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Freeze-drying platforms design for batch fabrication of Haversian system mimicking scaffolds with enhanced osteogenesis
The Haversian system is one of the most important pathways to repair bone defects, and it is the basic guarantee for the repair of bone defects, which means that the formation of the Haversian system indicates repairing of the defects. The integration of structure and function for tissue engineering...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9593081/ https://www.ncbi.nlm.nih.gov/pubmed/36304903 http://dx.doi.org/10.3389/fbioe.2022.1013528 |
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author | Lin, Licheng Huang, Xiuhong Li, Zhentao Zhang, Guiyin Yu, Hongbo Wan, Yi Zhou, Changren Zhou, Lin |
author_facet | Lin, Licheng Huang, Xiuhong Li, Zhentao Zhang, Guiyin Yu, Hongbo Wan, Yi Zhou, Changren Zhou, Lin |
author_sort | Lin, Licheng |
collection | PubMed |
description | The Haversian system is one of the most important pathways to repair bone defects, and it is the basic guarantee for the repair of bone defects, which means that the formation of the Haversian system indicates repairing of the defects. The integration of structure and function for tissue engineering scaffolds is of great importance in mimicking native bone tissue. However, in contrast to the increasing demands, how to rapidly prepare various sizes of such Haversian system mimicking scaffolds in batch becomes a major challenge. In this study, we designed three types of platforms with different sizes in combination with the freeze-drying approach. Chitosan/type I collagen composite materials were used to study the structure, morphology, and performance of the production, and the effects of the controlled architecture on osteogenesis. Results showed that the physicochemical effects of the mass fabricated scaffolds of various sizes met the requirements of bone repair materials. In addition, the scaffolds had good cytocompatibility and excellent in vivo bone repair performance, which have potential clinical applications. |
format | Online Article Text |
id | pubmed-9593081 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95930812022-10-26 Freeze-drying platforms design for batch fabrication of Haversian system mimicking scaffolds with enhanced osteogenesis Lin, Licheng Huang, Xiuhong Li, Zhentao Zhang, Guiyin Yu, Hongbo Wan, Yi Zhou, Changren Zhou, Lin Front Bioeng Biotechnol Bioengineering and Biotechnology The Haversian system is one of the most important pathways to repair bone defects, and it is the basic guarantee for the repair of bone defects, which means that the formation of the Haversian system indicates repairing of the defects. The integration of structure and function for tissue engineering scaffolds is of great importance in mimicking native bone tissue. However, in contrast to the increasing demands, how to rapidly prepare various sizes of such Haversian system mimicking scaffolds in batch becomes a major challenge. In this study, we designed three types of platforms with different sizes in combination with the freeze-drying approach. Chitosan/type I collagen composite materials were used to study the structure, morphology, and performance of the production, and the effects of the controlled architecture on osteogenesis. Results showed that the physicochemical effects of the mass fabricated scaffolds of various sizes met the requirements of bone repair materials. In addition, the scaffolds had good cytocompatibility and excellent in vivo bone repair performance, which have potential clinical applications. Frontiers Media S.A. 2022-10-11 /pmc/articles/PMC9593081/ /pubmed/36304903 http://dx.doi.org/10.3389/fbioe.2022.1013528 Text en Copyright © 2022 Lin, Huang, Li, Zhang, Yu, Wan, Zhou and Zhou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Lin, Licheng Huang, Xiuhong Li, Zhentao Zhang, Guiyin Yu, Hongbo Wan, Yi Zhou, Changren Zhou, Lin Freeze-drying platforms design for batch fabrication of Haversian system mimicking scaffolds with enhanced osteogenesis |
title | Freeze-drying platforms design for batch fabrication of Haversian system mimicking scaffolds with enhanced osteogenesis |
title_full | Freeze-drying platforms design for batch fabrication of Haversian system mimicking scaffolds with enhanced osteogenesis |
title_fullStr | Freeze-drying platforms design for batch fabrication of Haversian system mimicking scaffolds with enhanced osteogenesis |
title_full_unstemmed | Freeze-drying platforms design for batch fabrication of Haversian system mimicking scaffolds with enhanced osteogenesis |
title_short | Freeze-drying platforms design for batch fabrication of Haversian system mimicking scaffolds with enhanced osteogenesis |
title_sort | freeze-drying platforms design for batch fabrication of haversian system mimicking scaffolds with enhanced osteogenesis |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9593081/ https://www.ncbi.nlm.nih.gov/pubmed/36304903 http://dx.doi.org/10.3389/fbioe.2022.1013528 |
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