Status Cataplecticus with Rapid Eye Movement Sleep Excess in Late-onset Narcolepsy Type 1

A 57-year-old man presented with difficulty speaking and walking along with increased daytime somnolence. His symptoms fluctuated throughout the day but never completely disappeared. A neurological examination revealed mild dysarthria, limb weakness, and staggering gait. Polysomnography showed rapid...

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Autores principales: Ando, Takashi, Wakai, Masakazu, Kanbayashi, Takashi, Katsuno, Masahisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9593136/
https://www.ncbi.nlm.nih.gov/pubmed/35283376
http://dx.doi.org/10.2169/internalmedicine.8465-21
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author Ando, Takashi
Wakai, Masakazu
Kanbayashi, Takashi
Katsuno, Masahisa
author_facet Ando, Takashi
Wakai, Masakazu
Kanbayashi, Takashi
Katsuno, Masahisa
author_sort Ando, Takashi
collection PubMed
description A 57-year-old man presented with difficulty speaking and walking along with increased daytime somnolence. His symptoms fluctuated throughout the day but never completely disappeared. A neurological examination revealed mild dysarthria, limb weakness, and staggering gait. Polysomnography showed rapid eye movement (REM) sleep excess (55.0%). Multiple sleep latency tests revealed a mean sleep latency of zero minutes with sleep-onset REM periods in all naps. The Orexin-A concentration in the cerebrospinal fluid was low (50.8 pg/mL). Human leukocyte antigen testing demonstrated DQB1*0602 positivity. His neurological symptoms were relieved by clomipramine. Thus, he was diagnosed with late-onset narcolepsy type 1 with status cataplecticus.
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spelling pubmed-95931362022-11-07 Status Cataplecticus with Rapid Eye Movement Sleep Excess in Late-onset Narcolepsy Type 1 Ando, Takashi Wakai, Masakazu Kanbayashi, Takashi Katsuno, Masahisa Intern Med Case Report A 57-year-old man presented with difficulty speaking and walking along with increased daytime somnolence. His symptoms fluctuated throughout the day but never completely disappeared. A neurological examination revealed mild dysarthria, limb weakness, and staggering gait. Polysomnography showed rapid eye movement (REM) sleep excess (55.0%). Multiple sleep latency tests revealed a mean sleep latency of zero minutes with sleep-onset REM periods in all naps. The Orexin-A concentration in the cerebrospinal fluid was low (50.8 pg/mL). Human leukocyte antigen testing demonstrated DQB1*0602 positivity. His neurological symptoms were relieved by clomipramine. Thus, he was diagnosed with late-onset narcolepsy type 1 with status cataplecticus. The Japanese Society of Internal Medicine 2022-03-12 2022-10-01 /pmc/articles/PMC9593136/ /pubmed/35283376 http://dx.doi.org/10.2169/internalmedicine.8465-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Ando, Takashi
Wakai, Masakazu
Kanbayashi, Takashi
Katsuno, Masahisa
Status Cataplecticus with Rapid Eye Movement Sleep Excess in Late-onset Narcolepsy Type 1
title Status Cataplecticus with Rapid Eye Movement Sleep Excess in Late-onset Narcolepsy Type 1
title_full Status Cataplecticus with Rapid Eye Movement Sleep Excess in Late-onset Narcolepsy Type 1
title_fullStr Status Cataplecticus with Rapid Eye Movement Sleep Excess in Late-onset Narcolepsy Type 1
title_full_unstemmed Status Cataplecticus with Rapid Eye Movement Sleep Excess in Late-onset Narcolepsy Type 1
title_short Status Cataplecticus with Rapid Eye Movement Sleep Excess in Late-onset Narcolepsy Type 1
title_sort status cataplecticus with rapid eye movement sleep excess in late-onset narcolepsy type 1
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9593136/
https://www.ncbi.nlm.nih.gov/pubmed/35283376
http://dx.doi.org/10.2169/internalmedicine.8465-21
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