, 1.703, 95% CI, 1.13–2.57) were identified as significant risk factors of severe diseases. Among women who delivered, 78.5% underwent cesarean section. Preterm birth (38.5%), premature rupture of membranes (7.7%), and miscarriage (4.6%) occurred, but there was no stillbirth or neonatal death. The RT-PCR test of newborns’ amniotic fluid and umbilical cord blood samples was negative for severe acute respiratory syndrome coronavirus 2. CONCLUSION: At the time of COVID-19 diagnosis, gestational age and parity of pregnant women were the risk factors of disease severity. Vertical transmission of COVID-19 was not observed, and maternal severity did not significantly affect the neonatal prognosis. |
format | Online Article Text |
id | pubmed-9592939 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-95929392022-10-31 Maternal and Neonatal Outcomes in Pregnant Women With Coronavirus Disease 2019 in Korea Chung, Youseung Kim, Eun Jin Kim, Hee-Sung Park, Kyung-Hwa Baek, Ji Hyeon Kim, Jungok Lee, Ji Yeon Lee, Chang-Seop Lim, Seungjin Kim, Shin-Woo Kim, Eu Suk Shi, Hye Jin Hong, Shin Hee Jun, Jae-Bum Hong, Kyung-Wook Choi, Jae-Phil Kim, Jinyeong Yang, Kyung Sook Yoon, Young Kyung J Korean Med Sci Original Article BACKGROUND: This study aimed to describe the maternal, obstetrical, and neonatal outcomes in pregnant women with coronavirus disease 2019 (COVID-19) and identify the predictors associated with the severity of COVID-19. METHODS: This multicenter observational study included consecutive pregnant women admitted because of COVID-19 confirmed using reverse transcriptase-polymerase chain reaction (RT-PCR) test at 15 hospitals in the Republic of Korea between January 2020 and December 2021. RESULTS: A total of 257 women with COVID-19 and 62 newborns were included in this study. Most of the patients developed this disease during the third trimester. Nine patients (7.4%) developed pregnancy-related complications. All pregnant women received inpatient treatment, of whom 9 (3.5%) required intensive care, but none of them died. The gestational age at COVID-19 diagnosis (odds ratio [OR], 1.096, 95% confidence interval [CI], 1.04–1.15) and parity (OR, 1.703, 95% CI, 1.13–2.57) were identified as significant risk factors of severe diseases. Among women who delivered, 78.5% underwent cesarean section. Preterm birth (38.5%), premature rupture of membranes (7.7%), and miscarriage (4.6%) occurred, but there was no stillbirth or neonatal death. The RT-PCR test of newborns’ amniotic fluid and umbilical cord blood samples was negative for severe acute respiratory syndrome coronavirus 2. CONCLUSION: At the time of COVID-19 diagnosis, gestational age and parity of pregnant women were the risk factors of disease severity. Vertical transmission of COVID-19 was not observed, and maternal severity did not significantly affect the neonatal prognosis. The Korean Academy of Medical Sciences 2022-09-26 /pmc/articles/PMC9592939/ /pubmed/36281486 http://dx.doi.org/10.3346/jkms.2022.37.e297 Text en © 2022 The Korean Academy of Medical Sciences. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Chung, Youseung Kim, Eun Jin Kim, Hee-Sung Park, Kyung-Hwa Baek, Ji Hyeon Kim, Jungok Lee, Ji Yeon Lee, Chang-Seop Lim, Seungjin Kim, Shin-Woo Kim, Eu Suk Shi, Hye Jin Hong, Shin Hee Jun, Jae-Bum Hong, Kyung-Wook Choi, Jae-Phil Kim, Jinyeong Yang, Kyung Sook Yoon, Young Kyung Maternal and Neonatal Outcomes in Pregnant Women With Coronavirus Disease 2019 in Korea |
title | Maternal and Neonatal Outcomes in Pregnant Women With Coronavirus Disease 2019 in Korea |
title_full | Maternal and Neonatal Outcomes in Pregnant Women With Coronavirus Disease 2019 in Korea |
title_fullStr | Maternal and Neonatal Outcomes in Pregnant Women With Coronavirus Disease 2019 in Korea |
title_full_unstemmed | Maternal and Neonatal Outcomes in Pregnant Women With Coronavirus Disease 2019 in Korea |
title_short | Maternal and Neonatal Outcomes in Pregnant Women With Coronavirus Disease 2019 in Korea |
title_sort | maternal and neonatal outcomes in pregnant women with coronavirus disease 2019 in korea |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592939/ https://www.ncbi.nlm.nih.gov/pubmed/36281486 http://dx.doi.org/10.3346/jkms.2022.37.e297 |
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