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Repeated Brain Magnetic Resonance Imaging Provides Clues for the Diagnosis of Autoimmune Glial Fibrillary Acid Protein Astrocytopathy

We herein report a 47-year-old man with autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A) revealed by periventricular radial linear enhancement on repeated brain magnetic resonance imaging (MRI). He presented with a history of headache and a fever followed by somnolence and worsenin...

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Autores principales: Natori, Takahiro, Fukao, Toko, Watanabe, Tsubasa, Kurita, Takafumi, Hata, Takanori, Kimura, Akio, Shindo, Kazumasa, Shimohata, Takayoshi, Takiyama, Yoshihisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9593140/
https://www.ncbi.nlm.nih.gov/pubmed/35228425
http://dx.doi.org/10.2169/internalmedicine.8964-21
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author Natori, Takahiro
Fukao, Toko
Watanabe, Tsubasa
Kurita, Takafumi
Hata, Takanori
Kimura, Akio
Shindo, Kazumasa
Shimohata, Takayoshi
Takiyama, Yoshihisa
author_facet Natori, Takahiro
Fukao, Toko
Watanabe, Tsubasa
Kurita, Takafumi
Hata, Takanori
Kimura, Akio
Shindo, Kazumasa
Shimohata, Takayoshi
Takiyama, Yoshihisa
author_sort Natori, Takahiro
collection PubMed
description We herein report a 47-year-old man with autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A) revealed by periventricular radial linear enhancement on repeated brain magnetic resonance imaging (MRI). He presented with a history of headache and a fever followed by somnolence and worsening of consciousness. On admission (16 days from the onset), although lymphocytic pleocytosis and hypoglycorrhachia in the cerebrospinal fluid (CSF) were noted, initial brain MRI demonstrated non-specific findings. At 30 days from the onset, repeated brain MRI revealed characteristic findings of GFAP-A, and we detected anti-GFAP antibodies in the CSF. Thus, repeated brain MRI provides clues for the diagnosis of GFAP-A.
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spelling pubmed-95931402022-11-07 Repeated Brain Magnetic Resonance Imaging Provides Clues for the Diagnosis of Autoimmune Glial Fibrillary Acid Protein Astrocytopathy Natori, Takahiro Fukao, Toko Watanabe, Tsubasa Kurita, Takafumi Hata, Takanori Kimura, Akio Shindo, Kazumasa Shimohata, Takayoshi Takiyama, Yoshihisa Intern Med Case Report We herein report a 47-year-old man with autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A) revealed by periventricular radial linear enhancement on repeated brain magnetic resonance imaging (MRI). He presented with a history of headache and a fever followed by somnolence and worsening of consciousness. On admission (16 days from the onset), although lymphocytic pleocytosis and hypoglycorrhachia in the cerebrospinal fluid (CSF) were noted, initial brain MRI demonstrated non-specific findings. At 30 days from the onset, repeated brain MRI revealed characteristic findings of GFAP-A, and we detected anti-GFAP antibodies in the CSF. Thus, repeated brain MRI provides clues for the diagnosis of GFAP-A. The Japanese Society of Internal Medicine 2022-02-26 2022-10-01 /pmc/articles/PMC9593140/ /pubmed/35228425 http://dx.doi.org/10.2169/internalmedicine.8964-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Natori, Takahiro
Fukao, Toko
Watanabe, Tsubasa
Kurita, Takafumi
Hata, Takanori
Kimura, Akio
Shindo, Kazumasa
Shimohata, Takayoshi
Takiyama, Yoshihisa
Repeated Brain Magnetic Resonance Imaging Provides Clues for the Diagnosis of Autoimmune Glial Fibrillary Acid Protein Astrocytopathy
title Repeated Brain Magnetic Resonance Imaging Provides Clues for the Diagnosis of Autoimmune Glial Fibrillary Acid Protein Astrocytopathy
title_full Repeated Brain Magnetic Resonance Imaging Provides Clues for the Diagnosis of Autoimmune Glial Fibrillary Acid Protein Astrocytopathy
title_fullStr Repeated Brain Magnetic Resonance Imaging Provides Clues for the Diagnosis of Autoimmune Glial Fibrillary Acid Protein Astrocytopathy
title_full_unstemmed Repeated Brain Magnetic Resonance Imaging Provides Clues for the Diagnosis of Autoimmune Glial Fibrillary Acid Protein Astrocytopathy
title_short Repeated Brain Magnetic Resonance Imaging Provides Clues for the Diagnosis of Autoimmune Glial Fibrillary Acid Protein Astrocytopathy
title_sort repeated brain magnetic resonance imaging provides clues for the diagnosis of autoimmune glial fibrillary acid protein astrocytopathy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9593140/
https://www.ncbi.nlm.nih.gov/pubmed/35228425
http://dx.doi.org/10.2169/internalmedicine.8964-21
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